BR112015009589A2 - processos de produção de um animal de produção não humano, animal de produção geneticamente modificado não humano, organismo in vitro não humano escolhido do grupo que consiste em uma célula ou um animal blastocisto, o organismo in vitro, processo de produção de uma célula de animal de produção geneticamente modificado não humano, animal de produção não humano e método de produção de um animal de produção geneticamente modificado não humano - Google Patents
processos de produção de um animal de produção não humano, animal de produção geneticamente modificado não humano, organismo in vitro não humano escolhido do grupo que consiste em uma célula ou um animal blastocisto, o organismo in vitro, processo de produção de uma célula de animal de produção geneticamente modificado não humano, animal de produção não humano e método de produção de um animal de produção geneticamente modificado não humanoInfo
- Publication number
- BR112015009589A2 BR112015009589A2 BR112015009589A BR112015009589A BR112015009589A2 BR 112015009589 A2 BR112015009589 A2 BR 112015009589A2 BR 112015009589 A BR112015009589 A BR 112015009589A BR 112015009589 A BR112015009589 A BR 112015009589A BR 112015009589 A2 BR112015009589 A2 BR 112015009589A2
- Authority
- BR
- Brazil
- Prior art keywords
- animal
- production
- human
- genetically modified
- cell
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 11
- 238000004519 manufacturing process Methods 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 2
- 238000000338 in vitro Methods 0.000 title 2
- 210000004102 animal cell Anatomy 0.000 title 1
- 210000002459 blastocyst Anatomy 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 230000002779 inactivation Effects 0.000 abstract 2
- 244000144972 livestock Species 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000035938 sexual maturation Effects 0.000 abstract 2
- 230000000955 neuroendocrine Effects 0.000 abstract 1
- 230000032696 parturition Effects 0.000 abstract 1
- 230000001568 sexual effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8778—Swine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
Abstract
resumo controle da maturação sexual em animais um animal de pecuária geneticamente modificado compreendendo um genoma que compreende a inativação de um gene neuroendócrino seletivo para a maturação sexual, com a inativação do gene impedindo o animal de se tornar sexualmente maduro. os métodos de utilização e os processos de produção dos animais são ensinados. práticas de criação de animais convencionais focam o papel da maturidade sexual em animais de pecuária em termos de otimização da reprodução e parto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261720187P | 2012-10-30 | 2012-10-30 | |
US201361870510P | 2013-08-27 | 2013-08-27 | |
PCT/US2013/067502 WO2014070887A1 (en) | 2012-10-30 | 2013-10-30 | Control of sexual maturation in animals |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015009589A2 true BR112015009589A2 (pt) | 2017-11-14 |
Family
ID=50548813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015009589A BR112015009589A2 (pt) | 2012-10-30 | 2013-10-30 | processos de produção de um animal de produção não humano, animal de produção geneticamente modificado não humano, organismo in vitro não humano escolhido do grupo que consiste em uma célula ou um animal blastocisto, o organismo in vitro, processo de produção de uma célula de animal de produção geneticamente modificado não humano, animal de produção não humano e método de produção de um animal de produção geneticamente modificado não humano |
Country Status (15)
Country | Link |
---|---|
US (1) | US20140123330A1 (pt) |
EP (1) | EP2914714A4 (pt) |
JP (2) | JP2015533284A (pt) |
KR (1) | KR20150100651A (pt) |
CN (1) | CN105073981A (pt) |
AP (1) | AP2015008495A0 (pt) |
AR (1) | AR093291A1 (pt) |
AU (1) | AU2013337951B2 (pt) |
BR (1) | BR112015009589A2 (pt) |
CA (1) | CA2889502A1 (pt) |
MX (1) | MX2015005255A (pt) |
NZ (1) | NZ629578A (pt) |
PH (1) | PH12015500957A1 (pt) |
