BR9407300A - Composto cristalino de sal de ácido benzóico de 4'-deóxi-4'-epi-metilamino avermectina B1A/B1B hemiidratado processo para a sua preparação e para o controle de insetos agrícolas e composição útil para o tratamento de infestações de plantas ou de produtos de plantas - Google Patents

Composto cristalino de sal de ácido benzóico de 4'-deóxi-4'-epi-metilamino avermectina B1A/B1B hemiidratado processo para a sua preparação e para o controle de insetos agrícolas e composição útil para o tratamento de infestações de plantas ou de produtos de plantas

Info

Publication number: BR9407300A
Authority: BR; Brazil
Prior art keywords: hemihydrate; epi; deoxy; benzoic acid; acid salt
Prior art date: 1993-08-19

Application number

BR9407300A

Other languages

English (en)

Inventor

Raymond Cvetocivh

Richard Demchak

James A Mccauley

Richard J Varsolona

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-19

Filing date

1994-08-15

Publication date

1996-10-08

1994-08-15 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1996-10-08 Publication of BR9407300A publication Critical patent/BR9407300A/pt

Links

ZFUKERYTFURFGA-UHFFFAOYSA-N Avermectin B1b Natural products O1C(C)C(O)C(OC)CC1OC1C(OC)CC(OC2C(=CCC3CC(CC4(O3)C=CC(C)C(C(C)C)O4)OC(=O)C3C=C(C)C(O)C4OCC(C34O)=CC=CC2C)C)OC1C ZFUKERYTFURFGA-UHFFFAOYSA-N 0.000 title abstract 2
RRZXIRBKKLTSOM-UHFFFAOYSA-N avermectin B1a Natural products C1=CC(C)C(C(C)CC)OC11OC(CC=C(C)C(OC2OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C2)C(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 RRZXIRBKKLTSOM-UHFFFAOYSA-N 0.000 title abstract 2
241000238631 Hexapoda Species 0.000 title 1
206010061217 Infestation Diseases 0.000 title 1
FQSQGNAYFVLZMP-UHFFFAOYSA-N benzoic acid;hydrate Chemical compound O.OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 FQSQGNAYFVLZMP-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
ZFUKERYTFURFGA-PVVXTEPVSA-N avermectin B1b Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C ZFUKERYTFURFGA-PVVXTEPVSA-N 0.000 abstract 1
150000001558 benzoic acid derivatives Chemical class 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Agronomy & Crop Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Environmental Sciences (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

BR9407300A 1993-08-19 1994-08-15 Composto cristalino de sal de ácido benzóico de 4'-deóxi-4'-epi-metilamino avermectina B1A/B1B hemiidratado processo para a sua preparação e para o controle de insetos agrícolas e composição útil para o tratamento de infestações de plantas ou de produtos de plantas BR9407300A (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10918993A	1993-08-19	1993-08-19

Publications (1)

Publication Number	Publication Date
BR9407300A true BR9407300A (pt)	1996-10-08

Family

ID=22326282

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9407300A BR9407300A (pt)	1993-08-19	1994-08-15	Composto cristalino de sal de ácido benzóico de 4'-deóxi-4'-epi-metilamino avermectina B1A/B1B hemiidratado processo para a sua preparação e para o controle de insetos agrícolas e composição útil para o tratamento de infestações de plantas ou de produtos de plantas

Country Status (25)

