BR0010680A - Agentes antiinfecciosos de macrolìdeo - Google Patents
Agentes antiinfecciosos de macrolìdeoInfo
- Publication number
- BR0010680A BR0010680A BR0010680-1A BR0010680A BR0010680A BR 0010680 A BR0010680 A BR 0010680A BR 0010680 A BR0010680 A BR 0010680A BR 0010680 A BR0010680 A BR 0010680A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- amino
- methylene
- Prior art date
Links
- 230000002924 anti-infective effect Effects 0.000 title abstract 2
- 229940041033 macrolides Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000005015 aryl alkynyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012678 infectious agent Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção "AGENTES ANTIINFECCIOSOS DE MACROLìDEO". Compostos de fórmula (1), (2) ou (3), nas quais R~ a~ é H; (1 - 10C) alquila substituída ou não substituída; (2 - 10C) alquenila substituída ou não substituída; (2 - 10C) alquinila substituída ou não substituída; (4 - 14C) arila substituída ou não substituída; (5 - 20C) arilalquila substituída ou não substituída; ou OR~ a~ é substituído por H; R~ b~ é H ou halogênio; R~ e~ é H ou um grupo de proteção; R~ d~ é metila, (3 - 10C) alquila não substituída; (1 - 10C) alquila substituída; (2 - 10C) alquinila substituída ou não substituída; (4 - 14C) arila substituída ou não substituída; (5 - 20C) arilalquila substituída ou não substituída; (5 - 20C) arilalquenila substituída ou não substituída; (5 - 20C) arilalquinila substituída ou não substituída; (5 - 20C) amidoarilalquila substituída ou não substituída; (5 - 20C) amidoarilalquenila substituída ou não substituída; ou (5 - 20C) amidoarilalquinila substituída ou não substituída; R~ e~ é H ou um grupo de proteção; L é metileno ou carbonila; T é -O-, -N(R)-, -N(OR)-, -N(NHCOR)-, -N(N=CHR)-, ou -N(NHR)- onde R é H ou R~ a~ como acima definido, com a condição de que quando L for metileno, T seja -O-; um dentre Z e Y é H e o outro é OH, OH protegido, ou amino, mono- ou dialquilamino, amino protegido, ou um heterociclo de amino ou Z e Y juntos são =O, =NOH ou uma oxima derivatizada; incluindo quaisquer sais farmaceuticamente aceitáveis destes e quaisquer formas estereoisoméricas e misturas de formas estereoisoméricas destes, são agentes antimicrobianos.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12972999P | 1999-04-16 | 1999-04-16 | |
| US14017599P | 1999-06-18 | 1999-06-18 | |
| US17215499P | 1999-12-17 | 1999-12-17 | |
| US17215999P | 1999-12-17 | 1999-12-17 | |
| US17380599P | 1999-12-30 | 1999-12-30 | |
| US17380499P | 1999-12-30 | 1999-12-30 | |
| US09/550,045 US6395710B1 (en) | 1999-04-16 | 2000-04-14 | Macrolide antiinfective agents |
| PCT/US2000/009914 WO2000063224A2 (en) | 1999-04-16 | 2000-04-14 | Macrolide antiinfective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0010680A true BR0010680A (pt) | 2002-02-19 |
Family
ID=27568857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0010680-1A BR0010680A (pt) | 1999-04-16 | 2000-04-14 | Agentes antiinfecciosos de macrolìdeo |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6395710B1 (pt) |
| EP (1) | EP1171446B1 (pt) |
| JP (1) | JP2003523938A (pt) |
| KR (2) | KR20020007374A (pt) |
| CN (1) | CN1241931C (pt) |
| AT (1) | ATE340183T1 (pt) |
| AU (2) | AU773678B2 (pt) |
| BR (1) | BR0010680A (pt) |
| CA (1) | CA2369816A1 (pt) |
| DE (1) | DE60030847T2 (pt) |
| ES (1) | ES2272273T3 (pt) |
| ID (1) | ID30547A (pt) |
| IL (2) | IL145777A0 (pt) |
| MX (1) | MXPA01010524A (pt) |
| NZ (1) | NZ515027A (pt) |
