BG62618B1 - Асиметрично заместени ксантини с аденозинантагонистичнисвойства, метод за тяхното получаване и междинни съединения затази цел, приложение на тези съединения като фармакологичнисредства, фармацевтични смеси, които ги съдържат, и метод затяхното получаване - Google Patents
Асиметрично заместени ксантини с аденозинантагонистичнисвойства, метод за тяхното получаване и междинни съединения затази цел, приложение на тези съединения като фармакологичнисредства, фармацевтични смеси, които ги съдържат, и метод затяхното получаване Download PDFInfo
- Publication number
- BG62618B1 BG62618B1 BG99489A BG9948995A BG62618B1 BG 62618 B1 BG62618 B1 BG 62618B1 BG 99489 A BG99489 A BG 99489A BG 9948995 A BG9948995 A BG 9948995A BG 62618 B1 BG62618 B1 BG 62618B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- och
- conr
- radical
- substituted
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4226371 | 1992-08-10 | ||
| DE4238423 | 1992-11-13 | ||
| PCT/EP1993/002077 WO1994003456A1 (de) | 1992-08-10 | 1993-08-05 | Unsymmetrisch substituierte xanthine mit adenosinantagonistischen eigenschaften |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG99489A BG99489A (bg) | 1996-01-31 |
| BG62618B1 true BG62618B1 (bg) | 2000-03-31 |
Family
ID=25917371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG99489A BG62618B1 (bg) | 1992-08-10 | 1995-03-09 | Асиметрично заместени ксантини с аденозинантагонистичнисвойства, метод за тяхното получаване и междинни съединения затази цел, приложение на тези съединения като фармакологичнисредства, фармацевтични смеси, които ги съдържат, и метод затяхното получаване |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5719279A (sh) |
| EP (1) | EP0654033A1 (sh) |
| JP (1) | JPH08500344A (sh) |
| KR (1) | KR950702988A (sh) |
| CN (1) | CN1043348C (sh) |
| AU (1) | AU681348B2 (sh) |
| BG (1) | BG62618B1 (sh) |
| CA (1) | CA2140883A1 (sh) |
| CZ (1) | CZ286459B6 (sh) |
| FI (1) | FI950542A0 (sh) |
| HU (1) | HUT65734A (sh) |
| IL (1) | IL106624A (sh) |
| MX (1) | MX9304819A (sh) |
| NZ (1) | NZ254804A (sh) |
| PL (1) | PL176389B1 (sh) |
| RU (1) | RU2138500C1 (sh) |
| SG (1) | SG55038A1 (sh) |
| SK (1) | SK18595A3 (sh) |
| TW (1) | TW252044B (sh) |
| UA (1) | UA46697C2 (sh) |
| WO (1) | WO1994003456A1 (sh) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW252044B (sh) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| US5877179A (en) * | 1992-09-29 | 1999-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells |
| AU6781194A (en) * | 1993-05-03 | 1994-11-21 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists |
| DE4316576A1 (de) * | 1993-05-18 | 1994-11-24 | Boehringer Ingelheim Kg | Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin |
| US5646156A (en) * | 1994-04-25 | 1997-07-08 | Merck & Co., Inc. | Inhibition of eosinophil activation through A3 adenosine receptor antagonism |
| US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| GB9415529D0 (en) | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
| ATE247116T1 (de) * | 1994-12-13 | 2003-08-15 | Euro Celtique Sa | Arylthioxanthine |
| EP0799040B1 (en) | 1994-12-13 | 2003-08-20 | Euroceltique S.A. | Trisubstituted thioxanthines |
| US5864037A (en) | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
| GB9623859D0 (en) * | 1996-11-15 | 1997-01-08 | Chiroscience Ltd | Novel compounds |
| US5786360A (en) * | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
| GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| US6248746B1 (en) | 1998-01-07 | 2001-06-19 | Euro-Celtique S.A. | 3-(arylalkyl) xanthines |
| WO1999031101A1 (en) * | 1997-12-17 | 1999-06-24 | University Of South Florida | Adenosine receptor antagonists with improved bioactivity |
| DE19816857A1 (de) * | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU4980999A (en) | 1998-07-10 | 2000-02-01 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | A3 adenosine receptor antagonists |
| GB9817623D0 (en) | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| UA77391C2 (en) * | 1999-11-12 | 2006-12-15 | Biogen Inc | Polycycloalkylpurines as antagonists of adenosine receptors |
| GEP20043267B (en) | 1999-11-12 | 2004-06-25 | Biogen Inc Us | Adenosine Receptor Antagonists, Methods of Making and Using the Same |
| US7005430B2 (en) * | 1999-12-24 | 2006-02-28 | Kyowa Hakko Kogyo Co., Ltd. | Fused purine derivatives |
| AU3091301A (en) | 2000-01-14 | 2001-07-24 | Us Health | Methanocarba cycloalkyl nucleoside analogues |
| HU230382B1 (hu) * | 2001-02-24 | 2016-03-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xantinszármazékok, előállításuk és alkalmazásuk gyógyszerként |
| UA80258C2 (en) * | 2001-09-06 | 2007-09-10 | Biogen Inc | Methods of treating pulmonary disease |
| AU2003231805A1 (en) | 2002-06-17 | 2004-02-09 | Glaxo Group Limited | Purine derivatives as liver x receptor agonists |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7569574B2 (en) | 2002-08-22 | 2009-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Purine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| US7495005B2 (en) | 2002-08-22 | 2009-02-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, their preparation and their use in pharmaceutical compositions |
| US7482337B2 (en) | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| DE10254304A1 (de) | 2002-11-21 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| JP2006518390A (ja) | 2003-02-19 | 2006-08-10 | エンダシア，インコーポレイテッド | Ａ１アデノシンレセプターアンタゴニスト |
| US7579331B2 (en) | 2003-04-25 | 2009-08-25 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| US7247639B2 (en) * | 2003-06-06 | 2007-07-24 | Endacea, Inc. | A1 adenosine receptor antagonists |
| EP1636230A4 (en) * | 2003-06-09 | 2010-06-16 | Endacea Inc | ADENOSINE A1 RECEPTOR ANTAGONISTS |
| US7566707B2 (en) | 2003-06-18 | 2009-07-28 | Boehringer Ingelheim International Gmbh | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions |
| DE10355304A1 (de) * | 2003-11-27 | 2005-06-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004009039A1 (de) | 2004-02-23 | 2005-09-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel |
| US7393847B2 (en) | 2004-03-13 | 2008-07-01 | Boehringer Ingleheim International Gmbh | Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions |
| US7179809B2 (en) * | 2004-04-10 | 2007-02-20 | Boehringer Ingelheim International Gmbh | 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions |
| US7439370B2 (en) | 2004-05-10 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides |
| DE102004030502A1 (de) | 2004-06-24 | 2006-01-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel |
