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BR112016005897A2 - derivado de triazina - Google Patents

derivado de triazina

Info

Publication number
BR112016005897A2
BR112016005897A2 BR112016005897A BR112016005897A BR112016005897A2 BR 112016005897 A2 BR112016005897 A2 BR 112016005897A2 BR 112016005897 A BR112016005897 A BR 112016005897A BR 112016005897 A BR112016005897 A BR 112016005897A BR 112016005897 A2 BR112016005897 A2 BR 112016005897A2
Authority
BR
Brazil
Prior art keywords
group
substituent group
triazine derivative
atom
substituent
Prior art date
Application number
BR112016005897A
Other languages
English (en)
Inventor
Sawa Masaaki
Miyake Takahiro
Asami Tokiko
Kawahata Wataru
Original Assignee
Carna Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carna Biosciences Inc filed Critical Carna Biosciences Inc
Publication of BR112016005897A2 publication Critical patent/BR112016005897A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

fornecer um novo derivado de triazina. um derivado de tri-azina ou sal farmaceuticamente aceitável deste representado pela fórmula (i). (na fórmula: r1 representa um grupo alquila inferior que pode ter um grupo substituinte, ou um grupo alcóxi que pode ter um grupo substituinte; ar representa um grupo arila que pode ter um grupo substituinte, ou um grupo heteroarila que pode ter um grupo substituinte; um de z1 e z2 representa um átomo de carbono, enquanto o outro representa um átomo de nitrogênio, ou ambos simultaneamente repre-sentam átomos de nitrogênio; q representa uma estrutura selecionada da estrutura (a) e a estrutura (b); r2 representa um grupo alquila inferior que pode ter um grupo substituinte, ou um grupo cicloalquila que pode ter um grupo substituinte; r3 representa um átomo de hidrogênio ou um átomo de halogênio; y representa um átomo de nitrogênio ou um átomo de carbono; e a linha dupla compreendendo uma linha tracejada e uma linha sólida na estrutura (a) representa uma ligação dupla ou uma ligação simples).
BR112016005897A 2013-09-20 2014-09-12 derivado de triazina BR112016005897A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013194978 2013-09-20
PCT/JP2014/074169 WO2015041155A1 (ja) 2013-09-20 2014-09-12 新規トリアジン誘導体

Publications (1)

Publication Number Publication Date
BR112016005897A2 true BR112016005897A2 (pt) 2017-08-01

Family

ID=52688806

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016005897A BR112016005897A2 (pt) 2013-09-20 2014-09-12 derivado de triazina

Country Status (11)

Country Link
US (1) US20160221991A1 (pt)
EP (1) EP3048102A1 (pt)
JP (1) JPWO2015041155A1 (pt)
KR (1) KR20160045906A (pt)
CN (1) CN105745203A (pt)
AU (1) AU2014322239A1 (pt)
BR (1) BR112016005897A2 (pt)
CA (1) CA2925177A1 (pt)
IL (1) IL244664A0 (pt)
RU (1) RU2016115050A (pt)
WO (1) WO2015041155A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3546462B1 (en) * 2016-11-25 2024-01-03 Carna Biosciences, Inc. Novel oxoisoquinoline derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7205298B2 (en) * 2002-07-18 2007-04-17 Janssen Pharmaceutica N.V. Substituted triazine kinase inhibitors
BR112014003582A2 (pt) * 2011-08-17 2017-03-14 Hoffmann La Roche inibidores da tirosina quinase de bruton
JP5976826B2 (ja) * 2011-11-03 2016-08-24 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｂｔｋ活性阻害剤としての８−フルオロフタラジン−１（２ｈ）−オン化合物
CN103998447A (zh) * 2011-12-09 2014-08-20 弗·哈夫曼-拉罗切有限公司 布鲁顿酪氨酸激酶抑制剂
CN104169260A (zh) * 2012-03-09 2014-11-26 卡尔那生物科学株式会社 新三嗪衍生物
SG11201600497VA (en) * 2013-07-26 2016-02-26 Carna Biosciences Inc Novel triazine derivative
US20160207906A1 (en) * 2013-09-03 2016-07-21 Carna Biosciences, Inc. Novel 2,6-diaminopyrimidine derivative

Also Published As

Publication number Publication date
EP3048102A1 (en) 2016-07-27
KR20160045906A (ko) 2016-04-27
IL244664A0 (en) 2016-04-21
JPWO2015041155A1 (ja) 2017-03-02
US20160221991A1 (en) 2016-08-04
RU2016115050A (ru) 2017-10-25
CA2925177A1 (en) 2015-03-26
AU2014322239A1 (en) 2016-04-14
CN105745203A (zh) 2016-07-06
WO2015041155A1 (ja) 2015-03-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]