BR0206206A - Derivados de etoposide e análogos, e composições farmacêuticas contendo os mesmos - Google Patents
Derivados de etoposide e análogos, e composições farmacêuticas contendo os mesmosInfo
- Publication number
- BR0206206A BR0206206A BR0206206-2A BR0206206A BR0206206A BR 0206206 A BR0206206 A BR 0206206A BR 0206206 A BR0206206 A BR 0206206A BR 0206206 A BR0206206 A BR 0206206A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- pharmaceutical compositions
- analogs
- compositions containing
- derivatives
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- -1 R represents H Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical class COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/033—Uronic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
"DERIVADOS DE ETOPOSIDE E ANáLOGOS, E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS". A invenção se refere a compostos tendo a seguinte fórmula (1), em que: R~ a~ representa uma metade açúcar, um grupo arilamino, ou um grupo alquil compreendendo pelo menos um grupo amino, R~ b~ representa um átomo de halogênio, um grupo halogenoalquil, um grupo nitro, ou um grupo -NR(COR<39>) em que R e R<39>, independentemente de cada outro, representam um grupo alquil, R, representa H, ou um grupo de proteção para o grupo COOH, R~ 2~, R~ 3~, e R~ 4~, independentemente de cada outro, representam H, ou um grupo de proteção para o grupo OH. A invenção também se refere ao uso de tais compostos em composições farmacêuticas para o tratamento de câncer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01402787 | 2001-10-26 | ||
| PCT/EP2002/011965 WO2003035661A1 (en) | 2001-10-26 | 2002-10-25 | Derivatives of etoposide and analogs, and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0206206A true BR0206206A (pt) | 2005-01-11 |
Family
ID=8182942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0206206-2A BR0206206A (pt) | 2001-10-26 | 2002-10-25 | Derivados de etoposide e análogos, e composições farmacêuticas contendo os mesmos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050009759A1 (pt) |
| EP (1) | EP1438319A1 (pt) |
| JP (1) | JP2005511550A (pt) |
| AP (1) | AP2003002831A0 (pt) |
| BR (1) | BR0206206A (pt) |
| CA (1) | CA2464311A1 (pt) |
| NO (1) | NO20032959L (pt) |
| WO (1) | WO2003035661A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017374B2 (en) | 2004-12-02 | 2011-09-13 | Council Of Scientific And Industrial Research | Processes for decolorization of colored effluents |
| CN102144163A (zh) | 2008-04-10 | 2011-08-03 | 麻省理工学院 | 关于鉴定和使用靶向癌症干细胞的试剂的方法 |
| US10106778B2 (en) | 2012-11-08 | 2018-10-23 | Whitehead Institute For Biomedical Research | Selective targeting of cancer stem cells |
| WO2014183055A1 (en) | 2013-05-10 | 2014-11-13 | M. Alphabet 2, L.L.C. | Methods of treating skin conditions using cyclolignan compounds |
| US10398672B2 (en) | 2014-04-29 | 2019-09-03 | Whitehead Institute For Biomedical Research | Methods and compositions for targeting cancer stem cells |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904768A (en) * | 1987-08-04 | 1990-02-27 | Bristol-Myers Company | Epipodophyllotoxin glucoside 4'-phosphate derivatives |
| DE3935016A1 (de) * | 1989-10-20 | 1991-04-25 | Behringwerke Ag | Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten |
| TWI307341B (en) * | 2002-10-11 | 2009-03-11 | Plantaceutica Inc | Anticancer compounds |
-
2002
- 2002-10-25 BR BR0206206-2A patent/BR0206206A/pt not_active Application Discontinuation
- 2002-10-25 EP EP20020781289 patent/EP1438319A1/en not_active Withdrawn
- 2002-10-25 WO PCT/EP2002/011965 patent/WO2003035661A1/en not_active Application Discontinuation
- 2002-10-25 US US10/493,597 patent/US20050009759A1/en not_active Abandoned
- 2002-10-25 CA CA002464311A patent/CA2464311A1/en not_active Abandoned
- 2002-10-25 JP JP2003538174A patent/JP2005511550A/ja active Pending
- 2002-10-25 AP APAP/P/2003/002831A patent/AP2003002831A0/en unknown
-
2003
- 2003-06-26 NO NO20032959A patent/NO20032959L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20032959L (no) | 2003-08-25 |
| WO2003035661A1 (en) | 2003-05-01 |
| US20050009759A1 (en) | 2005-01-13 |
| EP1438319A1 (en) | 2004-07-21 |
| AP2003002831A0 (en) | 2003-09-30 |
| CA2464311A1 (en) | 2003-05-01 |
| JP2005511550A (ja) | 2005-04-28 |
| NO20032959D0 (no) | 2003-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |