BR112014017749A2 - Composto alquinilbenzeno 3,5-dissubstituído e sal do mesmo - Google Patents
Composto alquinilbenzeno 3,5-dissubstituído e sal do mesmoInfo
- Publication number
- BR112014017749A2 BR112014017749A2 BR112014017749A BR112014017749A BR112014017749A2 BR 112014017749 A2 BR112014017749 A2 BR 112014017749A2 BR 112014017749 A BR112014017749 A BR 112014017749A BR 112014017749 A BR112014017749 A BR 112014017749A BR 112014017749 A2 BR112014017749 A2 BR 112014017749A2
- Authority
- BR
- Brazil
- Prior art keywords
- alknylbenzene
- displaced
- composite
- salt
- same
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-009467 | 2012-01-19 | ||
| JP2012009467 | 2012-01-19 | ||
| PCT/JP2013/050740 WO2013108809A1 (ja) | 2012-01-19 | 2013-01-17 | ３，５－二置換ベンゼンアルキニル化合物及びその塩 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112014017749A2 true BR112014017749A2 (pt) | 2017-06-20 |
| BR112014017749A8 BR112014017749A8 (pt) | 2017-07-11 |
| BR112014017749B1 BR112014017749B1 (pt) | 2021-08-03 |
Family
ID=48799233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014017749-0A BR112014017749B1 (pt) | 2012-01-19 | 2013-01-17 | Composto alquinilbenzeno 3,5-dissubstituído e sal do mesmo |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9108973B2 (pt) |
| EP (1) | EP2657233B1 (pt) |
| JP (1) | JP5355825B1 (pt) |
| KR (1) | KR101623286B1 (pt) |
| CN (1) | CN103958512B (pt) |
| AU (1) | AU2013210403B2 (pt) |
| BR (1) | BR112014017749B1 (pt) |
| CA (1) | CA2854093C (pt) |
| DK (1) | DK2657233T3 (pt) |
| ES (1) | ES2516392T3 (pt) |
| FI (1) | FIC20230038I1 (pt) |
| FR (1) | FR23C1050I2 (pt) |
| HU (1) | HUS2300043I1 (pt) |
| MX (1) | MX351513B (pt) |
| MY (1) | MY171055A (pt) |
| NL (1) | NL301254I2 (pt) |
| NO (1) | NO2023046I1 (pt) |
| PL (1) | PL2657233T3 (pt) |
| PT (1) | PT2657233E (pt) |
| RU (1) | RU2576384C1 (pt) |
| SG (1) | SG2014009286A (pt) |
| TW (1) | TWI508964B (pt) |
| WO (1) | WO2013108809A1 (pt) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| JP5873656B2 (ja) | 2011-06-13 | 2016-03-01 | 株式会社Ihi | 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤 |
| PT3495367T (pt) | 2012-06-13 | 2020-11-12 | Incyte Holdings Corp | Compostos tricíclicos substituídos como inibidores de fgfr |
| ES2916220T3 (es) | 2012-07-11 | 2022-06-29 | Blueprint Medicines Corp | Inhibidores del receptor de factor de crecimiento de fibroblasto |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| MX393494B (es) | 2013-04-19 | 2025-03-24 | Incyte Holdings Corp | Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr). |
| EP3023100B1 (en) * | 2013-07-18 | 2019-03-13 | Taiho Pharmaceutical Co., Ltd. | Antitumor drug for intermittent administration of fgfr inhibitor |
| ES2819398T3 (es) * | 2013-07-18 | 2021-04-15 | Taiho Pharmaceutical Co Ltd | Agente terapéutico para el cáncer resistente al inhibidor de FGFR |
| RU2666349C2 (ru) * | 2013-08-12 | 2018-09-07 | Тайхо Фармасьютикал Ко., Лтд. | Новое конденсированное пиримидиновое соединение или его соль |
| JP6458023B2 (ja) | 2013-10-25 | 2019-01-23 | ブループリント メディシンズ コーポレイション | 繊維芽細胞成長因子受容体の阻害剤 |
| WO2015099127A1 (ja) | 2013-12-27 | 2015-07-02 | 中外製薬株式会社 | Ｆｇｆｒゲートキーパー変異遺伝子およびそれを標的とする医薬 |
| US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| KR101947289B1 (ko) * | 2014-06-24 | 2019-02-12 | 다이호야쿠힌고교 가부시키가이샤 | 신규 피롤로피리미딘 화합물 또는 그의 염, 및 이것을 함유하는 의약 조성물, 특히 nae 저해 작용에 기초하는 종양 등의 예방제 및/또는 치료제 |