Country	Link
EP (1)	EP0714400B1 (pt)
JP (3)	JP3954093B2 (pt)
KR (1)	KR100370697B1 (pt)
CN (1)	CN1041523C (pt)
AT (1)	ATE187735T1 (pt)
AU (1)	AU684828B2 (pt)
BR (1)	BR9407300A (pt)
CA (1)	CA2168843C (pt)
CY (1)	CY2181B1 (pt)
CZ (1)	CZ287929B6 (pt)
DE (1)	DE69422182T2 (pt)
DK (1)	DK0714400T3 (pt)
ES (1)	ES2139753T3 (pt)
FI (2)	FI110783B (pt)
GR (1)	GR3032164T3 (pt)
HU (1)	HU217769B (pt)
LV (1)	LV12571B (pt)
NO (1)	NO305658B1 (pt)
NZ (1)	NZ273129A (pt)
PL (1)	PL176300B1 (pt)
PT (1)	PT714400E (pt)
RU (1)	RU2133753C1 (pt)
SK (1)	SK281684B6 (pt)
WO (1)	WO1995005390A1 (pt)
ZA (1)	ZA946203B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6486195B1 (en) *	1993-08-19	2002-11-26	Merck & Co., Inc.	Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
CR6574A (es)	2001-02-27	2004-10-28	Syngenta Participations Ag	Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
CN102884050B (zh) *	2010-02-23	2014-05-28	日本化药株式会社	2-乙基-3,7-二甲基-6-(4-(三氟甲氧基)苯氧基)喹啉-4-基甲基碳酸酯的稳定晶体、其制备方法以及包含该晶体的农用化学组合物
CN106995476B (zh) *	2017-05-16	2018-03-13	河北美荷药业有限公司	一种甲氨基阿维菌素b2苯甲酸盐的制备方法
CN108840893A (zh) *	2018-07-01	2018-11-20	李万强	一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法
CN109912671B (zh) *	2019-04-12	2022-04-26	宁夏泰益欣生物科技有限公司	一种利用阿维菌素结晶母液提取阿维菌素B2a的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57212200A (en) *	1981-06-23	1982-12-27	Takeda Chem Ind Ltd	Preparation of echinoside a
GB8518422D0 (en) *	1985-07-22	1985-08-29	Beecham Group Plc	Compounds
IT1216059B (it) *	1988-03-11	1990-02-22	Crc Ricerca Chim	Procedimento per la separazione di diastereomeri macrociclici.
JPH0631302B2 (ja) *	1988-11-16	1994-04-27	日本化薬株式会社	エトポシド−２−ジメチルアミノ体塩酸二水和結晶及びその製造法
JPH0615557B2 (ja) *	1990-02-19	1994-03-02	ヤマサ醤油株式会社	２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
JPH0446192A (ja) *	1990-06-12	1992-02-17	Nippon Kayaku Co Ltd	オキセタノシンｇ無水物結晶及びその製造法
IL98599A (en) *	1990-06-28	1995-06-29	Merck & Co Inc	Stable salts of 4"-deoxy-4"-epi-methylamino avermectin b1a/b1b and insecticidal compositions containing them
JP2652272B2 (ja) *	1990-12-31	1997-09-10	住化ファインケム株式会社	１−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法
ATE168114T1 (de) *	1991-05-15	1998-07-15	Yamanouchi Pharma Co Ltd	(-)-(s)-2,8-dimethyl-3-methylen-1-oxa-8- azaspiro(4,5)decan l-tartrat
JP2848721B2 (ja) *	1991-08-09	1999-01-20	森永乳業株式会社	結晶ラクチュロース三水和物とその製造法

1994
- 1994-08-15 NZ NZ273129A patent/NZ273129A/en not_active IP Right Cessation
- 1994-08-15 JP JP50713095A patent/JP3954093B2/ja not_active Expired - Lifetime
- 1994-08-15 PL PL94313043A patent/PL176300B1/pl unknown
- 1994-08-15 DK DK94926502T patent/DK0714400T3/da active
- 1994-08-15 AT AT94926502T patent/ATE187735T1/de active
- 1994-08-15 ES ES94926502T patent/ES2139753T3/es not_active Expired - Lifetime
- 1994-08-15 BR BR9407300A patent/BR9407300A/pt not_active IP Right Cessation
- 1994-08-15 CN CN94193136A patent/CN1041523C/zh not_active Expired - Lifetime
- 1994-08-15 PT PT94926502T patent/PT714400E/pt unknown
- 1994-08-15 SK SK209-96A patent/SK281684B6/sk not_active IP Right Cessation
- 1994-08-15 DE DE69422182T patent/DE69422182T2/de not_active Expired - Lifetime
- 1994-08-15 HU HU9600345A patent/HU217769B/hu unknown
- 1994-08-15 RU RU96107041A patent/RU2133753C1/ru active
- 1994-08-15 EP EP94926502A patent/EP0714400B1/en not_active Expired - Lifetime
- 1994-08-15 KR KR1019960700754A patent/KR100370697B1/ko not_active Expired - Lifetime
- 1994-08-15 WO PCT/US1994/009207 patent/WO1995005390A1/en active IP Right Grant
- 1994-08-15 CA CA002168843A patent/CA2168843C/en not_active Expired - Lifetime
- 1994-08-15 CZ CZ1996459A patent/CZ287929B6/cs not_active IP Right Cessation
- 1994-08-15 AU AU76319/94A patent/AU684828B2/en not_active Expired
- 1994-08-17 ZA ZA946203A patent/ZA946203B/xx unknown
1996
- 1996-02-16 FI FI960725A patent/FI110783B/fi not_active IP Right Cessation
- 1996-02-16 NO NO960618A patent/NO305658B1/no not_active IP Right Cessation
1999
- 1999-12-16 GR GR990403202T patent/GR3032164T3/el unknown
2000
- 2000-08-10 CY CY0000041A patent/CY2181B1/xx unknown
- 2000-09-07 LV LVP-00-120A patent/LV12571B/en unknown
2002
- 2002-06-11 FI FI20021120A patent/FI111165B/fi not_active IP Right Cessation
2007
- 2007-02-09 JP JP2007030096A patent/JP2007176946A/ja not_active Withdrawn
2011
- 2011-05-25 JP JP2011117141A patent/JP2011207899A/ja active Pending