RU (1) | RU2015120467A (pt) |
WO (1) | WO2014070887A1 (pt) |
Families Citing this family (73)
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US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
LT2800811T (lt) | 2012-05-25 | 2017-09-11 | The Regents Of The University Of California | Būdai ir kompozicijos, skirti tikslinės dnr modifikavimui, panaudojant adresuotą rnr, ir transkripcijos moduliavimui, panaudojant adresuotą rnr |
EP3138911B1 (en) | 2012-12-06 | 2018-12-05 | Sigma Aldrich Co. LLC | Crispr-based genome modification and regulation |
ES2749624T3 (es) | 2013-03-14 | 2020-03-23 | Caribou Biosciences Inc | Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico |
US20140359796A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetically sterile animals |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
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JP2020511931A (ja) * | 2016-06-16 | 2020-04-23 | オスロ ウニヴェルスィテーツスィーケフース ハーエフOslo Universitetssykehus Hf | 改良された遺伝子編集 |
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AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
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CN110452995B (zh) * | 2019-08-27 | 2021-06-15 | 浙江大学 | 影响嘉兴黑猪母猪繁殖性能的gpr54基因分子标记及其应用 |
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SK282056B6 (sk) * | 1991-03-01 | 2001-10-08 | Merial | Spôsob zlepšenia organoleptických vlastností mäsa nevykastrovaných samcov domácich zvierat |
AU2003262379A1 (en) * | 2002-04-16 | 2003-11-03 | Auburn University | TRANSIENT AND/OR PERMANENT MODIFICATION OF SEXUAL BEHAVIOR AND/OR FERTILITY USING RECOMBINANT CHIMERIC GnRH |
ATE429496T1 (de) * | 2002-10-25 | 2009-05-15 | Takeda Pharmaceutical | Gpr54 'knock-out' säugetiere und screening- verfahren, die sie verwenden |
KR20120097483A (ko) * | 2009-07-24 | 2012-09-04 | 시그마-알드리치 컴퍼니., 엘엘씨 | 게놈 편집을 위한 방법 |
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KR20120038020A (ko) * | 2009-08-11 | 2012-04-20 | 상가모 바이오사이언스 인코포레이티드 | 표적화 변형에 대한 동형접합성 유기체 |
EP3456826B1 (en) * | 2009-12-10 | 2023-06-28 | Regents of the University of Minnesota | Tal effector-mediated dna modification |
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-
2013
- 2013-10-30 WO PCT/US2013/067502 patent/WO2014070887A1/en active Application Filing
- 2013-10-30 MX MX2015005255A patent/MX2015005255A/es unknown
- 2013-10-30 BR BR112015009589A patent/BR112015009589A2/pt not_active IP Right Cessation
- 2013-10-30 AP AP2015008495A patent/AP2015008495A0/xx unknown
- 2013-10-30 NZ NZ629578A patent/NZ629578A/en not_active IP Right Cessation
- 2013-10-30 AU AU2013337951A patent/AU2013337951B2/en not_active Ceased
- 2013-10-30 JP JP2015539942A patent/JP2015533284A/ja active Pending
- 2013-10-30 EP EP13851242.1A patent/EP2914714A4/en not_active Withdrawn
- 2013-10-30 KR KR1020157014564A patent/KR20150100651A/ko not_active Ceased
- 2013-10-30 RU RU2015120467A patent/RU2015120467A/ru not_active Application Discontinuation
- 2013-10-30 CN CN201380067471.8A patent/CN105073981A/zh active Pending
- 2013-10-30 AR ARP130103958A patent/AR093291A1/es unknown
- 2013-10-30 CA CA2889502A patent/CA2889502A1/en not_active Abandoned
- 2013-10-30 US US14/067,634 patent/US20140123330A1/en not_active Abandoned
-
2015
- 2015-04-29 PH PH12015500957A patent/PH12015500957A1/en unknown
-
2018
- 2018-10-25 JP JP2018200938A patent/JP2019047794A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NZ629578A (en) | 2017-06-30 |
AP2015008495A0 (en) | 2015-05-31 |
EP2914714A4 (en) | 2016-09-21 |
KR20150100651A (ko) | 2015-09-02 |
EP2914714A1 (en) | 2015-09-09 |
AU2013337951B2 (en) | 2019-10-03 |
RU2015120467A (ru) | 2016-12-20 |
JP2019047794A (ja) | 2019-03-28 |
AU2013337951A1 (en) | 2015-06-11 |
PH12015500957A1 (en) | 2015-08-10 |
US20140123330A1 (en) | 2014-05-01 |
AR093291A1 (es) | 2015-05-27 |
JP2015533284A (ja) | 2015-11-24 |
CA2889502A1 (en) | 2014-05-08 |
WO2014070887A1 (en) | 2014-05-08 |
CN105073981A (zh) | 2015-11-18 |
MX2015005255A (es) | 2015-10-29 |
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