BR112017018964A2 - uso de plinabulin e métodos para tratar tumor cerebral - Google Patents
uso de plinabulin e métodos para tratar tumor cerebralInfo
- Publication number
- BR112017018964A2 BR112017018964A2 BR112017018964A BR112017018964A BR112017018964A2 BR 112017018964 A2 BR112017018964 A2 BR 112017018964A2 BR 112017018964 A BR112017018964 A BR 112017018964A BR 112017018964 A BR112017018964 A BR 112017018964A BR 112017018964 A2 BR112017018964 A2 BR 112017018964A2
- Authority
- BR
- Brazil
- Prior art keywords
- plinabulin
- methods
- brain tumor
- treat brain
- treat
- Prior art date
Links
- UNRCMCRRFYFGFX-TYPNBTCFSA-N plinabulin Chemical compound N1C=NC(\C=C/2C(NC(=C\C=3C=CC=CC=3)/C(=O)N\2)=O)=C1C(C)(C)C UNRCMCRRFYFGFX-TYPNBTCFSA-N 0.000 title abstract 3
- 229950011498 plinabulin Drugs 0.000 title abstract 3
- 208000003174 Brain Neoplasms Diseases 0.000 title abstract 2
- 201000010915 Glioblastoma multiforme Diseases 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
são divulgados aqui métodos de tratamento de um tumor cerebral através da administração de plinabulin. algumas modalidades referem-se ao tratamento de glioblastoma multiforme através da administração de plinabulin.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562129623P | 2015-03-06 | 2015-03-06 | |
US201562249807P | 2015-11-02 | 2015-11-02 | |
PCT/US2016/020396 WO2016144636A1 (en) | 2015-03-06 | 2016-03-02 | Method of treating a brain tumor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017018964A2 true BR112017018964A2 (pt) | 2018-05-22 |
Family
ID=56880412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017018964A BR112017018964A2 (pt) | 2015-03-06 | 2016-03-02 | uso de plinabulin e métodos para tratar tumor cerebral |
Country Status (17)
Country | Link |
---|---|
US (2) | US10076518B2 (pt) |
EP (1) | EP3265091A4 (pt) |
JP (2) | JP6904570B2 (pt) |
KR (1) | KR102623404B1 (pt) |
CN (1) | CN107530340B (pt) |
AU (2) | AU2016229295B2 (pt) |
BR (1) | BR112017018964A2 (pt) |
CA (1) | CA2978679A1 (pt) |
CL (1) | CL2017002242A1 (pt) |
HK (2) | HK1249051A1 (pt) |
IL (1) | IL254262A0 (pt) |
MX (1) | MX385914B (pt) |
MY (1) | MY194341A (pt) |
RU (1) | RU2728796C2 (pt) |
SG (1) | SG11201707128TA (pt) |
WO (1) | WO2016144636A1 (pt) |
ZA (1) | ZA201706035B (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HK1250008A1 (zh) | 2015-03-06 | 2018-11-23 | 万春药业公司 | 治療與ras突變相關的癌症的方法 |
JP6904570B2 (ja) | 2015-03-06 | 2021-07-21 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | 脳腫瘍の治療方法 |
CA2991059C (en) | 2015-07-13 | 2024-01-16 | Beyondspring Pharmaceuticals, Inc. | Plinabulin monohydrate polymorphs |
BR112018016054A2 (pt) | 2016-02-08 | 2019-02-12 | Beyondspring Pharmaceuticals, Inc. | composições farmacêuticas e/ou métodos para tratar câncer e/ou para romper vasculatura de tumor associada ao câncer em indivíduo |
KR20190015361A (ko) | 2016-06-06 | 2019-02-13 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증을 줄이는 조성물 및 방법 |
EP3565812B1 (en) | 2017-01-06 | 2023-12-27 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
MY201811A (en) * | 2017-02-01 | 2024-03-19 | Beyondspring Pharmaceuticals Inc | Method of reducing neutropenia |
JP7350015B2 (ja) | 2018-01-24 | 2023-09-25 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | プリナブリンの投与による血小板減少症を軽減するための組成物および方法 |
JP2021530507A (ja) | 2018-07-18 | 2021-11-11 | マンザニータ ファーマシューティカルズ,インク. | 神経細胞に抗がん剤を送達するためのコンジュゲート、その使用方法及び製造方法 |
WO2021150109A1 (en) * | 2020-01-22 | 2021-07-29 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Abt-751 and ionizing radiation |
AU2021251277A1 (en) * | 2020-04-10 | 2022-11-10 | Lantern Pharma Inc. | Hydroxyureamethyl-acylfulvene for treating brain cancer or CNS cancer |
MX2023008106A (es) * | 2021-01-08 | 2023-09-21 | Lantern Pharma Inc | Tratamiento de metástasis cerebrales y metástasis del cns usando iludinas o hidroxilureametil acilfulveno. |