| RU2658821C1 (ru) | 2014-08-18 | 2018-06-25 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Соль моноциклического производного пиридина и ее кристалл |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| CN105837575B (zh) * | 2015-01-13 | 2019-01-15 | 四川大学 | 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途 |
| MY197518A (en) * | 2015-01-30 | 2023-06-19 | Taiho Pharmaceutical Co Ltd | Preventive and/or therapeutic agent of immune disease |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| CR20170390A (es) | 2015-02-20 | 2017-10-23 | Incyte Holdings Corp | Heterociclos biciclicos como inhibidores de fgfr |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| RU2672563C1 (ru) * | 2015-03-31 | 2018-11-16 | Тайхо Фармасьютикал Ко., Лтд. | Кристаллы 3,5-дизамещенного бензолалкинильного соединения |
| WO2016204261A1 (ja) | 2015-06-17 | 2016-12-22 | 中外製薬株式会社 | アミノピラゾール誘導体 |
| TWI659957B (zh) * | 2015-09-01 | 2019-05-21 | 大鵬藥品工業股份有限公司 | 新穎吡唑并［3,4-d］嘧啶化合物或其鹽 |
| TWI623316B (zh) * | 2015-12-22 | 2018-05-11 | Taiho Pharmaceutical Co Ltd | Antitumor effect enhancer derived from pyrrolopyrimidine compound |
| TWI687422B (zh) * | 2016-02-23 | 2020-03-11 | 日商大鵬藥品工業股份有限公司 | 新穎稠合嘧啶化合物或其鹽 |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| EP3424505A4 (en) * | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS |
| CN107344940B (zh) * | 2016-05-06 | 2020-04-21 | 广东东阳光药业有限公司 | Btk抑制剂及其用途 |
| CN107698593A (zh) * | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| JP7223684B2 (ja) * | 2017-02-28 | 2023-02-16 | 大鵬薬品工業株式会社 | ピラゾロ［３，４－ｄ］ピリミジン化合物を用いた抗腫瘍効果増強剤 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| JOP20180094A1 (ar) | 2017-10-18 | 2019-04-18 | Hk Inno N Corp | مركب حلقي غير متجانس كمثبط بروتين كيناز |
| CN109776544B (zh) * | 2017-11-15 | 2022-02-01 | 上海医药工业研究院 | 吡唑并[3,4-d]嘧啶类化合物及其制备方法和用途 |
| AU2019239404B2 (en) | 2018-03-19 | 2021-12-23 | Taiho Pharmaceutical Co., Ltd. | Pharmaceutical composition including sodium alkyl sulfate |
| CN111712245A (zh) | 2018-03-28 | 2020-09-25 | 卫材R&D管理有限公司 | 用于肝细胞癌的治疗剂 |
| US11174257B2 (en) | 2018-05-04 | 2021-11-16 | Incyte Corporation | Salts of an FGFR inhibitor |
| WO2019213544A2 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| WO2020007234A1 (zh) * | 2018-07-02 | 2020-01-09 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的炔基(杂)芳环类化合物 |
| KR102742083B1 (ko) * | 2018-11-09 | 2024-12-16 | 다이호야쿠힌고교 가부시키가이샤 | 디메톡시벤젠 화합물의 제조 방법 |
| JP7161546B2 (ja) * | 2018-11-09 | 2022-10-26 | 大鵬薬品工業株式会社 | ジメトキシベンゼン化合物の類縁物質、該化合物の分析方法及び標準品 |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| JPWO2020110974A1 (ja) * | 2018-11-26 | 2021-10-07 | 大鵬薬品工業株式会社 | 線維芽細胞増殖因子受容体阻害剤と内分泌療法との併用による内分泌療法が適用される腫瘍の治療及び予防方法 |
| WO2020170355A1 (ja) * | 2019-02-20 | 2020-08-27 | 大鵬薬品工業株式会社 | Ｆｇｆｒ１変異腫瘍の治療方法 |
| JPWO2020175704A1 (pt) * | 2019-02-28 | 2020-09-03 | ||
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN114126620B (zh) * | 2019-05-13 | 2024-12-31 | 传达治疗有限公司 | Fgfr抑制剂和其使用方法 |
| JP2022533939A (ja) * | 2019-05-17 | 2022-07-27 | キネート バイオファーマ インク． | 線維芽細胞増殖因子受容体キナーゼの阻害剤 |
| JP7574184B2 (ja) | 2019-06-21 | 2024-10-28 | 大鵬薬品工業株式会社 | 悪性腫瘍の治療方法 |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076602A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN114641293B (zh) * | 2019-11-08 | 2024-05-31 | 石药集团中奇制药技术（石家庄）有限公司 | 一种fgfr抑制剂的用途 |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| PE20221504A1 (es) | 2019-12-04 | 2022-09-30 | Incyte Corp | Derivados de un inhibidor de fgfr |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| TWI857207B (zh) | 2020-01-31 | 2024-10-01 | 國立大學法人京都大學 | 軟骨發育異常症之治療 |
| CA3181162A1 (en) | 2020-06-05 | 2021-12-09 | Stephen W. Kaldor | Inhibitors of fibroblast growth factor receptor kinases |
| TW202216151A (zh) * | 2020-07-15 | 2022-05-01 | 日商大鵬藥品工業股份有限公司 | 含有使用於腫瘤之治療之嘧啶化合物之組合 |
| TWI797711B (zh) * | 2020-08-13 | 2023-04-01 | 大陸商上海和譽生物醫藥科技有限公司 | 一種fgfr及其突變抑制劑，其製備方法和應用 |
| CN115867547B (zh) * | 2020-08-27 | 2024-12-20 | 上海和誉生物医药科技有限公司 | 一种1h-吡唑-4-酰胺衍生物，其制备方法和应用 |
| TW202233625A (zh) * | 2020-11-18 | 2022-09-01 | 美商傳達治療有限公司 | Ｆｇｆｒ抑制劑及其製造及使用方法 |
| CN114805359B (zh) * | 2021-01-28 | 2023-10-27 | 药雅科技(上海)有限公司 | 炔代杂环化合物fgfr抑制剂的制备方法和用途 |
| CN115028634B (zh) * | 2021-03-08 | 2023-11-28 | 药雅科技(上海)有限公司 | 一种炔代吡嗪并杂环类fgfr抑制剂及其制备方法和用途 |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| CN115785103A (zh) * | 2022-12-28 | 2023-03-14 | 北京康立生医药技术开发有限公司 | 一种治疗胆管癌药物福巴替尼的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200738725A (en) | 2006-01-25 | 2007-10-16 | Osi Pharm Inc | Unsaturated mTOR inhibitors |
| KR101425248B1 (ko) * | 2007-03-28 | 2014-08-06 | 파마시클릭스, 인코포레이티드 | 브루톤 티로신 키나제의 억제제 |
| GB0819105D0 (en) * | 2008-10-17 | 2008-11-26 | Chroma Therapeutics Ltd | Pyrrolo-pyrimidine compounds |
| KR101483215B1 (ko) * | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
| SG186077A1 (en) | 2010-06-03 | 2013-01-30 | Pharmacyclics Inc | The use of inhibitors of bruton's tyrosine kinase (btk) |
-
2013
- 2013-01-17 PL PL13728918T patent/PL2657233T3/pl unknown
- 2013-01-17 CN CN201380003870.8A patent/CN103958512B/zh active Active
- 2013-01-17 SG SG2014009286A patent/SG2014009286A/en unknown
- 2013-01-17 RU RU2014133907/04A patent/RU2576384C1/ru active
- 2013-01-17 JP JP2013523428A patent/JP5355825B1/ja active Active
- 2013-01-17 MY MYPI2014700531A patent/MY171055A/en unknown
- 2013-01-17 EP EP13728918.7A patent/EP2657233B1/en active Active
- 2013-01-17 AU AU2013210403A patent/AU2013210403B2/en active Active
- 2013-01-17 CA CA2854093A patent/CA2854093C/en active Active
- 2013-01-17 US US14/344,935 patent/US9108973B2/en active Active
- 2013-01-17 KR KR1020147013608A patent/KR101623286B1/ko active Active
- 2013-01-17 MX MX2014008605A patent/MX351513B/es active IP Right Grant
- 2013-01-17 BR BR112014017749-0A patent/BR112014017749B1/pt active IP Right Grant
- 2013-01-17 PT PT137289187T patent/PT2657233E/pt unknown
- 2013-01-17 WO PCT/JP2013/050740 patent/WO2013108809A1/ja active Application Filing
- 2013-01-17 ES ES13728918.7T patent/ES2516392T3/es active Active
- 2013-01-17 DK DK13728918.7T patent/DK2657233T3/da active
- 2013-01-18 TW TW102102005A patent/TWI508964B/zh active
-
2023
- 2023-12-18 NL NL301254C patent/NL301254I2/nl unknown
- 2023-12-18 FI FIC20230038C patent/FIC20230038I1/fi unknown
- 2023-12-19 FR FR23C1050C patent/FR23C1050I2/fr active Active
- 2023-12-20 NO NO2023046C patent/NO2023046I1/no unknown
- 2023-12-21 HU HUS2300043C patent/HUS2300043I1/hu unknown
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