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BR112015000657A8 - uso de uma célula geneticamente modificada para expressar um car. - Google Patents

uso de uma célula geneticamente modificada para expressar um car.

Info

Publication number
BR112015000657A8
BR112015000657A8 BR112015000657A BR112015000657A BR112015000657A8 BR 112015000657 A8 BR112015000657 A8 BR 112015000657A8 BR 112015000657 A BR112015000657 A BR 112015000657A BR 112015000657 A BR112015000657 A BR 112015000657A BR 112015000657 A8 BR112015000657 A8 BR 112015000657A8
Authority
BR
Brazil
Prior art keywords
car
genetically modified
express
modified cell
individual
Prior art date
Application number
BR112015000657A
Other languages
English (en)
Other versions
BR112015000657B1 (pt
BR112015000657A2 (pt
Inventor
L Levine Bruce
H June Carl
D Kalos Michael
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of BR112015000657A2 publication Critical patent/BR112015000657A2/pt
Publication of BR112015000657A8 publication Critical patent/BR112015000657A8/pt
Publication of BR112015000657B1 publication Critical patent/BR112015000657B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1 / 1 resumo “mã‰todos para depletar cã‰lulas b em um indivãduo, para promover tolerã‚ncia em um indivãduo e para tratar doenã‡a do enxerto versus hospedeiro” a presente invenã§ã£o fornece composiã§ãµes e mã©todos para induzir tolerã¢ncia em um humano. a invenã§ã£o inclui administrar uma cã©lula t geneticamente modificada que expressa um car em que o car compreende um domã­nio de ligaã§ã£o de antã­geno, um domã­nio de transmembrana, uma regiã£o de sinalizaã§ã£o coestimulatã³ria, e um domã­nio de sinalizaã§ã£o zeta de cd3.
BR112015000657-4A 2012-07-13 2013-07-12 Uso de uma célula geneticamente modificada para expressar um car BR112015000657B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261671508P 2012-07-13 2012-07-13
US61/671,508 2012-07-13
PCT/US2013/050293 WO2014012001A2 (en) 2012-07-13 2013-07-12 Use of cart19 to deplete normal b cells to induce tolerance

Publications (3)

Publication Number Publication Date
BR112015000657A2 BR112015000657A2 (pt) 2017-06-27
BR112015000657A8 true BR112015000657A8 (pt) 2018-01-16
BR112015000657B1 BR112015000657B1 (pt) 2023-12-05

Family

ID=49916701

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015000657-4A BR112015000657B1 (pt) 2012-07-13 2013-07-12 Uso de uma célula geneticamente modificada para expressar um car

Country Status (13)

Country Link
US (3) US20150290244A1 (pt)
EP (1) EP2872184B1 (pt)
JP (4) JP2015523386A (pt)
KR (1) KR102216083B1 (pt)
CN (1) CN104884095A (pt)
AU (3) AU2013289984B2 (pt)
BR (1) BR112015000657B1 (pt)
CA (1) CA2876734A1 (pt)
EA (2) EA201992742A3 (pt)
ES (1) ES2835232T3 (pt)
IN (1) IN2015DN00139A (pt)
MX (2) MX382772B (pt)
WO (1) WO2014012001A2 (pt)

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US20180264038A1 (en) * 2015-09-28 2018-09-20 Regents Of The University Of Minnesota Chimeric antigen receptor (car) t cells as therapeutic interventions for auto- and allo-immunity
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Also Published As

Publication number Publication date
MX2018009820A (es) 2022-08-24
US20150290244A1 (en) 2015-10-15
ES2835232T3 (es) 2021-06-22
AU2018203756A1 (en) 2018-06-21
AU2013289984B2 (en) 2018-03-08
CN104884095A (zh) 2015-09-02
EP2872184B1 (en) 2020-09-16
JP2015523386A (ja) 2015-08-13
MX382772B (es) 2025-03-11
MX2015000433A (es) 2016-04-28
AU2018203756B2 (en) 2019-10-24
CA2876734A1 (en) 2014-01-16
BR112015000657B1 (pt) 2023-12-05
EP2872184A4 (en) 2016-03-30
JP2018135363A (ja) 2018-08-30
IN2015DN00139A (pt) 2015-06-12
KR20150030750A (ko) 2015-03-20
AU2020200315B2 (en) 2021-11-04
EA201992742A3 (ru) 2020-12-30
EA201590209A1 (ru) 2015-08-31
JP2022173331A (ja) 2022-11-18
JP2020158541A (ja) 2020-10-01
AU2013289984A1 (en) 2015-01-22
EA034644B1 (ru) 2020-03-02
BR112015000657A2 (pt) 2017-06-27
WO2014012001A2 (en) 2014-01-16
US20240261328A1 (en) 2024-08-08
EA201992742A2 (ru) 2020-09-30
US20180271907A1 (en) 2018-09-27
WO2014012001A3 (en) 2015-04-23
EP2872184A2 (en) 2015-05-20
AU2020200315A1 (en) 2020-02-06
KR102216083B1 (ko) 2021-02-17

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Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
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