BR112013027652A2 - processo para preparar um composto - Google Patents

processo para preparar um composto

Info

Publication number: BR112013027652A2
Authority: BR; Brazil
Prior art keywords: preparing; compound
Prior art date: 2011-05-04

Application number

BR112013027652A

Other languages

English (en)

Inventor

Frank Chen

George Wu

Ji Xie

Joseph Lamberson

Marc Poirier

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-05-04

Filing date

2012-05-02

Publication date

2016-07-26

2012-05-02 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2016-07-26 Publication of BR112013027652A2 publication Critical patent/BR112013027652A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Analytical Chemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

BR112013027652A 2011-05-04 2012-05-02 processo para preparar um composto BR112013027652A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161482592P	2011-05-04	2011-05-04
PCT/US2012/036112 WO2012151271A1 (en)	2011-05-04	2012-05-02	Processes for preparing inhibitors of the hepatitis c virus

Publications (1)

Publication Number	Publication Date
BR112013027652A2 true BR112013027652A2 (pt)	2016-07-26

Family

ID=47108028

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BR112013027642A BR112013027642A2 (pt)	2011-05-04	2012-05-02	substância medicamentosa, composição farmacêutica, processo para isolar uma substância medicamentosa, e, usos da substância medicamentosa, do processo, e da composição farmacêutica
BR112013027652A BR112013027652A2 (pt)	2011-05-04	2012-05-02	processo para preparar um composto

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BR112013027642A BR112013027642A2 (pt)	2011-05-04	2012-05-02	substância medicamentosa, composição farmacêutica, processo para isolar uma substância medicamentosa, e, usos da substância medicamentosa, do processo, e da composição farmacêutica

Country Status (17)

Country	Link
US (2)	US20140058116A1 (pt)
EP (2)	EP2704570A4 (pt)
JP (2)	JP2014513127A (pt)
KR (2)	KR20140030169A (pt)
CN (2)	CN103476260A (pt)
AR (1)	AR086259A1 (pt)
AU (2)	AU2012250811A1 (pt)
BR (2)	BR112013027642A2 (pt)
CA (2)	CA2832869A1 (pt)
CO (1)	CO6801768A2 (pt)
IL (1)	IL228601A0 (pt)
MX (2)	MX2013012773A (pt)
RU (2)	RU2013153533A (pt)
SG (1)	SG194711A1 (pt)
TW (1)	TW201247668A (pt)
WO (2)	WO2012151271A1 (pt)
ZA (1)	ZA201308011B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8828930B2 (en)	2009-07-30	2014-09-09	Merck Sharp & Dohme Corp.	Hepatitis C virus NS3 protease inhibitors
CN105555771B (zh) *	2013-06-19	2025-02-21	Aic246股份两合公司	无定形莱特莫韦及其用于口服施用的固体药物制剂
KR102676383B1 (ko) *	2017-03-07	2024-06-20	오리온 코포레이션	결정성 의약품의 제조
US11351149B2 (en)	2020-09-03	2022-06-07	Pfizer Inc.	Nitrile-containing antiviral compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR044694A1 (es) *	2003-06-17	2005-09-21	Schering Corp	Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
AR056805A1 (es) *	2005-11-14	2007-10-24	Schering Corp	Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
CN101495095B (zh) *	2006-04-28	2013-05-29	默沙东公司	通过受控的沉淀来沉淀和分离6,6-二甲基-3-氮杂-双环[3.1.0]己烷-酰胺化合物的方法和含有其的药学制剂
US8420122B2 (en) *	2006-04-28	2013-04-16	Merck Sharp & Dohme Corp.	Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
US8163937B2 (en) *	2006-12-20	2012-04-24	Schering Corporation	Process for preparing (1R,2S,5S)-N-[(1S)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]-carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
US8143402B2 (en) *	2007-02-01	2012-03-27	Tibotec Pharmaceuticals Ltd.	Polymorphic forms of a macrocyclic inhibitor of HCV
JP4803074B2 (ja) *	2007-03-06	2011-10-26	日産化学工業株式会社	アルコール酸化触媒およびその合成方法
NZ583825A (en) *	2007-09-14	2012-06-29	Schering Corp	Method of treating hepatitis C patients comprising an HCV protease inhibitor, an antiviral compound and an interferon
DE102009000662A1 (de) *	2009-02-06	2010-08-12	Evonik Degussa Gmbh	Verfahren zur Herstellung von Aldehyden und Ketonen aus primären und sekundären Alkoholen