| DE102004043944A1 (de) | 2004-09-11 | 2006-03-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(3-Amino-piperidin-1-yl)-7-(but-2-inyl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004044221A1 (de) | 2004-09-14 | 2006-03-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 3-Methyl-7-butinyl-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| CA2810522A1 (en) * | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Polymorphs |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| JP2010500326A (ja) * | 2006-08-08 | 2010-01-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病の治療のためのｄｐｐ−ｉｖ阻害剤としてのピロロ［３，２−ｄ］ピリミジン |
| ES2733348T3 (es) * | 2007-08-17 | 2019-11-28 | Boehringer Ingelheim Int | Derivados de purina para uso en el tratamiento de enfermedades relacionadas con FAP |
| JP5603248B2 (ja) | 2007-12-21 | 2014-10-08 | エンダセア， インコーポレイテッド | Ａ１アデノシン受容体アンタゴニスト |
| US7928259B2 (en) * | 2008-02-12 | 2011-04-19 | Frx Polymers, Inc. | Diaryl alkylphosphonates and methods for preparing same |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| JP5906086B2 (ja) * | 2008-08-15 | 2016-04-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｆａｂ関連疾患の治療に用いるためのプリン誘導体 |
| CN102149407A (zh) | 2008-09-10 | 2011-08-10 | 贝林格尔.英格海姆国际有限公司 | 治疗糖尿病和相关病症的组合疗法 |
| JP5334511B2 (ja) * | 2008-09-22 | 2013-11-06 | 日本精化株式会社 | 化粧料 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| CA2745037C (en) | 2008-12-23 | 2020-06-23 | Boehringer Ingelheim International Gmbh | Salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8(3-(r)-amino-piperidin-1-yl)-xanthine |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| JP2012521411A (ja) * | 2009-03-26 | 2012-09-13 | マピ ファーマ リミテッド | アログリプチンの調製プロセス |
| AU2010323068B2 (en) | 2009-11-27 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin |
| WO2011068978A1 (en) | 2009-12-02 | 2011-06-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methanocarba adenosine derivatives and dendrimer conjugates thereof |
| MX366325B (es) | 2010-05-05 | 2019-07-05 | Boehringer Ingelheim Int | Terapia de combinacion. |
| KR20230051307A (ko) | 2010-06-24 | 2023-04-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| US8962636B2 (en) | 2011-07-15 | 2015-02-24 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| WO2015128453A1 (en) | 2014-02-28 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Medical use of a dpp-4 inhibitor |
| WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
| RU2643336C1 (ru) * | 2016-10-03 | 2018-01-31 | Общество с Ограниченной Ответственностью "Компания "ЭЛТА" | СРЕДСТВО, ПРОЯВЛЯЮЩЕЕ АНТИТРОМБОТИЧЕСКИЙ ЭФФЕКТ ПОСРЕДСТВОМ БЛОКИРОВАНИЯ РЕЦЕПТОРОВ ТРОМБОЦИТОВ ГП IIb-IIIa (ВАРИАНТЫ) |
| CN109796453A (zh) * | 2019-02-12 | 2019-05-24 | 南京纽邦生物科技有限公司 | 一种1,7-二甲基黄嘌呤的制备方法 |
| WO2022079245A1 (en) | 2020-10-15 | 2022-04-21 | Rheinische-Friedrich-Wilhelms-Universität Bonn | 3-substituted xanthine derivatives as mrgprx4 receptor modulators |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452788A (en) * | 1982-04-21 | 1984-06-05 | Warner-Lambert Company | Substituted 8-phenylxanthines |
| US4593095A (en) * | 1983-02-18 | 1986-06-03 | The Johns Hopkins University | Xanthine derivatives |
| US4696932A (en) * | 1984-10-26 | 1987-09-29 | The United States Of America As Represented By The Department Of Health And Human Services | Biologically-active xanthine derivatives |
| GB8510758D0 (en) * | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
| US4772607A (en) * | 1986-05-20 | 1988-09-20 | Warner-Lambert Company | Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
| US4783530A (en) * | 1986-11-13 | 1988-11-08 | Marion Laboratories, Inc. | 8-arylxanthines |
