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BR0009341A - Compostos, composição farmacêutica, e, métodos para inibir simultaneamente processos biológicos mediados tanto pelo leucotrieno quanto pela histamina e para tratar asma, rinites alérgicas periódicas e perenes, sinusite, conjuntivite, alergia a alimentos, envenenamento escombróide, psorìase, urticária, prurido, eczema, artrite reumatóide, doença inflamatória do intestino, doença pulmonar obstrutiva crÈnica, doença trombótica e otite média - Google Patents

Compostos, composição farmacêutica, e, métodos para inibir simultaneamente processos biológicos mediados tanto pelo leucotrieno quanto pela histamina e para tratar asma, rinites alérgicas periódicas e perenes, sinusite, conjuntivite, alergia a alimentos, envenenamento escombróide, psorìase, urticária, prurido, eczema, artrite reumatóide, doença inflamatória do intestino, doença pulmonar obstrutiva crÈnica, doença trombótica e otite média

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Publication number
BR0009341A
BR0009341A BR0009341-6A BR0009341A BR0009341A BR 0009341 A BR0009341 A BR 0009341A BR 0009341 A BR0009341 A BR 0009341A BR 0009341 A BR0009341 A BR 0009341A
Authority
BR
Brazil
Prior art keywords
disease
compounds
histamine
periodic
leukotriene
Prior art date
Application number
BR0009341-6A
Other languages
English (en)
Inventor
Ralph Scannel
Pierre Chatelain
Anna Toy-Palmer
Edmond Differding
James Ellis
Marie-Agnes Lassoie
Michelle Young
Xiong Cai
Sajjat Hussoin
Gurmit Grewal
Timothy Lewis
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of BR0009341A publication Critical patent/BR0009341A/pt

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, MéTODOS PARA INIBIR SIMULTANEAMENTE PROCESSOS BIOLóGICOS MEDIADOS TANTO PELO LEUCOTRIENO QUANTO PELA HISTAMINA E PARA TRATAR ASMA, RINITES ALéRGICAS PERIóDICAS E PERENES, SINUSITE, CONJUNTIVITE, ALERGIA A ALIMENTOS, ENVENENAMENTO ESCOMBRóIDE, PSORìASE, URTICáRIA, PRURID0, ECZEMA, ARTRITE REUMATóIDE, DOENçA INFLAMATóRIA DO INTESTINO, DOENçA PULMONAR OBSTRUTIVA CRONICA, DOENçA TROMBóTICA E OTITE MéDIA". A presente invenção fornece compostos de piperazinas substituidas em 1,4, piperidinas substituidas em 1,4, e 4-alquilidenil piperidinas substituídas em 1. Os compostos da invençao são moléculas de ação dual tendo tanto propriedades de inibição de leucotrieno bem como propriedades antiistaminérgicas. Os compostos da invenção são úteis para tratar condições em que haja provavelmente um componente de histamina e/ou leucotrieno. Estas condições incluem preferivelmente asma, rinites alérgicas periódicas e perenes, sinusite, conjuntivite, alergia a alimentos, envenenamento escombróide, psoríase, urticária, prurido, eczema, artrite reumatóide, doença inflamatória do intestino, doença pulmonar obstrutiva crónica, doença trombótica e otite média. Também fornecidos são os métodos de tratar a asma e a rinite pela administração de uma quantidade eficaz que alivie a asma e a rinite, dos compostos a um paciente em necessidade desta.
BR0009341-6A 1999-03-26 2000-03-23 Compostos, composição farmacêutica, e, métodos para inibir simultaneamente processos biológicos mediados tanto pelo leucotrieno quanto pela histamina e para tratar asma, rinites alérgicas periódicas e perenes, sinusite, conjuntivite, alergia a alimentos, envenenamento escombróide, psorìase, urticária, prurido, eczema, artrite reumatóide, doença inflamatória do intestino, doença pulmonar obstrutiva crÈnica, doença trombótica e otite média BR0009341A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12652199P 1999-03-26 1999-03-26
PCT/BE2000/000026 WO2000058295A2 (en) 1999-03-26 2000-03-23 Compounds and methods for treatment of asthma, allergy and inflammatory disorders

Publications (1)

Publication Number Publication Date
BR0009341A true BR0009341A (pt) 2002-02-19

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BR0009341-6A BR0009341A (pt) 1999-03-26 2000-03-23 Compostos, composição farmacêutica, e, métodos para inibir simultaneamente processos biológicos mediados tanto pelo leucotrieno quanto pela histamina e para tratar asma, rinites alérgicas periódicas e perenes, sinusite, conjuntivite, alergia a alimentos, envenenamento escombróide, psorìase, urticária, prurido, eczema, artrite reumatóide, doença inflamatória do intestino, doença pulmonar obstrutiva crÈnica, doença trombótica e otite média

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US (3) US6451801B1 (pt)
EP (1) EP1165533B1 (pt)
JP (2) JP2002540198A (pt)
KR (1) KR20020005635A (pt)
CN (3) CN1160344C (pt)
AR (2) AR020026A1 (pt)
AT (1) ATE279401T1 (pt)
AU (1) AU761422B2 (pt)
BG (1) BG105909A (pt)
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CA (1) CA2368090A1 (pt)
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CZ (1) CZ20013471A3 (pt)
DE (1) DE60014876T2 (pt)
DZ (1) DZ3027A1 (pt)
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