2012
- 2012-05-02 MX MX2013012773A patent/MX2013012773A/es unknown
- 2012-05-02 KR KR1020137028709A patent/KR20140030169A/ko not_active Withdrawn
- 2012-05-02 AU AU2012250811A patent/AU2012250811A1/en not_active Abandoned
- 2012-05-02 CA CA2832869A patent/CA2832869A1/en not_active Abandoned
- 2012-05-02 JP JP2014509388A patent/JP2014513127A/ja active Pending
- 2012-05-02 SG SG2013080643A patent/SG194711A1/en unknown
- 2012-05-02 AU AU2012250799A patent/AU2012250799A1/en not_active Abandoned
- 2012-05-02 KR KR1020137028743A patent/KR20140022855A/ko not_active Withdrawn
- 2012-05-02 BR BR112013027642A patent/BR112013027642A2/pt not_active IP Right Cessation
- 2012-05-02 EP EP12779536.7A patent/EP2704570A4/en not_active Withdrawn
- 2012-05-02 CN CN2012800200308A patent/CN103476260A/zh active Pending
- 2012-05-02 US US14/114,251 patent/US20140058116A1/en not_active Abandoned
- 2012-05-02 RU RU2013153533/04A patent/RU2013153533A/ru not_active Application Discontinuation
- 2012-05-02 US US14/114,357 patent/US20140044759A1/en not_active Abandoned
- 2012-05-02 RU RU2013153588/15A patent/RU2013153588A/ru unknown
- 2012-05-02 CA CA2833887A patent/CA2833887A1/en not_active Abandoned
- 2012-05-02 EP EP12779558.1A patent/EP2704576A4/en not_active Withdrawn
- 2012-05-02 MX MX2013012771A patent/MX2013012771A/es unknown
- 2012-05-02 WO PCT/US2012/036112 patent/WO2012151271A1/en active Application Filing
- 2012-05-02 CN CN201280020032.7A patent/CN103501608A/zh active Pending
- 2012-05-02 BR BR112013027652A patent/BR112013027652A2/pt not_active IP Right Cessation
- 2012-05-02 WO PCT/US2012/036131 patent/WO2012151283A1/en active Application Filing
- 2012-05-02 JP JP2014509384A patent/JP2014515764A/ja active Pending
- 2012-05-03 AR ARP120101561A patent/AR086259A1/es not_active Application Discontinuation
- 2012-05-04 TW TW101116053A patent/TW201247668A/zh unknown
2013
- 2013-09-29 IL IL228601A patent/IL228601A0/en unknown
- 2013-10-29 ZA ZA2013/08011A patent/ZA201308011B/en unknown
- 2013-11-01 CO CO13259875A patent/CO6801768A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
ZA201308011B (en)	2015-05-27
MX2013012773A (es)	2013-11-21
TW201247668A (en)	2012-12-01
CN103476260A (zh)	2013-12-25
KR20140022855A (ko)	2014-02-25
EP2704570A4 (en)	2015-02-18
IL228601A0 (en)	2013-12-31
RU2013153588A (ru)	2015-06-10
WO2012151283A1 (en)	2012-11-08
AU2012250811A1 (en)	2013-12-19
EP2704576A1 (en)	2014-03-12
EP2704570A1 (en)	2014-03-12
CA2833887A1 (en)	2012-11-08
AR086259A1 (es)	2013-12-04
CN103501608A (zh)	2014-01-08
MX2013012771A (es)	2013-11-21
KR20140030169A (ko)	2014-03-11
BR112013027642A2 (pt)	2016-07-26
AU2012250799A1 (en)	2013-10-10
SG194711A1 (en)	2013-12-30
WO2012151271A1 (en)	2012-11-08
CO6801768A2 (es)	2013-11-29
CA2832869A1 (en)	2012-11-08
JP2014513127A (ja)	2014-05-29
EP2704576A4 (en)	2014-12-10
US20140044759A1 (en)	2014-02-13
US20140058116A1 (en)	2014-02-27
JP2014515764A (ja)	2014-07-03
RU2013153533A (ru)	2015-06-10
NZ617300A (en)	2015-06-26

Publication	Publication Date	Title
BR112014008196A2 (pt)	2017-04-18	processo para a preparação de um composto
BR112014012414A8 (pt)	2018-01-23	processo para a preparação de 5-flúor-1h-pirazolopiridinas substituídas
BRPI1012018A2 (pt)	2015-09-22	processo para preparar um composto
BR112015023670A2 (pt)	2017-07-18	processo para preparar um composto
BR112014003798A2 (pt)	2017-03-01	método para fabricar um composto, e, composto
BRPI0910910A2 (pt)	2015-09-29	processo para preparar um composto
BR112014011672A2 (pt)	2017-05-30	processo para preparar ácido levulínico
BR112013012108A2 (pt)	2017-11-07	processo para a preparação de um poliéster
BR112014003111A2 (pt)	2017-02-21	processo para preparar um composto de 1h-pirazol-5- carbonilcloreto n-substituído e processo para preparar um composto de sulfimina
BR112014004622A8 (pt)	2017-06-20	processo para a preparação de isocianatos
BR112015003101A2 (pt)	2017-07-04	processo para a preparação de um composto.
BR112014012243A2 (pt)	2017-05-30	processo de preparação de compostos
BR112013018945A2 (pt)	2017-05-02	processo para a preparação de 4-amino-5-fluoro-3-halo-6-(substituído)picolinatos.
BR112013022749A2 (pt)	2019-09-24	método para produzir um composto de cálcio-arsênico fracamente solúvel
BR112013031365A2 (pt)	2016-11-29	método para produzir um composto
BR112014015512A8 (pt)	2017-07-04	processo para a preparação de um composto
BR112014028589A2 (pt)	2017-07-25	processo para fabricação de compostos de ciclopentilpirimidina hidroxilada
BR112014003336A2 (pt)	2017-03-14	processo para a preparação de complexos de 68ga
ITMI20120227A1 (it)	2012-09-17	Procedimento per la regolazione di un processo di stampa
BR112013022548A2 (pt)	2016-12-06	processo para a preparação de aminas primárias
BR112014014291A2 (pt)	2017-06-13	processo para preparar um catalisador
BR112015000987A2 (pt)	2017-06-27	processo para a preparação de 5-fluoro-1h-pirazóis
BR112014010327A2 (pt)	2017-05-09	processo para a preparação de compostos
BR112014011737A2 (pt)	2017-10-24	processo para ligação de elementos funcionais a um eixo
BR112014014052A2 (pt)	2017-06-13	processo para a preparação de 5-hidroximetilfurfural

Legal Events

Date	Code	Title
2017-03-07	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2017-06-20	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
2021-06-01	B350	Update of information on the portal [chapter 15.35 patent gazette]