[go: up one dir, main page]

BR0016955A - Derivados inovadores de indoles, seus compostos, sua composição farmacêutica seu uso e método de administração - Google Patents

Derivados inovadores de indoles, seus compostos, sua composição farmacêutica seu uso e método de administração

Info

Publication number
BR0016955A
BR0016955A BR0016955-2A BR0016955A BR0016955A BR 0016955 A BR0016955 A BR 0016955A BR 0016955 A BR0016955 A BR 0016955A BR 0016955 A BR0016955 A BR 0016955A
Authority
BR
Brazil
Prior art keywords
compounds
innovative
administration
pharmaceutical composition
indole derivatives
Prior art date
Application number
BR0016955-2A
Other languages
English (en)
Inventor
Thomas Ruhland
Ejner Knud Moltzen
Christian Krog-Jensen
Kim Andersen
Mario Rottlander
Gitte Mikkelsen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR0016955A publication Critical patent/BR0016955A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"DERIVADOS INOVADORES DE INDOLES SEUS COMPOSTOS SUA COMPOSIçãO FARMACêUTICA SEU USO E MéTODO DE ADMINISTRAçãO". A invenção provê compostos da fórmula (I) onde X representa O ou S; n é 2, 3, 4, 5, 6, 7, 8, 9, ou 1 0; m é 2 ou 3; Y representa N, C ou CH; e a linha pontilhada 2 3 4 5 6 7 8 representa uma união opcional; R^ 1^, R^ 1'^, R^ 2^, R^ 3^, R^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 8^, R^ 9^, R^ 10^, R^ 11^, e R^ 12^, São como definidos na descrição. Os compostos são ligandos do receptor 5-HT~ 1a~.
BR0016955-2A 1999-12-30 2000-12-29 Derivados inovadores de indoles, seus compostos, sua composição farmacêutica seu uso e método de administração BR0016955A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199901889 1999-12-30
PCT/DK2000/000742 WO2001049680A1 (en) 1999-12-30 2000-12-29 Novel indole derivatives

Publications (1)

Publication Number Publication Date
BR0016955A true BR0016955A (pt) 2003-04-29

Family

ID=8108836

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016955-2A BR0016955A (pt) 1999-12-30 2000-12-29 Derivados inovadores de indoles, seus compostos, sua composição farmacêutica seu uso e método de administração

Country Status (23)

Country Link
US (1) US20030050307A1 (pt)
EP (1) EP1246818A1 (pt)
JP (1) JP2003519226A (pt)
KR (1) KR20020063288A (pt)
CN (1) CN1437598A (pt)
AR (1) AR027134A1 (pt)
AU (1) AU2352101A (pt)
BG (1) BG106937A (pt)
BR (1) BR0016955A (pt)
CA (1) CA2395606A1 (pt)
CZ (1) CZ20022489A3 (pt)
EA (1) EA200200727A1 (pt)
HU (1) HUP0203767A3 (pt)
IL (1) IL150336A0 (pt)
IS (1) IS6434A (pt)
MX (1) MXPA02006498A (pt)
NO (1) NO20023148D0 (pt)
NZ (1) NZ519648A (pt)
PL (1) PL355538A1 (pt)
SK (1) SK9452002A3 (pt)
TR (1) TR200201689T2 (pt)
WO (1) WO2001049680A1 (pt)
ZA (1) ZA200204969B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002048105A2 (en) 2000-11-16 2002-06-20 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
NZ529461A (en) * 2001-06-29 2005-09-30 H Novel indole derivatives
ES2326078T3 (es) 2002-08-22 2009-09-30 Dainippon Sumitomo Pharma Co., Ltd. Medicamento destinado al sindrome de la disfuncion de integracion.
JP4624261B2 (ja) * 2003-06-23 2011-02-02 大日本住友製薬株式会社 老人性痴呆症治療剤
US20070160537A1 (en) 2004-02-20 2007-07-12 Takeo Ishiyama In vivo screening method of therapeutic agent for memory/learning dysfunctions by schizophrenia
AR055203A1 (es) * 2005-08-31 2007-08-08 Otsuka Pharma Co Ltd Derivados de benzotiofeno con propiedades antipsicoticas
JP4785881B2 (ja) * 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
US8258139B2 (en) 2010-11-08 2012-09-04 Dainippon Sumitomo Pharma Co., Ltd. Method of treatment for mental disorders
PL395469A1 (pl) * 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego
CN116554145A (zh) * 2022-01-29 2023-08-08 江苏恩华药业股份有限公司 芳烷基-4-(1h)吲哚基哌嗪衍生物、其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567884B1 (fr) * 1984-07-19 1987-03-06 Roussel Uclaf Nouveaux derives de l'indole, leur preparation, leur application comme medicaments et les compositions les renfermant
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
JP2002513001A (ja) * 1998-04-29 2002-05-08 アメリカン・ホーム・プロダクツ・コーポレイション 抗精神病性のインドリル誘導体