| US4968672A (en) * | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
| US5032593A (en) * | 1988-07-01 | 1991-07-16 | Marion Merrell Dow Inc. | Method of treating bronchoconstriction with 1,3-unsymmetrical straight chain alkyl-substituted 8-phenylxanthines |
| DE8817122U1 (de) * | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Xanthinderivate mit Adenosinantogenistischer Wirkung |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| ES2130138T3 (es) * | 1990-10-18 | 1999-07-01 | Kyowa Hakko Kogyo Kk | Derivado de xantina. |
| CA2061544A1 (en) * | 1991-02-25 | 1992-08-26 | Fumio Suzuki | Xanthine compounds |
| TW252044B (sh) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| US5366977A (en) * | 1992-09-29 | 1994-11-22 | The United States Of America, As Represented By The Department Of Health And Human Services | Method of treating cystic fibrosis using 8-cyclopentyl-1,3-dipropylxanthine or xanthine amino congeners |
-
1993
- 1993-08-02 TW TW082106170A patent/TW252044B/zh active
- 1993-08-05 NZ NZ254804A patent/NZ254804A/en unknown
- 1993-08-05 UA UA95038235A patent/UA46697C2/uk unknown
- 1993-08-05 JP JP6505017A patent/JPH08500344A/ja active Pending
- 1993-08-05 SG SG1996003249A patent/SG55038A1/en unknown
- 1993-08-05 EP EP93917743A patent/EP0654033A1/de not_active Withdrawn
- 1993-08-05 PL PL93307397A patent/PL176389B1/pl unknown
- 1993-08-05 AU AU47071/93A patent/AU681348B2/en not_active Ceased
- 1993-08-05 WO PCT/EP1993/002077 patent/WO1994003456A1/de active IP Right Grant
- 1993-08-05 RU RU95109100A patent/RU2138500C1/ru active
- 1993-08-05 CZ CZ1995348A patent/CZ286459B6/cs not_active IP Right Cessation
- 1993-08-05 CA CA002140883A patent/CA2140883A1/en not_active Abandoned
- 1993-08-05 SK SK185-95A patent/SK18595A3/sk unknown
- 1993-08-09 IL IL10662493A patent/IL106624A/en not_active IP Right Cessation
- 1993-08-09 MX MX9304819A patent/MX9304819A/es not_active IP Right Cessation
- 1993-08-09 HU HU9302302A patent/HUT65734A/hu unknown
- 1993-08-10 CN CN93109282A patent/CN1043348C/zh not_active Expired - Fee Related
-
1995
- 1995-02-08 FI FI950542A patent/FI950542A0/fi unknown
- 1995-02-10 KR KR1019950700569A patent/KR950702988A/ko not_active Application Discontinuation
- 1995-03-09 BG BG99489A patent/BG62618B1/bg unknown
-
1996
- 1996-06-11 US US08/661,567 patent/US5719279A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HUT65734A (en) | 1994-07-28 |
| CA2140883A1 (en) | 1994-02-17 |
| IL106624A (en) | 1999-01-26 |
| CN1043348C (zh) | 1999-05-12 |
| NZ254804A (en) | 1997-01-29 |
| CN1086818A (zh) | 1994-05-18 |
| RU95109100A (ru) | 1996-12-27 |
| FI950542A (fi) | 1995-02-08 |
| FI950542A0 (fi) | 1995-02-08 |
| JPH08500344A (ja) | 1996-01-16 |
| IL106624A0 (en) | 1993-12-08 |
| MX9304819A (es) | 1994-02-28 |
| PL307397A1 (en) | 1995-05-15 |
| SK18595A3 (en) | 1995-07-11 |
| EP0654033A1 (de) | 1995-05-24 |
| HU9302302D0 (en) | 1993-10-28 |
| BG99489A (bg) | 1996-01-31 |
| SG55038A1 (en) | 1998-12-21 |
| PL176389B1 (pl) | 1999-05-31 |
| AU4707193A (en) | 1994-03-03 |
| CZ286459B6 (en) | 2000-04-12 |
| TW252044B (sh) | 1995-07-21 |
| AU681348B2 (en) | 1997-08-28 |
| KR950702988A (ko) | 1995-08-23 |
| RU2138500C1 (ru) | 1999-09-27 |
| UA46697C2 (uk) | 2002-06-17 |
| CZ34895A3 (en) | 1995-10-18 |
| WO1994003456A1 (de) | 1994-02-17 |
| US5719279A (en) | 1998-02-17 |
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