BR112012001344A2 - derivados de 17hidróxi-17-pentafluoroetil-estra-4,9(10)-dieno-11-arila, método de produção destes e uso destes para o tratamento de doenças - Google Patents

derivados de 17hidróxi-17-pentafluoroetil-estra-4,9(10)-dieno-11-arila, método de produção destes e uso destes para o tratamento de doenças

Info

Publication number: BR112012001344A2
Authority: BR; Brazil
Prior art keywords: 17hydroxy; estra; pentafluoroethyl; diene; diseases
Prior art date: 2009-07-20

Application number

BR112012001344A

Other languages

English (en)

Other versions

BR112012001344B1 (pt

BR112012001344B8 (pt

Inventor

Andrea Rotgeri

Carsten Möller

Ulrich Klar

Wilhelm Bone

Wolfgang Schwede

Original Assignee

Bayer Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-07-20

Filing date

2010-07-07

Publication date

2016-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43383964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012001344(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-07-07 Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG

2016-03-15 Publication of BR112012001344A2 publication Critical patent/BR112012001344A2/pt

2020-09-24 Publication of BR112012001344B1 publication Critical patent/BR112012001344B1/pt

2021-05-25 Publication of BR112012001344B8 publication Critical patent/BR112012001344B8/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Gynecology & Obstetrics (AREA)
Diabetes (AREA)
Pregnancy & Childbirth (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BR112012001344A 2009-07-20 2010-07-07 derivados de 17hidróxi-17-pentaflúoretil-estra-4,9(10)-dieno-11-arila, seus usos, e produto medicinal BR112012001344B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102009034362A DE102009034362A1 (de)	2009-07-20	2009-07-20	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362.8		2009-07-20
PCT/EP2010/004149 WO2011009531A2 (de)	2009-07-20	2010-07-07	17-hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-derivate, verfahren zu ihrer herstellung und ihre verwendung zur behandlung von krankheiten

Publications (3)

Publication Number	Publication Date
BR112012001344A2 true BR112012001344A2 (pt)	2016-03-15
BR112012001344B1 BR112012001344B1 (pt)	2020-09-24
BR112012001344B8 BR112012001344B8 (pt)	2021-05-25

Family

ID=43383964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR112012001344A BR112012001344B8 (pt)	2009-07-20	2010-07-07	derivados de 17hidróxi-17-pentaflúoretil-estra-4,9(10)-dieno-11-arila, seus usos, e produto medicinal

Country Status (47)

Country	Link
US (4)	US20120149670A1 (pt)
EP (4)	EP3252069B1 (pt)
JP (3)	JP5795312B2 (pt)
KR (2)	KR101687853B1 (pt)
CN (1)	CN102482317B (pt)
AR (1)	AR077491A1 (pt)
AU (1)	AU2010275849B2 (pt)
BR (1)	BR112012001344B8 (pt)
CA (1)	CA2768407C (pt)
CL (1)	CL2012000166A1 (pt)
CO (1)	CO6491067A2 (pt)
CR (2)	CR20170091A (pt)
CU (1)	CU20120012A7 (pt)
CY (3)	CY1114260T1 (pt)
DE (1)	DE102009034362A1 (pt)
DK (3)	DK3252069T3 (pt)
DO (2)	DOP2012000015A (pt)
EA (2)	EA021946B1 (pt)
EC (2)	ECSP12011616A (pt)
ES (3)	ES2416461T3 (pt)
GT (1)	GT201200012A (pt)
HN (1)	HN2012000137A (pt)
HR (3)	HRP20130558T1 (pt)
HU (2)	HUE043757T2 (pt)
IL (1)	IL216967B (pt)
IN (1)	IN2012DN00598A (pt)
JO (2)	JO3009B1 (pt)
LT (2)	LT2623510T (pt)
MA (1)	MA33445B1 (pt)
ME (2)	ME03400B (pt)
MX (2)	MX2012000930A (pt)
MY (1)	MY179447A (pt)
NO (1)	NO2623510T3 (pt)
NZ (2)	NZ623417A (pt)
PE (2)	PE20170084A1 (pt)
PL (3)	PL3252069T3 (pt)
PT (3)	PT2623510T (pt)
RS (1)	RS52811B (pt)
SG (3)	SG10201811830PA (pt)
SI (3)	SI2623510T1 (pt)
TN (1)	TN2012000028A1 (pt)
TR (1)	TR201908600T4 (pt)
TW (1)	TWI505830B (pt)
UA (1)	UA106502C2 (pt)
UY (1)	UY32791A (pt)
WO (1)	WO2011009531A2 (pt)
ZA (1)	ZA201201222B (pt)

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DE102009034366A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de)	2009-07-21	2011-02-10	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de)	2009-07-21	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
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EP2123279A1 (de)	2008-05-14	2009-11-25	Bayer Schering Pharma Aktiengesellschaft	Sequentielle Verabreichung von 20,20,21,21,21-Pentafluor-17-hydroxy-1 1beta-[4-(hydroxyacetyl) phenyl]-19-nor-17alpha-pregna-4,9-dien-3-on und einem oder mehreren Gestagenen zur Behandlung gynäkologischer Erkrankungen
DE102009034362A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten

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Publication number	Publication date
EA201200121A1 (ru)	2012-07-30
CR20120040A (es)	2012-03-12
ECSP18047708A (es)	2018-06-30
UA106502C2 (uk)	2014-09-10
JO3732B1 (ar)	2021-01-31
TWI505830B (zh)	2015-11-01
MX338217B (es)	2016-04-07
PT2432798E (pt)	2013-06-28
IL216967A0 (en)	2012-02-29
HRP20130558T1 (hr)	2013-07-31
EA021946B1 (ru)	2015-10-30
EP2432798A2 (de)	2012-03-28
EP2623510A1 (de)	2013-08-07
US20150342962A1 (en)	2015-12-03
DK2623510T3 (en)	2017-12-04
CA2768407A1 (en)	2011-01-27
ES2730209T3 (es)	2019-11-08
CY1121926T1 (el)	2020-10-14
SI2432798T1 (sl)	2013-08-30
GT201200012A (es)	2013-10-15
US20170202857A1 (en)	2017-07-20
UY32791A (es)	2011-02-28
SG10201404159VA (en)	2014-10-30
SI3252069T1 (sl)	2019-06-28
AU2010275849B2 (en)	2014-12-18
NZ597639A (en)	2014-04-30
NO2623510T3 (pt)	2018-01-20
ME03400B (me)	2020-01-20
CU20120012A7 (es)	2012-07-31
EP2623510B1 (de)	2017-08-23
JO3009B1 (ar)	2016-09-05
US20120094969A1 (en)	2012-04-19
TW201105331A (en)	2011-02-16
SG177519A1 (en)	2012-02-28
CN102482317A (zh)	2012-05-30
KR101854059B1 (ko)	2018-05-02
PL2432798T3 (pl)	2013-08-30
HRP20171805T1 (hr)	2017-12-29
BR112012001344B1 (pt)	2020-09-24
TN2012000028A1 (en)	2013-09-19
PT3252069T (pt)	2019-06-18
DOP2012000015A (es)	2016-04-15
HUE037339T2 (hu)	2018-08-28
CY1114260T1 (el)	2016-08-31
PL2623510T3 (pl)	2018-02-28
EA025150B1 (ru)	2016-11-30
DK2432798T3 (da)	2013-07-01
ME01534B (me)	2014-04-20
CL2012000166A1 (es)	2012-08-31
KR101687853B1 (ko)	2016-12-19
WO2011009531A2 (de)	2011-01-27
MA33445B1 (fr)	2012-07-03
IN2012DN00598A (pt)	2015-06-12
EP3252069B1 (de)	2019-04-03
CY1119661T1 (el)	2018-04-04
US9717739B2 (en)	2017-08-01
HN2012000137A (es)	2015-05-04
WO2011009531A3 (de)	2011-04-28
CN102482317B (zh)	2014-09-17
CR20170091A (es)	2018-02-06
LT3252069T (lt)	2019-06-10
DOP2015000276A (es)	2018-04-15
SI2623510T1 (sl)	2017-12-29
DE102009034362A1 (de)	2011-01-27
HRP20191049T1 (hr)	2019-09-20
HUE043757T2 (hu)	2019-09-30
JP6130087B1 (ja)	2017-05-17
EP3252069A1 (de)	2017-12-06
NZ623417A (en)	2015-10-30
MY179447A (en)	2020-11-06
BR112012001344B8 (pt)	2021-05-25
EP2432798B1 (de)	2013-04-03
JP2015178522A (ja)	2015-10-08
KR20160093110A (ko)	2016-08-05
JP2017105813A (ja)	2017-06-15
AR077491A1 (es)	2011-08-31
AU2010275849A1 (en)	2012-02-02
KR20120046182A (ko)	2012-05-09
PE20170084A1 (es)	2017-03-30
PT2623510T (pt)	2017-11-24
IL216967B (en)	2018-06-28
DK3252069T3 (da)	2019-06-24
TR201908600T4 (tr)	2019-07-22
HK1171456A1 (en)	2013-03-28
US10155004B2 (en)	2018-12-18
US8278469B2 (en)	2012-10-02
CA2768407C (en)	2017-10-24
EP3272763A1 (de)	2018-01-24
MX2012000930A (es)	2012-03-26
CO6491067A2 (es)	2012-07-31
PE20121085A1 (es)	2012-08-04
JP5795312B2 (ja)	2015-10-14
ECSP12011616A (es)	2012-02-29
CU24080B1 (pt)	2015-03-30
US20120149670A1 (en)	2012-06-14
ES2648292T3 (es)	2017-12-29
SG10201811830PA (en)	2019-02-27
LT2623510T (lt)	2017-12-11
EA201301263A1 (ru)	2014-08-29
PL3252069T3 (pl)	2019-09-30
ES2416461T3 (es)	2013-08-01
RS52811B (sr)	2013-10-31
JP2012533575A (ja)	2012-12-27
ZA201201222B (en)	2022-11-30

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BRPI0924622A2 (pt)	2016-03-01	composições para tratamento de tecidos, processo de fabricação, e método de uso.
IL216723A0 (en)	2012-03-01	1,2,4-thiazolidin-3-one derivatives and their use in the treatment of cancer
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