US20240197723A1 (en) * | 2021-04-09 | 2024-06-20 | Beyondspring Pharmaceuticals, Inc. | Therapeutic compositions and methods for treating tumors |
CN117860672A (zh) | 2022-10-11 | 2024-04-12 | 大连万春布林医药有限公司 | 一种普那布林胶束组合物及其制备方法 |
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JP6904570B2 (ja) | 2015-03-06 | 2021-07-21 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | 脳腫瘍の治療方法 |
HK1250008A1 (zh) | 2015-03-06 | 2018-11-23 | 万春药业公司 | 治療與ras突變相關的癌症的方法 |
CA2991059C (en) | 2015-07-13 | 2024-01-16 | Beyondspring Pharmaceuticals, Inc. | Plinabulin monohydrate polymorphs |
BR112018016054A2 (pt) | 2016-02-08 | 2019-02-12 | Beyondspring Pharmaceuticals, Inc. | composições farmacêuticas e/ou métodos para tratar câncer e/ou para romper vasculatura de tumor associada ao câncer em indivíduo |
KR20190015361A (ko) | 2016-06-06 | 2019-02-13 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증을 줄이는 조성물 및 방법 |
EP3565812B1 (en) | 2017-01-06 | 2023-12-27 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
MY201811A (en) | 2017-02-01 | 2024-03-19 | Beyondspring Pharmaceuticals Inc | Method of reducing neutropenia |
WO2018169887A1 (en) | 2017-03-13 | 2018-09-20 | Beyondspring Pharmaceuticals, Inc. | Compositions of plinabulin and use thereof |
-
2016
- 2016-03-02 JP JP2017546767A patent/JP6904570B2/ja active Active
- 2016-03-02 CN CN201680020652.9A patent/CN107530340B/zh active Active
- 2016-03-02 MX MX2017011375A patent/MX385914B/es unknown
- 2016-03-02 EP EP16762150.7A patent/EP3265091A4/en active Pending
- 2016-03-02 BR BR112017018964A patent/BR112017018964A2/pt not_active Application Discontinuation
- 2016-03-02 CA CA2978679A patent/CA2978679A1/en active Pending
- 2016-03-02 MY MYPI2017703256A patent/MY194341A/en unknown
- 2016-03-02 HK HK18108933.3A patent/HK1249051A1/zh unknown
- 2016-03-02 US US15/555,956 patent/US10076518B2/en active Active
- 2016-03-02 SG SG11201707128TA patent/SG11201707128TA/en unknown
- 2016-03-02 WO PCT/US2016/020396 patent/WO2016144636A1/en active Application Filing
- 2016-03-02 RU RU2017131448A patent/RU2728796C2/ru active
- 2016-03-02 HK HK18108504.2A patent/HK1250007A1/zh unknown
- 2016-03-02 KR KR1020177026283A patent/KR102623404B1/ko active Active
- 2016-03-02 AU AU2016229295A patent/AU2016229295B2/en active Active
-
2017
- 2017-08-31 IL IL254262A patent/IL254262A0/en unknown
- 2017-09-04 CL CL2017002242A patent/CL2017002242A1/es unknown
- 2017-09-05 ZA ZA2017/06035A patent/ZA201706035B/en unknown
-
2018
- 2018-09-05 US US16/122,482 patent/US10357491B2/en active Active
-
2021
- 2021-02-22 JP JP2021026411A patent/JP7264331B2/ja active Active
- 2021-10-19 AU AU2021254549A patent/AU2021254549B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
RU2017131448A3 (pt) | 2019-08-20 |
WO2016144636A1 (en) | 2016-09-15 |
MY194341A (en) | 2022-11-29 |
CN107530340B (zh) | 2021-06-08 |
KR102623404B1 (ko) | 2024-01-11 |
AU2021254549A1 (en) | 2021-11-18 |
MX2017011375A (es) | 2018-01-23 |
JP6904570B2 (ja) | 2021-07-21 |
AU2016229295B2 (en) | 2021-11-04 |
AU2021254549B2 (en) | 2024-10-24 |
HK1249051A1 (zh) | 2018-10-26 |
IL254262A0 (en) | 2017-10-31 |
KR20170123642A (ko) | 2017-11-08 |
RU2017131448A (ru) | 2019-04-08 |
US20180042921A1 (en) | 2018-02-15 |
JP2018507245A (ja) | 2018-03-15 |
RU2728796C2 (ru) | 2020-07-31 |
CA2978679A1 (en) | 2016-09-15 |
CN107530340A (zh) | 2018-01-02 |
US20190000841A1 (en) | 2019-01-03 |
EP3265091A1 (en) | 2018-01-10 |
US10076518B2 (en) | 2018-09-18 |
JP2021091695A (ja) | 2021-06-17 |
AU2016229295A1 (en) | 2017-09-28 |
HK1250007A1 (zh) | 2018-11-23 |
ZA201706035B (en) | 2019-12-18 |
SG11201707128TA (en) | 2017-09-28 |
JP7264331B2 (ja) | 2023-04-25 |
EP3265091A4 (en) | 2018-08-01 |
US10357491B2 (en) | 2019-07-23 |
CL2017002242A1 (es) | 2018-04-02 |
MX385914B (es) | 2025-03-18 |
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