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BR112018016433A2 - inibidores de heteroarila de pad4 - Google Patents

inibidores de heteroarila de pad4

Info

Publication number
BR112018016433A2
BR112018016433A2 BR112018016433-0A BR112018016433A BR112018016433A2 BR 112018016433 A2 BR112018016433 A2 BR 112018016433A2 BR 112018016433 A BR112018016433 A BR 112018016433A BR 112018016433 A2 BR112018016433 A2 BR 112018016433A2
Authority
BR
Brazil
Prior art keywords
pad4
inhibitors
heteroaryl inhibitors
heteroaryl
compositions
Prior art date
Application number
BR112018016433-0A
Other languages
English (en)
Inventor
Devraj Rajesh
Kumaravel Gnanasambandam
Atton Holly
Beaumont Edward
Gadouleau Elise
Gleave Laura
Stephen Kerry Philip
Lecci Cristina
Meniconi Mirco
Monck Nat
Palfrey Jordan
Papadopoulos Kostas
Tye Heather
A. Woods Philip
Original Assignee
Padlock Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Padlock Therapeutics, Inc. filed Critical Padlock Therapeutics, Inc.
Publication of BR112018016433A2 publication Critical patent/BR112018016433A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Abstract

a presente invenção refere-se a compostos úteis como inibidores de pad4, composições dos mesmos, e métodos de tratamento de transtornos relacionados com pad4.
BR112018016433-0A 2016-02-23 2017-02-22 inibidores de heteroarila de pad4 BR112018016433A2 (pt)

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