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BR0316721A - Derivados de piridinalquil-aminoalquil-1h-indol tendo uma ação de inibição sobre 5-ht e a reabsorção da serotonina como antidepressivos e ansiolìticos - Google Patents

Derivados de piridinalquil-aminoalquil-1h-indol tendo uma ação de inibição sobre 5-ht e a reabsorção da serotonina como antidepressivos e ansiolìticos

Info

Publication number
BR0316721A
BR0316721A BR0316721-6A BR0316721A BR0316721A BR 0316721 A BR0316721 A BR 0316721A BR 0316721 A BR0316721 A BR 0316721A BR 0316721 A BR0316721 A BR 0316721A
Authority
BR
Brazil
Prior art keywords
anxiolytics
antidepressants
serotonin
indole derivatives
pyridinalkylaminoalkyl
Prior art date
Application number
BR0316721-6A
Other languages
English (en)
Inventor
Guenter Hoelzemann
Kai Schiemann
Timo Heinrich
Henning Boettcher
Joachim Leibrock
Christoph Van Amsterdam
Gerd Bartoszyk
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0316721A publication Critical patent/BR0316721A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

"DERIVADOS DE PIRIDINALQUIL-AMINOALQUIL-1H-INDOL TENDO UMA AçãO DE INIBIçãO SOBRE 5-HT E A REABSORçãO DA SEROTONINA COMO ANTIDEPRESSIVOS E ANSIOLìTICOS". A presente invenção refere-se a derivados de indol da fórmula I na qual X, Y, R¬ 1¬, R¬ 1¬', m e n tem os significados indicados na reivindicação de Patente 1, têm uma forte afinidade ao receptor 5-HT~ 1A~ e em alguns casos ao receptor 5-HT~ 1D~. OS COMPOSTOS inibem a reabsorção da serotonina, exibem propriedades agonísticas e antagonísticas da serotonina e são adequados como antidepressivos, ansiolíticos e para o tratamento de doenças neuro degenerativas.
BR0316721-6A 2002-11-22 2003-10-30 Derivados de piridinalquil-aminoalquil-1h-indol tendo uma ação de inibição sobre 5-ht e a reabsorção da serotonina como antidepressivos e ansiolìticos BR0316721A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10254596A DE10254596A1 (de) 2002-11-22 2002-11-22 Indolderivate
PCT/EP2003/012081 WO2004047840A1 (de) 2002-11-22 2003-10-30 Pyridinalykl-aminoalkyl-1h-indol derivate mit hemmender wirkung auf die 5-ht und serotonin wiederaufnahme als antidepressiva und anxiolytika

Publications (1)

Publication Number Publication Date
BR0316721A true BR0316721A (pt) 2005-10-18

Family

ID=32240308

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316721-6A BR0316721A (pt) 2002-11-22 2003-10-30 Derivados de piridinalquil-aminoalquil-1h-indol tendo uma ação de inibição sobre 5-ht e a reabsorção da serotonina como antidepressivos e ansiolìticos

Country Status (15)

Country Link
US (1) US7432282B2 (pt)
EP (1) EP1562596B1 (pt)
JP (1) JP4523416B2 (pt)
KR (1) KR20050085038A (pt)
CN (1) CN1708303A (pt)
AT (1) ATE337781T1 (pt)
AU (1) AU2003302361B2 (pt)
BR (1) BR0316721A (pt)
CA (1) CA2506960C (pt)
DE (2) DE10254596A1 (pt)
ES (1) ES2271697T3 (pt)
MX (1) MXPA05005278A (pt)
PL (1) PL375259A1 (pt)
WO (1) WO2004047840A1 (pt)
ZA (1) ZA200505037B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006267338B2 (en) * 2005-07-13 2012-08-16 Msd K.K. Heterocycle-substituted benzimidazole derivative
JP2009545522A (ja) 2006-06-22 2009-12-24 ラモット アット テル アビブ ユニバーシティ， リミテッド 末梢系限定的活性を有する薬としての新規なセロトニン再取り込み阻害剤
US9278947B2 (en) 2006-06-22 2016-03-08 Ramot At Tel-Aviv University Ltd. Serotonin reuptake inhibitors as drugs having peripheral-system-restricted activity
EP3083589B1 (en) * 2013-12-20 2019-12-18 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN112074505B (zh) 2018-03-08 2024-04-05 因赛特公司 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer
CN111689944B (zh) * 2020-06-10 2021-11-16 中山大学 喹啉色胺杂联体及其在制备治疗阿尔茨海默病的药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748182A (en) * 1986-03-05 1988-05-31 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
FR2614022B1 (fr) * 1987-04-15 1989-12-01 Roussel Uclaf Nouveaux derives 17-aza de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et ces compositions les renfermant
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
AU4355296A (en) * 1994-12-28 1996-07-19 Sankyo Company Limited Indole derivatives
US5942536A (en) * 1995-10-10 1999-08-24 Eli Lilly And Company N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists
CA2207137A1 (en) * 1996-06-14 1997-12-14 James Erwin Fritz Scavenger assisted combinatorial process for preparing libraries of secondary amine compounds
DE10029371A1 (de) * 2000-06-20 2002-01-03 Merck Patent Gmbh Heterocyclische Aminoalkylpyridinderivate als Psychopharmaka

Also Published As

Publication number Publication date
DE10254596A1 (de) 2004-06-03
CA2506960A1 (en) 2004-06-10
JP2006508991A (ja) 2006-03-16
ATE337781T1 (de) 2006-09-15
EP1562596A1 (de) 2005-08-17
WO2004047840A1 (de) 2004-06-10
AU2003302361B2 (en) 2009-06-18
US7432282B2 (en) 2008-10-07
JP4523416B2 (ja) 2010-08-11
ZA200505037B (en) 2006-11-29
CA2506960C (en) 2012-04-10
AU2003302361A1 (en) 2004-06-18
EP1562596B1 (de) 2006-08-30
MXPA05005278A (es) 2005-07-25
PL375259A1 (en) 2005-11-28
CN1708303A (zh) 2005-12-14
DE50304892D1 (de) 2006-10-12
ES2271697T3 (es) 2007-04-16
KR20050085038A (ko) 2005-08-29
US20060063811A1 (en) 2006-03-23

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]