| WO (2) | WO2000063225A2 (pt) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| IL144178A0 (en) | 1999-01-27 | 2002-05-23 | Pfizer Prod Inc | Ketolide antibiotics |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6590083B1 (en) * | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| PT1167376E (pt) | 2000-06-30 | 2004-09-30 | Pfizer Prod Inc | Antibioticos macrolidos |
| US6472372B1 (en) | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
| KR100904941B1 (ko) * | 2001-03-21 | 2009-06-29 | 다우 아그로사이언시즈 엘엘씨 | 살충성 스피노신 유도체 |
| EP1430068A1 (en) | 2001-09-17 | 2004-06-23 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-carbamate-11,12-lacto-ketolide antimicrobials |
| US6825170B2 (en) | 2001-12-05 | 2004-11-30 | Ortho-Mcneil Pharmaceutical, Inc. | 6-O-acyl ketolide antibacterials |
| US8063021B2 (en) * | 2002-01-17 | 2011-11-22 | Kosan Biosciences Incorporated | Ketolide anti-infective compounds |
| DK1483251T3 (da) | 2002-03-12 | 2010-04-12 | Bristol Myers Squibb Co | C3-cyano-epothilon-derivater |
| US20040014691A1 (en) * | 2002-04-25 | 2004-01-22 | Searle Xenia Beebe | 9-Oxime macrolide antibacterials |
| US20040009932A1 (en) * | 2002-04-26 | 2004-01-15 | Kathleen Phelan | Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae |
| WO2003102010A1 (en) | 2002-05-31 | 2003-12-11 | Janssen Pharmaceutica N.V. | 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents |
| US7427493B2 (en) | 2002-06-28 | 2008-09-23 | Kosan Biosciences Incorporated | Recombinant genes for polyketide modifying enzymes |
| US6946482B2 (en) * | 2002-08-29 | 2005-09-20 | Kosan Biosciences, Inc. | Motilide compounds |
| CA2529817C (en) * | 2003-03-10 | 2013-02-12 | Optimer Pharmaceuticals, Inc. | Novel antibacterial agents |
| US20050113319A1 (en) * | 2003-08-26 | 2005-05-26 | Christopher Carreras | 11-Deoxy-6,9-ether erythromycin compounds |
| US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
| AU2003304705A1 (en) * | 2003-12-24 | 2005-08-03 | Enanta Pharmaceuticals, Inc. | 11-csubsituted erythromycin derivatives |
| UA85937C2 (uk) * | 2004-12-21 | 2009-03-10 | Пфайзер Продактс Інк. | Макроліди |
| US7595300B2 (en) | 2005-12-13 | 2009-09-29 | Kosan Biosciences Incorporated | 7-quinolyl ketolide antibacterial agents |
| CN101917850B (zh) * | 2007-10-25 | 2016-01-13 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
| WO2009098320A2 (en) * | 2008-02-08 | 2009-08-13 | Basilea Pharmaceutica Ag | Macrolides and uses of macrolides |
| CN102223794B (zh) | 2008-10-24 | 2017-12-22 | 森普拉制药公司 | 使用含三唑的大环内酯治疗抗性疾病的方法 |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| JP5914335B2 (ja) | 2009-09-10 | 2016-05-11 | センプラ ファーマシューティカルズ，インコーポレイテッド | マラリア、結核、及びｍａｃ病の治療方法 |
| BR112012023950A2 (pt) | 2010-03-22 | 2016-07-05 | Cempra Pharmaceuticals Inc | formas cristalinas de um macrolídeo, e usos dos mesmos |
| ES2636948T3 (es) | 2010-05-20 | 2017-10-10 | Cempra Pharmaceuticals, Inc. | Procesos para preparar macrólidos y cetólidos e intermediarios para los mismos |
| US8796474B1 (en) | 2010-08-23 | 2014-08-05 | Rutgers, The State University Of New Jersey | Macrolide compounds and methods and intermediates useful for their preparation |
| EP2613630A4 (en) | 2010-09-10 | 2014-01-15 | Cempra Pharmaceuticals Inc | FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES |
| CN103619849B (zh) * | 2011-03-01 | 2016-05-25 | 沃克哈特有限公司 | 酮内酯中间体的制备方法 |
| RU2658050C2 (ru) | 2012-03-27 | 2018-06-19 | Семпра Фармасьютикалз, Инк. | Парентеральные составы для введения макролидных антибиотиков |
| CN102718816B (zh) * | 2012-07-11 | 2014-11-05 | 山东大学 | 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物 |
