BR0207310A - Composição farmacêutica de interferon gama ou de pirfenidona com diagnósticos moleculares para o melhor tratamento de doenças pulmonares intersticiais - Google Patents
Composição farmacêutica de interferon gama ou de pirfenidona com diagnósticos moleculares para o melhor tratamento de doenças pulmonares intersticiaisInfo
- Publication number
- BR0207310A BR0207310A BR0207310-2A BR0207310A BR0207310A BR 0207310 A BR0207310 A BR 0207310A BR 0207310 A BR0207310 A BR 0207310A BR 0207310 A BR0207310 A BR 0207310A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- interstitial lung
- pirfenidone
- molecular diagnostics
- interferon gamma
- Prior art date
Links
- 208000029523 Interstitial Lung disease Diseases 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003073 pirfenidone Drugs 0.000 title abstract 2
- 102000008070 Interferon-gamma Human genes 0.000 title 1
- 108010074328 Interferon-gamma Proteins 0.000 title 1
- 229960003130 interferon gamma Drugs 0.000 title 1
- 208000019693 Lung disease Diseases 0.000 abstract 2
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 238000011281 clinical therapy Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA DE INTERFERON GAMA OU DE PIRFENIDONA COM DIAGNóSTICOS MOLECULARES PARA O MELHOR TRATAMENTO DE DOENçAS PULMONARES INTERSTICIAIS". A presente invenção refere-se a uma nova composição farmacêutica que compreende interferon-<sym> ou pirfenidona e um arranjo para diagnóstico de polinucleotídeos candidatos para o tratamento melhorado de doenças pulmonares, especialmente para todas as formas de doenças pulmonares intersticiais. Essa invenção descreve a combinação de diagnósticos moleculares e de terapia clínica como um novo princípio de medicação para a redução da mortalidade e melhoria do controle da doença em doenças pulmonares intersticiais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01130011 | 2001-12-18 | ||
PCT/CH2002/000691 WO2003051388A2 (en) | 2001-12-18 | 2002-12-12 | Pharmaceutical composition of interferon gamma or pirfenidone with molecular diagnostics for the improved treatment of interstitial lung diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0207310A true BR0207310A (pt) | 2004-08-17 |
Family
ID=8179579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0207310-2A BR0207310A (pt) | 2001-12-18 | 2002-12-12 | Composição farmacêutica de interferon gama ou de pirfenidona com diagnósticos moleculares para o melhor tratamento de doenças pulmonares intersticiais |
Country Status (9)
Country | Link |
---|---|
US (2) | US20060270618A1 (pt) |
EP (1) | EP1455813B1 (pt) |
JP (1) | JP2005528082A (pt) |
CN (1) | CN1620309A (pt) |
AU (1) | AU2002347182A1 (pt) |
BR (1) | BR0207310A (pt) |
CA (1) | CA2470763A1 (pt) |
NO (1) | NO20033642L (pt) |
WO (1) | WO2003051388A2 (pt) |
Families Citing this family (48)
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US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
BR0207310A (pt) * | 2001-12-18 | 2004-08-17 | Mondobiotech Sa | Composição farmacêutica de interferon gama ou de pirfenidona com diagnósticos moleculares para o melhor tratamento de doenças pulmonares intersticiais |
EP1551369A4 (en) * | 2002-08-28 | 2007-05-09 | Intermune Inc | COMBINATION THERAPY FOR THE TREATMENT OF FIBROTIC DISEASES |
