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BR0318640A - biaril sulfonamidas como inibidores da mmp - Google Patents

biaril sulfonamidas como inibidores da mmp

Info

Publication number
BR0318640A
BR0318640A BRPI0318640-7A BR0318640A BR0318640A BR 0318640 A BR0318640 A BR 0318640A BR 0318640 A BR0318640 A BR 0318640A BR 0318640 A BR0318640 A BR 0318640A
Authority
BR
Brazil
Prior art keywords
inhibitors
mmp
biaryl sulfonamides
biaryl
sulfonamides
Prior art date
Application number
BRPI0318640-7A
Other languages
English (en)
Inventor
Jeremy Ian Levin
Thomas Saltmarsh Rush
Frank Lovering
Yonghan Hu
Jianchang Li
Wei Li
Jun Ju Wu
Rajeev Hotchandani
Jason Shaoyun Xiang
Xuemei Du
Derek Cecil Cole
Steve Yikkai Tam
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0318640A publication Critical patent/BR0318640A/pt

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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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Abstract

"BIARIL SULFONAMIDAS COMO INIBIDORES DA MMP". A presente invenção refere-se às biaril sulfonamidas e seu uso como, por exemplo, inibidores da metaloproteinase.
BRPI0318640-7A 2003-12-04 2003-12-22 biaril sulfonamidas como inibidores da mmp BR0318640A (pt)

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PCT/US2003/040835 WO2005061477A1 (en) 2003-12-04 2003-12-22 Biaryl sulfonamides as mmp inhibitors

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US20080119513A1 (en) * 2004-09-06 2008-05-22 Fumihiko Watanabe Sulfonamide Derivative Selectively Inhibiting Mmp-13
JP2009505962A (ja) * 2005-07-29 2009-02-12 バイエル・ヘルスケア・エルエルシー 肥満を治療するためのビフェニルアミノ酸誘導体の製造および使用
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JP2014514259A (ja) * 2011-03-02 2014-06-19 アクイラス ファーマシューティカルズ， インコーポレイテッド 疼痛および他の障害の処置のための化合物および方法
KR20150000882A (ko) 2012-04-05 2015-01-05 씨에이치디아이 파운데이션, 인코포레이티드 키뉴레닌-3-모노산소첨가효소 억제제들, 약학 조성물들 및 이의 사용 방법
CN103333144B (zh) * 2013-06-17 2014-12-10 温州大学 一种2-硫基-3-卤代苯并呋喃化合物及其合成方法和用途
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KR20160066490A (ko) * 2014-12-02 2016-06-10 주식회사 씨앤드씨신약연구소 헤테로사이클 유도체 및 그의 용도
WO2017180723A1 (en) 2016-04-12 2017-10-19 Atrin Pharmaceuticals LLC Ataxia telengiectasia and rad3-related (atr) inhibitors and methods of their use
CN106905348B (zh) * 2017-02-13 2018-12-04 牡丹江医学院 一种预防和治疗急性肾损伤的药物及其制备方法和用途
CN112480020B (zh) * 2020-12-11 2023-10-10 东华理工大学 一种2-取代苯并恶唑化合物
CN113527152B (zh) * 2021-08-09 2023-07-28 西北农林科技大学 一种联苯磺酰胺类化合物及其防治农作物害虫的方法

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RU2006123559A (ru) 2008-01-10
KR20060093735A (ko) 2006-08-25
CA2548518A1 (en) 2005-07-07
ZA200604551B (en) 2008-11-26
AU2003299789A1 (en) 2005-07-14
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US20100137298A1 (en) 2010-06-03
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NO20062649L (no) 2006-09-01
ATE411306T1 (de) 2008-10-15
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CR8418A (es) 2007-08-28
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AU2004200247A1 (en) 2005-06-23
AR046859A1 (es) 2005-12-28
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