| WO2014152326A1 (en) | 2013-03-14 | 2014-09-25 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| RU2015138797A (ru) | 2013-03-15 | 2017-04-24 | Семпра Фармасьютикалс, Инк. | Конвергентные способы получения макролидных антибактериальных агентов |
| US20230174567A1 (en) * | 2020-05-22 | 2023-06-08 | Merck Sharp & Dohme Llc | Synthesis of fluorinated nucleotides |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5141926A (en) | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
| IL114589A (en) * | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of the history of erythromycin |
| US5523399A (en) * | 1991-12-27 | 1996-06-04 | Taisho Pharmaceutical Co., Ltd. | 5-O-desosaminylerythronolide derivatives |
| JP3259429B2 (ja) * | 1992-04-22 | 2002-02-25 | 大正製薬株式会社 | ５−ｏ−デソサミニルエリスロノライドａ誘導体 |
| US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| US6066721A (en) | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
| US5672491A (en) | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| DE69634127D1 (de) | 1995-07-06 | 2005-02-03 | Univ Leland Stanford Junior | Zellfreie synthese von polyketiden |
| FR2739620B1 (fr) * | 1995-10-09 | 1997-12-19 | Roussel Uclaf | Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs |
| US6274715B1 (en) | 1995-11-08 | 2001-08-14 | Abbott Laboratories | Tricyclic erythromycin derivatives |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US5750510A (en) * | 1997-04-04 | 1998-05-12 | Abbott Laboratories | 3-descladinose-2,3-anhydroerythromycin derivatives |
| BR9708929A (pt) | 1996-05-07 | 1999-08-03 | Abbott Lab | Composto composição farmacêutica e processos para controlar uma infecção bacteriana em um mamífero e para preparar compostos de macrólidos |
| FR2748746B1 (fr) | 1996-05-14 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine |
| US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
| GB2331518B (en) | 1996-07-05 | 2001-03-14 | Biotica Tech Ltd | Erythromycins and process for their preparation |
| FR2751656B1 (fr) * | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| PT1291353E (pt) * | 1996-09-04 | 2005-10-31 | Abbott Lab | Cetolidos 6-o-substituidos possuindo actividade antibacteriana |
| UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| FR2754821B1 (fr) * | 1996-10-23 | 2003-04-04 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| AU4472797A (en) * | 1996-10-31 | 1998-05-22 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a derivatives |
| FR2757168B1 (fr) * | 1996-12-12 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| AU6041498A (en) * | 1997-02-04 | 1998-08-25 | Abbott Laboratories | Pain reducing parenteral liposome formulation |
| FR2760017B1 (fr) * | 1997-02-27 | 1999-04-30 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments |
| ID24529A (id) * | 1997-06-11 | 2000-07-20 | Pfizer Prod Inc | Turunan-turunan 9-oksima eritromisin |
| DK1025114T3 (da) * | 1997-09-30 | 2004-07-05 | Abbott Lab | 3'-N-modificerede 6-O-substituerede erythromycin-ketolidderivater med antibakteriel aktivitet |
| AU9649698A (en) * | 1997-10-29 | 1999-05-17 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a 11, 12-carbamate derivatives |
| CO4990960A1 (es) | 1997-10-29 | 2000-12-26 | Abbott Lab | Derivados de cetolidos 2-halo-6-o sustituidos |
| US6124269A (en) | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| DK0941998T3 (da) | 1998-03-03 | 2004-09-20 | Pfizer Prod Inc | 3,6-ketalmakrolidantibiotika |
| FR2777282B1 (fr) | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
| ES2199524T3 (es) * | 1998-04-24 | 2004-02-16 | Pfizer Products Inc. | Derivados 9a,11b-deshidro de 9-oxima-3-ceto-6-o-metileritromicina. |