Also Published As

Publication number Publication date
WO2001049680A1 (en) 2001-07-12
AR027134A1 (es) 2003-03-12
EA200200727A1 (ru) 2002-12-26
TR200201689T2 (tr) 2002-10-21
SK9452002A3 (en) 2002-11-06
PL355538A1 (en) 2004-05-04
HUP0203767A2 (hu) 2003-03-28
NO20023148L (no) 2002-06-28
BG106937A (en) 2003-04-30
HUP0203767A3 (en) 2004-06-28
IS6434A (is) 2002-06-19
CN1437598A (zh) 2003-08-20
IL150336A0 (en) 2002-12-01
CA2395606A1 (en) 2001-07-12
KR20020063288A (ko) 2002-08-01
ZA200204969B (en) 2003-09-22
NO20023148D0 (no) 2002-06-28
US20030050307A1 (en) 2003-03-13
EP1246818A1 (en) 2002-10-09
CZ20022489A3 (cs) 2002-10-16
NZ519648A (en) 2004-05-28
JP2003519226A (ja) 2003-06-17
MXPA02006498A (es) 2002-11-29
AU2352101A (en) 2001-07-16

Similar Documents

Publication Publication Date Title
FI980341A (fi) 2-oksi-indolijohdannaisia
LU90283I2 (fr) Sporanox soluté buvable et ses dérivés pharmaceutiquement acceptables
UY24555A1 (es) Nuevos compuestos
BR0016955A (pt) Derivados inovadores de indoles, seus compostos, sua composição farmacêutica seu uso e método de administração
SE8804629D0 (sv) New therapeutically active compounds
NO20015379D0 (no) Indolinderivater som progesteronantagonister
DE69217224D1 (de) Substituierte indole als anti-aids pharmaceutische zubereitungen
BR9811557A (pt) Derivados do 2-)4-aril ou heteroaril-piperazin-1-ilmetil)-1h-indol
PT1007523E (pt) Derivados indole e 2,3-di-ridroindole, sua preparacao e utilizacao
EA200100774A1 (ru) Гетероциклические производные с функциональными группами (варианты), фармацевтическая композиция и комбинация, способ модулирования активности рецептора хемокина (варианты), способ профилактики инфицирования вич и лечения инфекции вич, замедления проявления спид и лечения спид, способ лечения воспалительных процессов
PT1254134E (pt) Derivados de 1,3-di-hidro-2h-indol-2-ona e sua utilizacao como ligandos para os receptores v1b ou v1b e v1a da arginina-vasopressina
DE60001586D1 (de) Diphenyl-piperidin derivate
ES2180573T3 (es) Uso de derivados de indol como antagonistas de 5ht1.
HUP9801950A2 (hu) 2-(Aril-fenil-amino)-imidazolin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
ATE384708T1 (de) Piperazinderivate als aktivitätsmodulatoren der chemokinrezeptoren
NO963331L (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
BR9811483A (pt) Derivados do ácido amino-etil-fenóxi-acético e fármacos para a remissão da dor e promover a remoção de cálculos na litìase urinária
DZ2362A1 (fr) Compositions pharmaceutiques contenant des dérivésde n-sulfonyl indoline
DE60010855D1 (de) Phenylsulphonylderivative als 5-ht rezeptorliganden
BR9911843A (pt) 4 5 6 7-indol e derivados de indolina, preparação e utilização dos mesmos
ATE217619T1 (de) Endothelin-rezeptor-antagonisten
BR9914397A (pt) Derivados da ureidopiperidina como antagonistas seletivos dos receptores nk3 humanos
AU7575187A (en) New tetracyclic indole derivatives
BRPI0409317A (pt) derivado de indol ou indolina substituìdo, composição farmacêutica, e, uso da mesma
BR9810790A (pt) Indol e derivados de 2, 3 diidroindol, preparação e utilização dos mesmos

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1929 DE 26/12/2007.