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BR0316865A - Variante de butirilcolinesterase, ácido nucleico, e, métodos para converter um derivado de camptotecina a um inibidor de topoisomerase, e para tratar câncer - Google Patents

Variante de butirilcolinesterase, ácido nucleico, e, métodos para converter um derivado de camptotecina a um inibidor de topoisomerase, e para tratar câncer

Info

Publication number
BR0316865A
BR0316865A BR0316865-4A BR0316865A BR0316865A BR 0316865 A BR0316865 A BR 0316865A BR 0316865 A BR0316865 A BR 0316865A BR 0316865 A BR0316865 A BR 0316865A
Authority
BR
Brazil
Prior art keywords
camptothecin derivative
topoisomerase inhibitor
converting
nucleic acid
variant
Prior art date
Application number
BR0316865-4A
Other languages
English (en)
Inventor
Jeffry D Watkins
James D Pancook
Original Assignee
Applied Molecular Evolution
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Molecular Evolution filed Critical Applied Molecular Evolution
Publication of BR0316865A publication Critical patent/BR0316865A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"VARIANTE DE BUTIRILCOLINESTERASE, áCIDO NUCLEICO, E, MéTODOS PAPA CONVERTER UM DERIVADO DE CAMPTOTECINA A UM IMBIDOR DE TOPOISOMERASE E PARA TRATAR CâNCER". A invenção proporciona uma variante de butirilquinesterase apresentando a seq³ência de aminoácidos selecionadas das SEQ ID NOS: 4, 6, 8, 10, 12, 14, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 69, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194 e 196, ou seu fragmento funcional. Adicionalmente, a invenção proporciona um método para converter um derivado de camptotecina a um inibidor de topoisomerase mediante o contato do derivado de camptotecina com uma variante de butirilcolinesterase selecionada das SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 1242 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 548, 150, 152, 154, 156, 1585 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, e 196, ou seu fragmento funcional, em condições que permitem conversão de um derivado de camptotecina a um inibidor de topoisomerase. Adicionalmente, a invenção proporciona um método para tratar câncer mediante a administração a um indivíduo de uma quantidade individual e efetiva de uma variante de butirilcolinesterase selecionada de SEQ ID NO 2, 4, 6, 8, 10, 12, 14, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, e 196, ou seu fragmento funcional, apresentando capacidade aumentada de converter um derivado de camptotecina a um inibidor de topoisomerase em comparação com butirilcolinesterase.
BR0316865-4A 2002-12-04 2003-12-04 Variante de butirilcolinesterase, ácido nucleico, e, métodos para converter um derivado de camptotecina a um inibidor de topoisomerase, e para tratar câncer BR0316865A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31066602A 2002-12-04 2002-12-04
PCT/US2003/038684 WO2004050041A2 (en) 2002-12-04 2003-12-04 Butyrylcholinesterase variants that alter the activity of chemotherapeutic agents

Publications (1)

Publication Number Publication Date
BR0316865A true BR0316865A (pt) 2005-10-25

Family

ID=32468084

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316865-4A BR0316865A (pt) 2002-12-04 2003-12-04 Variante de butirilcolinesterase, ácido nucleico, e, métodos para converter um derivado de camptotecina a um inibidor de topoisomerase, e para tratar câncer

Country Status (9)

Country Link
US (1) US20080213281A1 (pt)
EP (1) EP1581253A4 (pt)
JP (1) JP2006508665A (pt)
CN (1) CN100341568C (pt)
AU (1) AU2003298920A1 (pt)
BR (1) BR0316865A (pt)
CA (1) CA2507626A1 (pt)
MX (1) MXPA05005996A (pt)
WO (1) WO2004050041A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989261B2 (en) * 2001-12-20 2006-01-24 Eli Lilly And Company Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
AR044388A1 (es) * 2003-05-20 2005-09-07 Applied Molecular Evolution Moleculas de union a cd20
US20090208480A1 (en) * 2006-08-04 2009-08-20 Yue Huang Long half-life recombinant butyrylcholinesterase
US20100008978A1 (en) * 2008-05-09 2010-01-14 The Regents Of The University Of California Nanoparticles effective for internalization into cells
US20100009390A1 (en) * 2008-05-09 2010-01-14 The Regents Of The University Of California Mutant antibodies with high affinity for egfr
JP2011520447A (ja) * 2008-05-16 2011-07-21 ネクター セラピューティックス コリンエステラーゼ部分とポリマーとのコンジュゲート
CA2784861A1 (en) 2009-12-21 2011-07-14 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
CN103898101B (zh) * 2012-12-27 2017-08-08 上海桀蒙生物技术有限公司 利用转基因动物乳腺生物平台大规模生产重组人丁酰胆碱酯酶的方法
CN104630177A (zh) * 2013-11-08 2015-05-20 中国农业大学 一种利用人丁酰胆碱酯酶迷你基因在乳腺中表达重组人丁酰胆碱脂酶的方法
EP3137098A4 (en) 2014-04-29 2017-11-01 Mayo Foundation for Medical Education and Research Butyrylcholinesterases having an enhanced ability to hydrolyze acyl ghrelin
WO2018053216A1 (en) * 2016-09-15 2018-03-22 Mayo Foundation For Medical Education And Research Methods and materials for using butyrylcholinesterases to treat cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3015383B2 (ja) * 1987-09-11 2000-03-06 ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ 形質導入した線維芽およびそれらの使用
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5264563A (en) * 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
US5643578A (en) * 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
US5620896A (en) * 1992-03-23 1997-04-15 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US5506125A (en) * 1993-12-22 1996-04-09 Agracetus, Inc. Gene delivery instrument with replaceable cartridges
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5656465A (en) * 1994-05-04 1997-08-12 Therion Biologics Corporation Methods of in vivo gene delivery
US6001625A (en) * 1995-05-19 1999-12-14 The United States Of America As Represented By The Secretary Of The Army Site-directed mutagenesis of esterases
AU4529299A (en) * 1998-06-16 2000-01-05 Variagenics, Inc. Methods for treating a neurological disease by determining bche genotype
CN1331339A (zh) * 2000-06-26 2002-01-16 上海博德基因开发有限公司 一种新的多肽——人dna拓扑异构酶i11.44和编码这种多肽的多核苷酸
JP4252311B2 (ja) * 2000-12-26 2009-04-08 アプライド モレキュラー エボリューション，インコーポレイテッド 増大した触媒効率を有するブチリルコリンエステラーゼポリペプチド改変体およびその使用方法
US7070973B2 (en) * 2000-12-26 2006-07-04 Board Of Regents Of The University Of Nebraska Butyrylcholinesterase variants and methods of use
US20030153062A1 (en) * 2001-12-20 2003-08-14 Watkins Jeffry D. Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
US7049121B2 (en) * 2001-12-20 2006-05-23 Applied Molecular Evolution Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
US6989261B2 (en) * 2001-12-20 2006-01-24 Eli Lilly And Company Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use

Also Published As

Publication number Publication date
WO2004050041A2 (en) 2004-06-17
EP1581253A2 (en) 2005-10-05
US20080213281A1 (en) 2008-09-04
AU2003298920A1 (en) 2004-06-23
JP2006508665A (ja) 2006-03-16
MXPA05005996A (es) 2006-04-18
EP1581253A4 (en) 2007-02-14
CN1720063A (zh) 2006-01-11
WO2004050041A3 (en) 2004-10-28
CA2507626A1 (en) 2004-06-17
CN100341568C (zh) 2007-10-10

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 5A., 6A., E 7A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010.