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BG92810A - Метод за получаване на 23-(с долу 1-6 алкилоксим)- ll-f 28249 - Google Patents

Метод за получаване на 23-(с долу 1-6 алкилоксим)- ll-f 28249

Info

Publication number
BG92810A
BG92810A BG092810A BG9281090A BG92810A BG 92810 A BG92810 A BG 92810A BG 092810 A BG092810 A BG 092810A BG 9281090 A BG9281090 A BG 9281090A BG 92810 A BG92810 A BG 92810A
Authority
BG
Bulgaria
Prior art keywords
alkyloxime
preparation
nematocidal
ectoparasitic
anthelmintic
Prior art date
Application number
BG092810A
Other languages
English (en)
Other versions
BG60620B1 (bg
Inventor
Donald Maulding
Anil Kumar
Original Assignee
Wyeth Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings Corporation filed Critical Wyeth Holdings Corporation
Publication of BG92810A publication Critical patent/BG92810A/bg
Publication of BG60620B1 publication Critical patent/BG60620B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Liquid Crystal Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретението се отнася до метод за получаване на 23-/с1-6алкилоксим/-ll-f 28249 с формула получените антибиотични вещества са с повишен добив и чистота и намират приложение като антихелминтни, инсектицидни, нематоцидни, ектопаразитицидни и акарицидни средства. По метода се получават междинните 5-0-р-нитробензоил-ll-f 28249 съединения под формата на кристали, след което се окисляват до желаните крайни продукти. 6 претенции
BG92810A 1989-09-11 1990-09-10 Метод за получаване на 23-(с долу 1-6 алкилоксим)- ll-f 28249 BG60620B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/405,793 US4988824A (en) 1989-09-11 1989-09-11 Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds

Publications (2)

Publication Number Publication Date
BG92810A true BG92810A (bg) 1993-12-24
BG60620B1 BG60620B1 (bg) 1995-10-31

Family

ID=23605260

Family Applications (1)

Application Number Title Priority Date Filing Date
BG92810A BG60620B1 (bg) 1989-09-11 1990-09-10 Метод за получаване на 23-(с долу 1-6 алкилоксим)- ll-f 28249

Country Status (28)

Country Link
US (1) US4988824A (bg)
EP (1) EP0421081B1 (bg)
JP (1) JP2939312B2 (bg)
KR (1) KR0160977B1 (bg)
CN (1) CN1028428C (bg)
AT (1) ATE107650T1 (bg)
AU (1) AU634579B2 (bg)
BG (1) BG60620B1 (bg)
BR (1) BR9004493A (bg)
CA (1) CA2024919C (bg)
DE (1) DE69010129T2 (bg)
DK (1) DK0421081T3 (bg)
ES (1) ES2057291T3 (bg)
GE (1) GEP19981003B (bg)
HK (1) HK1000095A1 (bg)
HU (1) HU206721B (bg)
IE (1) IE66030B1 (bg)
IL (1) IL95303A (bg)
LV (1) LV10503B (bg)
MD (1) MD425C2 (bg)
NZ (1) NZ235151A (bg)
PL (1) PL165332B1 (bg)
PT (1) PT95242B (bg)
RU (1) RU2030416C1 (bg)
SI (1) SI9011711A (bg)
UA (1) UA26907C2 (bg)
YU (1) YU47520B (bg)
ZA (1) ZA907186B (bg)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU660205B2 (en) 1991-12-23 1995-06-15 Virbac, Inc Systemic control of parasites
US5439924A (en) * 1991-12-23 1995-08-08 Virbac, Inc. Systemic control of parasites
US5478951A (en) * 1994-06-22 1995-12-26 American Cyanamid Company Method for the purification of 23-E isomers of 23-imino derivatives of LL-F28249 compounds
BR9607262A (pt) * 1995-02-24 1997-12-30 Norvatis Ag Novartis Sa Novart Composição para controlar parasitas
EP0750907B1 (en) * 1995-06-30 2002-03-20 American Cyanamid Company Stable macrolide and macrolide vaccine compositions
WO1999017760A2 (en) 1997-10-02 1999-04-15 Microcide Pharmaceuticals, Inc. Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug
US6762327B2 (en) * 2002-04-29 2004-07-13 Wyeth Selective oxidation process with enhanced safety
US7348417B2 (en) 2003-08-07 2008-03-25 Wyeth Method of purifying moxidectin through crystallization
NZ548932A (en) * 2006-05-08 2007-01-26 Wyeth Corp Intermediates and processes using them for preparing moxidectin
AU2006203349B2 (en) * 2006-05-08 2008-01-31 Wyeth Process
NZ548936A (en) * 2006-06-22 2007-02-23 Wyeth Corp Selective oxidation of LL-F28249-alpha using o-iodoxybenzoic acid
AU2012345813B2 (en) 2011-12-02 2017-02-02 Boehringer lngelheim Vetmedica GMBH Long-acting injectable moxidectin formulations and novel moxidectin crystal forms
CN104277050B (zh) * 2013-07-04 2016-05-04 北大方正集团有限公司 一种制备莫西克汀的方法
CN104017001B (zh) * 2014-06-18 2016-01-13 大连九信生物化工科技有限公司 一种化学合成莫西克汀的方法
CN104292239A (zh) * 2014-09-30 2015-01-21 大连九信生物化工科技有限公司 一种消除莫西克汀生产过程中副产物二甲基硫醚的方法
CN104628740B (zh) * 2015-02-13 2017-06-16 河北圣雪大成制药有限责任公司 一种化学合成及纯化莫西克汀的方法
CN104860961B (zh) * 2015-04-10 2017-08-04 新宇药业股份有限公司 一种制备5‑氧（对‑硝基苯甲酰）‑尼莫克汀的方法
CN105085540B (zh) * 2015-08-12 2017-07-07 内蒙古佳瑞米精细化工有限公司 一种制备高含量尼莫克汀的方法
CN114591347B (zh) * 2022-03-29 2023-03-24 河北美荷药业有限公司 莫西菌素中间体及制备方法、莫西菌素的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
AU596586B2 (en) * 1985-04-30 1990-05-10 American Cyanamid Company Chemical derivatives of antibiotics S541
CA1296329C (en) * 1986-06-06 1992-02-25 Derek R. Sutherland Macrolide compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
ES2058082T3 (es) * 1986-09-12 1994-11-01 American Cyanamid Co Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249.
US4855317A (en) * 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
GB8721376D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
ES2082774T3 (es) * 1988-05-10 1996-04-01 American Cyanamid Co Compuestos macrolidos.
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
US4900758A (en) * 1989-05-11 1990-02-13 Ici Americas Inc. Novel insecticides
EP0423445B1 (en) * 1989-09-11 1995-11-08 American Cyanamid Company 13-alkyl-23-imino and 13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal insecticidal, acaricidal and nematocidal agents

Also Published As

Publication number Publication date
HUT55019A (en) 1991-04-29
AU6236290A (en) 1991-03-14
NZ235151A (en) 1992-11-25
ZA907186B (en) 1991-06-26
DE69010129D1 (de) 1994-07-28
BG60620B1 (bg) 1995-10-31
MD425C2 (ro) 1997-04-30
HK1000095A1 (en) 1997-11-21
LV10503A (lv) 1995-02-20
GEP19981003B (en) 1998-10-27
US4988824A (en) 1991-01-29
BR9004493A (pt) 1991-09-10
JPH03141283A (ja) 1991-06-17
JP2939312B2 (ja) 1999-08-25
KR0160977B1 (ko) 1998-12-01
CN1051043A (zh) 1991-05-01
IL95303A (en) 1994-11-28
IE903273A1 (en) 1991-03-27
IL95303A0 (en) 1991-06-30
HU206721B (en) 1992-12-28
UA26907C2 (uk) 1999-12-29
ES2057291T3 (es) 1994-10-16
YU47520B (sh) 1995-10-03
CN1028428C (zh) 1995-05-17
CA2024919C (en) 2001-12-11
EP0421081A1 (en) 1991-04-10
PL286824A1 (en) 1991-08-12
AU634579B2 (en) 1993-02-25
EP0421081B1 (en) 1994-06-22
PL165332B1 (pl) 1994-12-30
ATE107650T1 (de) 1994-07-15
HU905842D0 (en) 1991-03-28
DE69010129T2 (de) 1995-01-26
YU171190A (sh) 1992-07-20
CA2024919A1 (en) 1991-03-12
PT95242A (pt) 1991-05-22
KR910006490A (ko) 1991-04-29
LV10503B (en) 1996-04-20
RU2030416C1 (ru) 1995-03-10
IE66030B1 (en) 1995-11-29
SI9011711A (sl) 1998-02-28
PT95242B (pt) 1997-06-30
DK0421081T3 (da) 1994-07-25

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