EP1644028B1 (de) * | 2003-07-14 | 2009-05-27 | mondoBIOTECH AG | Substanzen mit biologischer aktivität des vasoaktiven intestinalen peptids für die behandlung von interstitiellen lungenerkrankungen |
PT1926813T (pt) * | 2005-09-23 | 2016-09-06 | Consejo Superior Investigacion | Populações de células que têm atividade imunorreguladora, método para isolamento e usos |
CA2634357A1 (en) | 2005-12-21 | 2007-06-28 | Basf Se | Pharmaceutical formulation for producing rapidly disintegrating tablets |
CN101631877A (zh) * | 2007-01-09 | 2010-01-20 | 百时美施贵宝公司 | 用于预测可与前列腺细胞中蛋白酪氨酸激酶和/或蛋白酪氨酸激酶途径相互作用和/或对其进行调节的化合物的活性的多核苷酸的鉴定 |
MX2009013063A (es) | 2007-06-06 | 2010-01-15 | Basf Se | Formulacion farmaceutica para la produccion de tabletas de desintegracion rapida. |
DK2170828T3 (da) * | 2007-06-20 | 2013-03-04 | Auspex Pharmaceuticals Inc | Substituerede n-aryl pyridinoner som fibrotiske inhibitorer |
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CA2747251A1 (en) * | 2009-01-26 | 2010-07-29 | Intermune, Inc. | Methods for treating acute myocardial infarctions and associated disorders |
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CA2771774A1 (en) * | 2009-08-21 | 2011-02-24 | Gilead Biologics, Inc. | In vitro screening assays |
CA2771630A1 (en) * | 2009-08-21 | 2011-02-24 | Victoria Smith | Therapeutic methods and compositions |
EP2467396A4 (en) * | 2009-08-21 | 2012-12-26 | Gilead Biologics Inc | CATALYTIC DOMAINS FROM LYSYL OXIDASE AND LOXL2 |
WO2011022670A1 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
CN102711839A (zh) * | 2009-08-21 | 2012-10-03 | 吉联亚生物科技有限公司 | 体内筛选试验 |
US20120329666A1 (en) * | 2009-10-05 | 2012-12-27 | Duke University | Peripheral Blood Biomarkers for Idiopathic Interstitial Pneumonia and Methods of Use |
RU2015108348A (ru) | 2010-02-04 | 2015-07-20 | Джилид Байолоджикс, Инк. | Антитела, связывающиеся с лизилоксидазоподобным ферментом-2 (loxl2), и способы их применения |
AU2011267089B2 (en) | 2010-06-14 | 2017-02-16 | Lykera Biomed Sa | S100A4 antibodies and therapeutic uses thereof |
US10092552B2 (en) | 2011-01-31 | 2018-10-09 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
WO2014145050A1 (en) | 2013-03-15 | 2014-09-18 | Atyr Pharma, Inc. | Histidyl-trna synthetase-fc conjugates |
CN103467612B (zh) * | 2013-09-09 | 2015-06-24 | 山东省农业科学院农产品研究所 | 一种从热榨花生粕中同步提取多糖和蛋白的方法 |
NZ722927A (en) | 2014-01-10 | 2022-07-29 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
GB201408100D0 (en) * | 2014-05-07 | 2014-06-18 | Sec Dep For Health The | Detection method |
JOP20200115A1 (ar) * | 2014-10-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات)) |
EP3215170A4 (en) * | 2014-11-05 | 2018-04-25 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
EP3344283A1 (en) * | 2015-08-31 | 2018-07-11 | Merck Patent GmbH | Methods for the modulation of lgals3bp to treat systemic lupus erythematosus |
CN107356761B (zh) * | 2016-05-09 | 2020-03-31 | 上海华盈生物医药科技有限公司 | 接骨木凝集素及结合珠蛋白相关蛋白的用途 |
ES2912266T3 (es) | 2016-12-23 | 2022-05-25 | Immunogen Inc | Inmunoconjugados dirigidos a ADAM9 y procedimientos de uso de los mismos |
WO2018119166A1 (en) | 2016-12-23 | 2018-06-28 | Macrogenics, Inc. | Adam9-binding molecules, and methods of use thereof |
CN106860855B (zh) * | 2017-03-01 | 2021-06-11 | 成都惠泰生物医药有限公司 | 多肽及多肽衍生物在预防和治疗纤维化疾病中的应用 |
KR102368159B1 (ko) | 2017-03-01 | 2022-03-03 | 청두 후타이 바이오메디슨 컴퍼니 리미티드 | 폴리펩티드, 폴리펩티드 단편, 그의 유도체, 및 그의 적용 |
CN109384830B (zh) * | 2017-08-09 | 2021-12-03 | 成都惠泰生物医药有限公司 | 多肽、多肽片段及其衍生物在防治纤维化疾病中的应用 |
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CN109722455B (zh) * | 2017-10-31 | 2022-03-11 | 中国科学院天津工业生物技术研究所 | 微生物发酵生产谷内酯的方法、工程菌及应用 |
AU2019294510A1 (en) | 2018-06-26 | 2021-01-21 | Immunogen, Inc. | Immunoconjugates targeting ADAM9 and methods of use thereof |
CN111103426B (zh) * | 2019-12-19 | 2022-10-21 | 广州市妇女儿童医疗中心 | Lap3作为儿童腺病毒肺炎诊断标志物的应用 |
CN113846150B (zh) * | 2020-06-28 | 2024-07-26 | 深圳华大生命科学研究院 | 核酸分子及其应用 |
WO2022192134A1 (en) | 2021-03-08 | 2022-09-15 | Immunogen, Inc. | Methods for increasing efficacy of immunoconjugates targeting adam9 for the treatment of cancer |
CN114276418B (zh) * | 2021-12-28 | 2024-06-25 | 中国科学技术大学 | 一种可用于调控微管、治疗脱髓鞘病变靶向治疗的rna |
CN114452376A (zh) * | 2022-01-21 | 2022-05-10 | 上海市精神卫生中心(上海市心理咨询培训中心) | 胰岛素样生长因子结合蛋白2在制备治疗神经脱髓鞘性疾病的药物中的应用 |
CN114636825B (zh) * | 2022-03-02 | 2022-12-20 | 中国医学科学院北京协和医院 | Golm1作为肺纤维化生物标记物、靶点的应用及检测Golm1的试剂的应用 |
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IE873041L (en) * | 1987-11-11 | 1989-05-11 | Ailbe Brennan | Viral antigens, diagnostic assay therefor and vaccines¹containing them |
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JP4503844B2 (ja) * | 1998-09-24 | 2010-07-14 | イノジェネティックス・ナムローゼ・フェンノートシャップ | 急性気道感染(ari)を引き起こす微生物の同定 |
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EP1227831A2 (en) * | 1999-11-10 | 2002-08-07 | Mondobiotech SA | Interferon gamma for the treatment of asthma |
EP1231943A1 (en) * | 1999-11-12 | 2002-08-21 | Maxygen Holdings Ltd | Interferon gamma conjugates |
BR0207310A (pt) * | 2001-12-18 | 2004-08-17 | Mondobiotech Sa | Composição farmacêutica de interferon gama ou de pirfenidona com diagnósticos moleculares para o melhor tratamento de doenças pulmonares intersticiais |
-
2002
- 2002-12-12 BR BR0207310-2A patent/BR0207310A/pt not_active Application Discontinuation
- 2002-12-12 AU AU2002347182A patent/AU2002347182A1/en not_active Abandoned
- 2002-12-12 JP JP2003552321A patent/JP2005528082A/ja active Pending
- 2002-12-12 WO PCT/CH2002/000691 patent/WO2003051388A2/en active Application Filing
- 2002-12-12 CN CNA02828206XA patent/CN1620309A/zh active Pending
- 2002-12-12 US US10/498,079 patent/US20060270618A1/en not_active Abandoned
- 2002-12-12 CA CA002470763A patent/CA2470763A1/en not_active Abandoned
- 2002-12-12 EP EP02782602.3A patent/EP1455813B1/en not_active Expired - Lifetime
-
2003
- 2003-08-15 NO NO20033642A patent/NO20033642L/no not_active Application Discontinuation
-
2008
- 2008-04-25 US US12/110,151 patent/US20090142301A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2002347182A1 (en) | 2003-06-30 |
CA2470763A1 (en) | 2003-06-26 |
US20090142301A1 (en) | 2009-06-04 |
EP1455813A2 (en) | 2004-09-15 |
NO20033642D0 (no) | 2003-08-15 |
WO2003051388A3 (en) | 2003-10-30 |
US20060270618A1 (en) | 2006-11-30 |
EP1455813B1 (en) | 2015-07-15 |
NO20033642L (no) | 2003-10-17 |
JP2005528082A (ja) | 2005-09-22 |
CN1620309A (zh) | 2005-05-25 |
WO2003051388A2 (en) | 2003-06-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved | ||
B25A | Requested transfer of rights approved |
Owner name: MONDOBIOTECH LABORATORIES ANSTALT (LI) Free format text: TRANSFERIDO DE: MONDOBIOTECH INTERFERON SA |
|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |