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BR112014005538A2 - composições aquosas compreendendo arbecacina - Google Patents

composições aquosas compreendendo arbecacina

Info

Publication number
BR112014005538A2
BR112014005538A2 BR112014005538A BR112014005538A BR112014005538A2 BR 112014005538 A2 BR112014005538 A2 BR 112014005538A2 BR 112014005538 A BR112014005538 A BR 112014005538A BR 112014005538 A BR112014005538 A BR 112014005538A BR 112014005538 A2 BR112014005538 A2 BR 112014005538A2
Authority
BR
Brazil
Prior art keywords
arbecacin
compositions
aqueous compositions
relates
aqueous
Prior art date
Application number
BR112014005538A
Other languages
English (en)
Inventor
Shoji Kuniko
Keller Manfred
Tanaka Masashi
Hahn Michael
Sano Nao
Egle Roman
Sugano Toshie
Yagi Yukihiro
Original Assignee
Meiji Seika Pharma Co Ltd
Pari Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Pharma Co Ltd, Pari Pharma Gmbh filed Critical Meiji Seika Pharma Co Ltd
Publication of BR112014005538A2 publication Critical patent/BR112014005538A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

resumo patente de invenção: "composições aquosas compreendendo arbecacina". a invenção refere-se a composições aquosas farmacêuticas líquidas que compreendem íons de cloreto e arbecacina. as composições são bem toleráveis para uso em um método para o tratamento ou a prevenção de uma doença do trato respiratório superior ou inferior, em que a composição é aerossolizada e inalada pelo paciente. além disso, a invenção refere-se ao cloridrato de arbecacina.
BR112014005538A 2011-09-12 2012-08-03 composições aquosas compreendendo arbecacina BR112014005538A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11180927.3A EP2567691B1 (en) 2011-09-12 2011-09-12 Aqueous compositions comprising arbekacin
PCT/EP2012/065265 WO2013037566A1 (en) 2011-09-12 2012-08-03 Aqueous compositions comprising arbekacin

Publications (1)

Publication Number Publication Date
BR112014005538A2 true BR112014005538A2 (pt) 2017-03-21

Family

ID=46642515

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014005538A BR112014005538A2 (pt) 2011-09-12 2012-08-03 composições aquosas compreendendo arbecacina

Country Status (15)

Country Link
US (1) US9511143B2 (pt)
EP (2) EP2567691B1 (pt)
JP (1) JP6072801B2 (pt)
KR (1) KR101944571B1 (pt)
CN (1) CN103826611B (pt)
AU (1) AU2012307661B2 (pt)
BR (1) BR112014005538A2 (pt)
CA (1) CA2844923C (pt)
ES (2) ES2532667T3 (pt)
MX (1) MX357556B (pt)
PL (2) PL2567691T3 (pt)
PT (2) PT2567691E (pt)
RU (1) RU2604767C2 (pt)
UA (1) UA113966C2 (pt)
WO (1) WO2013037566A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013010041A1 (en) 2011-07-12 2013-01-17 Cardeas Pharma Inc. Formulations of amikacin and fosfomycin combinations and methods and systems for treatment of ventilator associated pneumonia (vap) and ventilator associated tracheal (vat) bronchitis
CN105246907B (zh) * 2013-05-30 2017-12-01 明治制果药业株式会社 阿贝卡星衍生物及其制造和利用
KR20160048896A (ko) 2013-08-26 2016-05-04 카르데아스 파마 코포레이션 화학적 특성이 개선된 아미노글리코시드 및 포스포마이신의 조합 제제
ES2867152T3 (es) * 2015-04-22 2021-10-20 Matinas Biopharma Nanotechnologies Inc Composiciones y métodos para el tratamiento de infecciones y enfermedad pulmonar por micobacterias
BR112018074532B1 (pt) 2016-05-31 2022-02-08 Polyphor Ag Composição farmacêutica, aerossol, e, kit.
CN110483597A (zh) * 2019-09-07 2019-11-22 常州方圆制药有限公司 阿贝卡星盐酸盐的假多晶型、其制备方法及其应用
KR20240134913A (ko) 2022-01-21 2024-09-10 센주 유에스에이, 인코포레이티드 수성 액제

Family Cites Families (21)

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US4029882A (en) * 1974-03-19 1977-06-14 Schering Corporation Selective acylation of the C-1 amino group of aminoglycoside antibiotics
JPS5651499A (en) 1979-10-01 1981-05-09 Meiji Seika Kaisha Ltd Aminoglycoside derivative and its preparation
JPS58134099A (ja) 1982-02-05 1983-08-10 Meiji Seika Kaisha Ltd アミノ配糖体抗生物質の精製法
JP3215759B2 (ja) 1993-09-09 2001-10-09 財団法人微生物化学研究会 耐性菌に有効な５−置換−２″−アミノ−２″−デオキシアルベカシンとその製造法
JP3215732B2 (ja) 1992-11-27 2001-10-09 財団法人微生物化学研究会 耐性菌に有効なジベカシン誘導体またはアルベカシン誘導体とそれらの製造法
US5958449A (en) 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
US5508269A (en) 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
JP3213687B2 (ja) * 1995-10-09 2001-10-02 財団法人微生物化学研究会 アルベカシンと（−）−シス−１，２−エポキシプロピルホスホン酸との付加塩およびその製造法、ならびに抗菌剤
JP2001161789A (ja) 1999-12-07 2001-06-19 Sawai Pharmaceutical Co Ltd 水性注射剤
DK1273292T3 (da) 2001-07-02 2004-10-04 Chiesi Farma Spa Optimeret tobramycinformulering til aerosoldannelse
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US20070071686A1 (en) 2003-10-15 2007-03-29 Pari Gmbh Liquid preparation containing tobramycin
AU2005244153B2 (en) 2004-05-17 2009-10-29 Corus Pharma, Inc. Aerosolized fosfomycin/aminoglycoside combination for the treatment of bacterial respiratory infections
DE102005038619A1 (de) 2005-08-16 2007-02-22 Pari GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments
ES2666276T3 (es) * 2006-10-11 2018-05-03 Laboratoires Smb Sa Composición farmacéutica antiinfecciosa para inhalación
EP2030644A1 (en) 2007-08-31 2009-03-04 PARI Pharma GmbH Aerosols for sinunasal drug delivery
DE102007056462B4 (de) 2007-11-23 2011-10-27 Pari Pharma Gmbh Einwegampulle für eine Vorrichtung zur Erzeugung von Aerosolen
DE102008022987A1 (de) 2008-05-09 2009-11-12 Pari Pharma Gmbh Vernebler für Beatmungsmaschinen und Beatmungsmaschine mit einem solchen Vernebler
CN101575354B (zh) 2009-05-26 2013-03-13 北京化工大学 阿贝卡星及其中间体地贝卡星的合成方法
CN102655855B (zh) * 2009-12-14 2015-03-11 奇斯药制品公司 用于吸入的抗生素微粒
JP5651499B2 (ja) 2011-03-01 2015-01-14 カヤバ工業株式会社 フロントフォーク用の姿勢維持具

Also Published As

Publication number Publication date
RU2014114512A (ru) 2015-10-27
PT2567691E (pt) 2015-04-09
CA2844923C (en) 2019-04-30
CN103826611A (zh) 2014-05-28
CN103826611B (zh) 2016-10-19
WO2013037566A1 (en) 2013-03-21
AU2012307661B2 (en) 2017-02-02
KR101944571B1 (ko) 2019-01-31
EP2567691A1 (en) 2013-03-13
PT2755635E (pt) 2016-02-10
EP2567691B1 (en) 2014-12-24
US9511143B2 (en) 2016-12-06
RU2604767C2 (ru) 2016-12-10
MX357556B (es) 2018-07-13
EP2755635B1 (en) 2015-10-14
ES2532667T3 (es) 2015-03-30
US20140343005A1 (en) 2014-11-20
JP6072801B2 (ja) 2017-02-01
PL2567691T3 (pl) 2015-05-29
CA2844923A1 (en) 2013-03-21
JP2014526481A (ja) 2014-10-06
PL2755635T3 (pl) 2016-03-31
MX2014002465A (es) 2014-08-01
KR20140090598A (ko) 2014-07-17
EP2755635A1 (en) 2014-07-23
UA113966C2 (xx) 2017-04-10
ES2555462T3 (es) 2016-01-04
AU2012307661A1 (en) 2014-02-20

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07E Notice of approval relating to section 229 industrial property law
B06T Formal requirements before examination
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law
B09B Decision: refusal
B09B Decision: refusal

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