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BR112019001141A2 - compostos diaza-heterobicíclicos substituídos e uso dos mesmos - Google Patents

compostos diaza-heterobicíclicos substituídos e uso dos mesmos

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Publication number
BR112019001141A2
BR112019001141A2 BR112019001141-2A BR112019001141A BR112019001141A2 BR 112019001141 A2 BR112019001141 A2 BR 112019001141A2 BR 112019001141 A BR112019001141 A BR 112019001141A BR 112019001141 A2 BR112019001141 A2 BR 112019001141A2
Authority
BR
Brazil
Prior art keywords
treatment
diazaheterobicyclic
substituted
compounds
prevention
Prior art date
Application number
BR112019001141-2A
Other languages
English (en)
Inventor
Delbeck Martina
Hahn Michael
Müller Thomas
Lustig Klemens
Anlahr Johanna
Albus Udo
Gehring Doris
ROSENSTEIN Björn
Collins Karl
Lindner Niels
Nicolai Janine
Beck-Broichsitter Moritz
Original Assignee
Bayer Aktiengesellschaft
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of BR112019001141A2 publication Critical patent/BR112019001141A2/pt

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • G16C20/64—Screening of libraries
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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Abstract

o presente pedido se refere a compostos diaza-heterobicíclicos (imidazo[1,2-a]piridin-3-il)metil-substituídos inovadores, a processos para a preparação dos mesmos, ao uso dos mesmos em separado ou em combinações para o tratamento e/ou prevenção de doenças, e ao uso dos mesmos para a produção de medicamentos para o tratamento e/ou prevenção de doenças, especialmente para o tratamento e/ou prevenção de transtornos respiratórios incluindo transtornos respiratórios relacionados ao sono tais como apneia obstrutiva do sono e apneia central do sono e ronco. o presente pedido se refere ainda a um método de constatação de um composto que tem propriedades de bloqueio de task-1- e/ou task-3.
BR112019001141-2A 2016-07-20 2017-07-10 compostos diaza-heterobicíclicos substituídos e uso dos mesmos BR112019001141A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16180315 2016-07-20
EP16180315.0 2016-07-20
EP16203964.8 2016-12-14
EP16203964 2016-12-14
PCT/EP2017/067273 WO2018015196A1 (de) 2016-07-20 2017-07-10 Substituierte diazaheterobicyclische verbindungen und ihre verwendung

Publications (1)

Publication Number Publication Date
BR112019001141A2 true BR112019001141A2 (pt) 2019-04-30

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ID=59381270

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Application Number Title Priority Date Filing Date
BR112019001141-2A BR112019001141A2 (pt) 2016-07-20 2017-07-10 compostos diaza-heterobicíclicos substituídos e uso dos mesmos

Country Status (21)

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US (2) US20210024545A1 (pt)
EP (1) EP3487856B1 (pt)
JP (3) JP6999639B2 (pt)
KR (1) KR102444687B1 (pt)
CN (2) CN113851196A (pt)
AU (2) AU2017298421B2 (pt)
BR (1) BR112019001141A2 (pt)
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