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BR0212249A - Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, e, uso de um composto - Google Patents

Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, e, uso de um composto

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Publication number
BR0212249A
BR0212249A BR0212249-9A BR0212249A BR0212249A BR 0212249 A BR0212249 A BR 0212249A BR 0212249 A BR0212249 A BR 0212249A BR 0212249 A BR0212249 A BR 0212249A
Authority
BR
Brazil
Prior art keywords
compound
diseases
treatment
pharmaceutical composition
prophylaxis
Prior art date
Application number
BR0212249-9A
Other languages
English (en)
Inventor
Erik Rytter Ottosen
Anne Marie Horneman
Xifu Liang
Original Assignee
Leo Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma As filed Critical Leo Pharma As
Publication of BR0212249A publication Critical patent/BR0212249A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/44—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
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    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C309/63—Esters of sulfonic acids
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    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO DE TRATAMENTO OU PROFILAXIA DE DOENçAS, E, USO DE UM COMPOSTO". A invenção refere-se a uma nova classe de derivados de aminobenzofenonas, a preparações farmacêuticas compreendendo referidos compostos, a unidades de dosagem de preparações do referido tipo, a métodos de tratar pacientes compreendendo administrar referidos compostos, e ao uso de referidos compostos na fabricação de preparações farmacêuticas.
BR0212249-9A 2001-08-28 2002-08-26 Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, e, uso de um composto BR0212249A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31502501P 2001-08-28 2001-08-28
DKPA200200189 2002-02-08
PCT/DK2002/000557 WO2003018535A2 (en) 2001-08-28 2002-08-26 Novel aminobenzoephenones

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BR0212249A true BR0212249A (pt) 2004-10-05

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BR0212249-9A BR0212249A (pt) 2001-08-28 2002-08-26 Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, e, uso de um composto

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US (1) US7034015B2 (pt)
EP (1) EP1423356A2 (pt)
JP (2) JP4540984B2 (pt)
KR (1) KR100896667B1 (pt)
CN (1) CN100347151C (pt)
AU (1) AU2002331310B2 (pt)
BR (1) BR0212249A (pt)
CA (1) CA2458611C (pt)
HK (1) HK1068606A1 (pt)
HU (1) HUP0401644A3 (pt)
IL (2) IL160442A0 (pt)
MX (1) MXPA04001912A (pt)
PL (1) PL207487B1 (pt)
RU (1) RU2361855C2 (pt)
WO (1) WO2003018535A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7129229B2 (en) * 2000-08-11 2006-10-31 Nanogen Recognomics Gmbh Hydrazide building blocks and hydrazide modified biomolecules
CN100347151C (zh) * 2001-08-28 2007-11-07 利奥制药有限公司 新的氨基苯酰苯类化合物
AR042634A1 (es) * 2002-12-20 2005-06-29 Leo Pharma As Compuestos de aminobenzofenona
MXPA06000708A (es) * 2003-07-24 2006-04-19 Leo Pharma As Nuevos compuestos de aminobenzofenona.
WO2006063585A1 (en) 2004-12-13 2006-06-22 Leo Pharma A/S Triazole substituted aminobenzophenone compounds
DE102005022020A1 (de) * 2005-05-12 2006-11-23 Merckle Gmbh Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten
EP2206534A1 (de) 2008-10-09 2010-07-14 c-a-i-r biosciences GmbH Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
CA2774040C (en) * 2009-09-30 2014-09-09 Toray Industries, Inc. 2, 3-dihydro-1h-inden-2-yl urea derivatives and medical uses thereof
US9624215B2 (en) * 2012-10-31 2017-04-18 Toyama Chemical Co., Ltd. Amine derivative or salt thereof
US9758445B2 (en) * 2013-04-09 2017-09-12 Materia, Inc. Preparation of surfactants via cross-metathesis
WO2015126462A1 (en) * 2014-02-19 2015-08-27 Materia, Inc. Preparation of surfactants via cross-metathesis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57177058A (en) 1981-04-24 1982-10-30 Hodogaya Chem Co Ltd Novel fluoran compound
WO1997016442A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
GB9701453D0 (en) * 1997-01-24 1997-03-12 Leo Pharm Prod Ltd Aminobenzophenones
JPH11349568A (ja) * 1998-06-08 1999-12-21 Maruho Co Ltd ラクタム誘導体及びその医薬用途
HUP0201910A3 (en) 1999-07-16 2006-03-28 Leo Pharm Prod Ltd Novel aminobenzophenones, pharmaceutical compositions containing them and their use
ATE277891T1 (de) * 1999-07-16 2004-10-15 Leo Pharma As Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
CN1174956C (zh) 1999-07-16 2004-11-10 里奥药物制品有限公司 作为IL-1β和TNF-α的抑制剂的氨基二苯酮
RU2240995C2 (ru) * 1999-07-16 2004-11-27 Лео Фармасьютикал Продактс Лтд.А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) Аминобензофеноны в качестве ингибиторов интерлейкина il-1бета и фактора некроза опухолей tnf-альфа
EP1210325B1 (en) * 1999-07-16 2004-10-06 Leo Pharma A/S Aminobenzophenones as inhibitors of il-1beta and tnf-alpha
EP1237845B1 (en) * 1999-12-06 2007-05-23 Leo Pharma A/S Aminobenzophenones as inhibitors of il-1beta and tnf-alpha
EP1289958A2 (en) * 2000-05-22 2003-03-12 Leo Pharma A/S BENZOPHENONES AS INHIBITORS OF IL-1$g(b) AND TNF-$g(a)
US20020165286A1 (en) * 2000-12-08 2002-11-07 Hanne Hedeman Dermal anti-inflammatory composition
CN100347151C (zh) * 2001-08-28 2007-11-07 利奥制药有限公司 新的氨基苯酰苯类化合物

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KR20040029455A (ko) 2004-04-06
HUP0401644A3 (en) 2008-03-28
JP4540984B2 (ja) 2010-09-08
AU2002331310B2 (en) 2008-07-17
CN1561327A (zh) 2005-01-05
KR100896667B1 (ko) 2009-05-14
US20030119902A1 (en) 2003-06-26
JP2005500400A (ja) 2005-01-06
CN100347151C (zh) 2007-11-07
HK1068606A1 (en) 2005-04-29
IL160442A (en) 2011-11-30
EP1423356A2 (en) 2004-06-02
IL160442A0 (en) 2004-07-25
US7034015B2 (en) 2006-04-25
PL368686A1 (en) 2005-04-04
MXPA04001912A (es) 2004-07-23
PL207487B1 (pl) 2010-12-31
RU2004109142A (ru) 2005-08-20
CA2458611A1 (en) 2003-03-06
CA2458611C (en) 2012-05-29
RU2361855C2 (ru) 2009-07-20
JP2010189410A (ja) 2010-09-02
HUP0401644A2 (hu) 2004-11-29
WO2003018535A3 (en) 2004-03-18
WO2003018535A2 (en) 2003-03-06

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