| FR2781484B1 (fr) * | 1998-07-21 | 2001-08-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments |
| AU758421B2 (en) | 1998-10-29 | 2003-03-20 | Kosan Biosciences, Inc. | Recombinant oleandolide polyketide synthase |
| ID28286A (id) | 1998-11-03 | 2001-05-10 | Pfizer Prod Inc | Antibiotik-antibiotik makrolida baru |
| DE69933897T2 (de) | 1998-12-10 | 2007-03-15 | Pfizer Products Inc., Groton | Carbamat- und Carbazatketolid-Antibiotika |
| IL144178A0 (en) | 1999-01-27 | 2002-05-23 | Pfizer Prod Inc | Ketolide antibiotics |
| NZ513206A (en) * | 1999-03-15 | 2004-02-27 | Abbott Lab | 6-O-substituted macrolides having antibacterial activity |
| CA2370743A1 (en) | 1999-04-16 | 2000-10-26 | Dennis Hlasta | Ketolide antibacterials |
| CZ20013733A3 (cs) | 1999-05-24 | 2002-11-13 | Pfizer Products Inc. | Deriváty 13-methylerythromycinu |
-
2000
- 2000-04-14 ES ES00922149T patent/ES2272273T3/es not_active Expired - Lifetime
- 2000-04-14 AU AU42379/00A patent/AU773678B2/en not_active Ceased
- 2000-04-14 KR KR1020017013225A patent/KR20020007374A/ko not_active Application Discontinuation
- 2000-04-14 DE DE60030847T patent/DE60030847T2/de not_active Expired - Fee Related
- 2000-04-14 KR KR1020017013150A patent/KR100710605B1/ko not_active IP Right Cessation
- 2000-04-14 CA CA002369816A patent/CA2369816A1/en not_active Abandoned
- 2000-04-14 US US09/550,045 patent/US6395710B1/en not_active Expired - Lifetime
- 2000-04-14 BR BR0010680-1A patent/BR0010680A/pt not_active IP Right Cessation
- 2000-04-14 IL IL14577700A patent/IL145777A0/xx active IP Right Grant
- 2000-04-14 CN CNB008090718A patent/CN1241931C/zh not_active Expired - Fee Related
- 2000-04-14 JP JP2000612314A patent/JP2003523938A/ja active Pending
- 2000-04-14 WO PCT/US2000/009915 patent/WO2000063225A2/en not_active Application Discontinuation
- 2000-04-14 NZ NZ515027A patent/NZ515027A/xx unknown
- 2000-04-14 ID IDW00200102465A patent/ID30547A/id unknown
- 2000-04-14 MX MXPA01010524A patent/MXPA01010524A/es active IP Right Grant
- 2000-04-14 WO PCT/US2000/009914 patent/WO2000063224A2/en active IP Right Grant
- 2000-04-14 AT AT00922149T patent/ATE340183T1/de not_active IP Right Cessation
- 2000-04-14 AU AU44578/00A patent/AU775637B2/en not_active Ceased
- 2000-04-14 EP EP00922149A patent/EP1171446B1/en not_active Expired - Lifetime
-
2001
- 2001-10-04 IL IL145777A patent/IL145777A/en unknown
-
2002
- 2002-02-13 US US10/075,466 patent/US6593302B2/en not_active Ceased
-
2005
- 2005-07-13 US US11/182,038 patent/USRE39836E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60030847D1 (de) | 2006-11-02 |
| AU773678B2 (en) | 2004-06-03 |
| MXPA01010524A (es) | 2002-03-14 |
| KR100710605B1 (ko) | 2007-04-24 |
| AU4237900A (en) | 2000-11-02 |
| CA2369816A1 (en) | 2000-10-26 |
| WO2000063224A3 (en) | 2001-01-18 |
| ID30547A (id) | 2001-12-20 |
| IL145777A (en) | 2007-02-11 |
| CN1241931C (zh) | 2006-02-15 |
| USRE39836E1 (en) | 2007-09-11 |
| JP2003523938A (ja) | 2003-08-12 |
| KR20020007372A (ko) | 2002-01-26 |
| EP1171446B1 (en) | 2006-09-20 |
| WO2000063225A3 (en) | 2001-01-18 |
| AU775637B2 (en) | 2004-08-12 |
| KR20020007374A (ko) | 2002-01-26 |
| ATE340183T1 (de) | 2006-10-15 |
| WO2000063225A2 (en) | 2000-10-26 |
| WO2000063224A2 (en) | 2000-10-26 |
| NZ515027A (en) | 2004-01-30 |
| IL145777A0 (en) | 2002-07-25 |
| US20020119938A1 (en) | 2002-08-29 |
| AU4457800A (en) | 2000-11-02 |
| CN1384838A (zh) | 2002-12-11 |
| EP1171446A2 (en) | 2002-01-16 |
| US6593302B2 (en) | 2003-07-15 |
| US6395710B1 (en) | 2002-05-28 |
| DE60030847T2 (de) | 2007-04-19 |
| ES2272273T3 (es) | 2007-05-01 |
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