Also Published As

Publication number	Publication date
CA2168843A1 (en)	1995-02-23
EP0714400B1 (en)	1999-12-15
ES2139753T3 (es)	2000-02-16
SK20996A3 (en)	1996-06-05
JP2007176946A (ja)	2007-07-12
FI20021120L (fi)	2002-06-11
KR960703936A (ko)	1996-08-31
JPH09502169A (ja)	1997-03-04
JP3954093B2 (ja)	2007-08-08
HU9600345D0 (en)	1996-04-29
CN1041523C (zh)	1999-01-06
RU2133753C1 (ru)	1999-07-27
FI960725A0 (fi)	1996-02-16
PL313043A1 (en)	1996-05-27
KR100370697B1 (ko)	2003-06-11
AU7631994A (en)	1995-03-14
ATE187735T1 (de)	2000-01-15
NO305658B1 (no)	1999-07-05
DK0714400T3 (da)	2000-04-10
ZA946203B (en)	1995-03-31
CN1129453A (zh)	1996-08-21
FI110783B (fi)	2003-03-31
HU217769B (hu)	2000-04-28
NO960618L (no)	1996-02-16
NZ273129A (en)	1996-08-27
PT714400E (pt)	2000-05-31
FI960725L (fi)	1996-02-16
CZ45996A3 (en)	1996-05-15
CY2181B1 (en)	2002-08-23
DE69422182T2 (de)	2000-06-21
FI111165B (fi)	2003-06-13
SK281684B6 (sk)	2001-06-11
PL176300B1 (pl)	1999-05-31
LV12571B (en)	2001-04-20
CZ287929B6 (cs)	2001-03-14
DE69422182D1 (de)	2000-01-20
HUT73552A (en)	1996-08-28
JP2011207899A (ja)	2011-10-20
CA2168843C (en)	2004-10-19
LV12571A (en)	2000-11-20
WO1995005390A1 (en)	1995-02-23
NO960618D0 (no)	1996-02-16
EP0714400A1 (en)	1996-06-05
GR3032164T3 (en)	2000-04-27
AU684828B2 (en)	1998-01-08

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Legal Events

Date	Code	Title	Description
1999-06-08	FB36	Technical and formal requirements: requirement - article 36 of industrial property law
1999-10-13	FF	Decision: intention to grant
2000-05-02	FG9A	Patent or certificate of addition granted
2011-04-05	B25D	Requested change of name of applicant approved	Owner name: MERCK SHARP AND DOHME CORP. (US) Free format text: NOME ALTERADO DE: MERCK AND CO., INC.
2013-09-10	B25G	Requested change of headquarter approved	Owner name: SCHERING CORPORATION (US)
2013-09-24	B25L	Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled	Owner name: MERCK SHARP AND DOHME CORP. (US) Free format text: ANULADA A ALTERACAO DE SEDE PUBLICADA NA RPI NO 2227, DE 10/09/2013 POR TER SIDO INDEVIDA, UMA VEZ QUE O ATO REQUERIDO FOI DIVERSO.
2013-10-08	B25A	Requested transfer of rights approved	Owner name: SCHERING CORPORATION, (US)
2013-11-05	B25G	Requested change of headquarter approved	Owner name: SCHERING CORPORATION, (US) , MERCK SHARP AND DOHME
2015-07-07	B21A	Patent or certificate of addition expired [chapter 21.1 patent gazette]	Free format text: PATENTE EXTINTA EM 15/08/2014