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BG47040A3 - Метод за получаване на а-21978 с циклични пептидни производни - Google Patents

Метод за получаване на а-21978 с циклични пептидни производни

Info

Publication number
BG47040A3
BG47040A3 BG071957A BG7195785A BG47040A3 BG 47040 A3 BG47040 A3 BG 47040A3 BG 071957 A BG071957 A BG 071957A BG 7195785 A BG7195785 A BG 7195785A BG 47040 A3 BG47040 A3 BG 47040A3
Authority
BG
Bulgaria
Prior art keywords
preparing
derivatives
side chain
cyclic
peptidic derivatives
Prior art date
Application number
BG071957A
Other languages
English (en)
Inventor
Floyd M Huber
Richard L Pieper
Anthony J Tietz
Tom E Eaton
Lynda M Ford
Otis W Godfrey
Mary L Braun
Milton J Zmijewski
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of BG47040A3 publication Critical patent/BG47040A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Treating Waste Gases (AREA)
  • Pyrane Compounds (AREA)

Abstract

Методът намира приложение в медицината за производство на антибиотици с превъзходни антибактериални свойства и осигурява получаване на а-21978с циклични пептиди производни с с долу 2с долу 14-алканоилова странична верига по нов начин. Продуктите се получават в по-малко етапи с повишен добив. Съгласно метода а-21978с цикличните пептидни производни с с долу 2-с долу 14-алканоилова странична верига се получават, като в произвеждащата а-21978с култура се внася съответната с долу 2-с долу 14-алканова киселина, естер или сол на същата. 11претенции
BG071957A 1984-10-09 1985-10-08 Метод за получаване на а-21978 с циклични пептидни производни BG47040A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65897984A 1984-10-09 1984-10-09

Publications (1)

Publication Number Publication Date
BG47040A3 true BG47040A3 (bg) 1990-04-16

Family

ID=24643546

Family Applications (1)

Application Number Title Priority Date Filing Date
BG071957A BG47040A3 (bg) 1984-10-09 1985-10-08 Метод за получаване на а-21978 с циклични пептидни производни

Country Status (27)

Country Link
EP (1) EP0178152B1 (bg)
JP (1) JPH0787796B2 (bg)
KR (1) KR890000800B1 (bg)
CN (2) CN1013120B (bg)
AT (1) ATE67788T1 (bg)
AU (2) AU4837785A (bg)
BG (1) BG47040A3 (bg)
CS (2) CS276978B6 (bg)
CY (1) CY1633A (bg)
DD (2) DD238068A5 (bg)
DE (1) DE3584218D1 (bg)
DK (2) DK165416C (bg)
EG (1) EG17619A (bg)
ES (2) ES8700862A1 (bg)
FI (1) FI82075C (bg)
GR (1) GR852432B (bg)
HK (1) HK24292A (bg)
HU (1) HU196845B (bg)
IE (1) IE58655B1 (bg)
IL (1) IL76608A (bg)
NZ (1) NZ213731A (bg)
PH (1) PH21217A (bg)
PL (1) PL152359B1 (bg)
PT (1) PT81265B (bg)
SG (1) SG3292G (bg)
SU (1) SU1452484A3 (bg)
ZA (1) ZA857759B (bg)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0294990A3 (en) * 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
US4930494A (en) * 1988-03-09 1990-06-05 Olympus Optical Co., Ltd. Apparatus for bending an insertion section of an endoscope using a shape memory alloy
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
DE3832362A1 (de) * 1988-09-23 1990-03-29 Sandoz Ag Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung
CN1423656A (zh) * 1999-12-15 2003-06-11 卡比斯特制药公司 作为抗菌剂的脂肽
EP1884520A3 (en) 1999-12-15 2008-03-05 Cubist Pharmaceuticals, Inc. Daptomycin analogs as antibacterial agents
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
SI2379580T1 (sl) 2008-12-22 2014-02-28 Cubist Pharmaceuticals, Inc. Nova antibakterijska sredstva za zdravljenje grampozitivnih okuĹľb
DK2504353T4 (da) 2009-11-23 2023-11-20 Cubist Pharmaceuticals Llc Lipopeptidsammensætninger og tilsvarende fremgangsmåder
EA032840B8 (ru) 2011-06-22 2020-06-18 Вайоми Терапеутикс Лимитед Пролекарства на основе конъюгатов противогрибковых агентов и их применение
IT201600127655A1 (it) 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
CN107964557B (zh) * 2018-01-17 2020-11-20 自然资源部第三海洋研究所 一种提高芽孢杆菌抗菌脂肽产量的发酵方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208403A (en) * 1978-10-16 1980-06-17 Eli Lilly And Company A-21978 Antibiotics and process for their production
IL68700A0 (en) * 1982-05-21 1983-09-30 Lilly Co Eli Improvements relating to a-21978c cyclic peptide derivatives and their production

Also Published As

Publication number Publication date
DK148791A (da) 1991-08-21
DE3584218D1 (de) 1991-10-31
EG17619A (en) 1991-03-30
CN1013120B (zh) 1991-07-10
CN85107552A (zh) 1987-05-20
IE852466L (en) 1986-04-09
DK165757C (da) 1993-06-07
KR890000800B1 (ko) 1989-04-07
DK457585D0 (da) 1985-10-08
FI82075C (fi) 1991-01-10
DK148791D0 (da) 1991-08-21
CS719885A3 (en) 1992-03-18
NZ213731A (en) 1988-04-29
FI82075B (fi) 1990-09-28
CS276983B6 (en) 1992-11-18
DK457585A (da) 1986-04-10
AU634766B2 (en) 1993-03-04
HUT39782A (en) 1986-10-29
IL76608A0 (en) 1986-02-28
ES8700862A1 (es) 1986-11-16
DK165416B (da) 1992-11-23
HU196845B (en) 1989-01-30
DD247023A5 (de) 1987-06-24
CY1633A (en) 1992-11-06
FI853910L (fi) 1986-04-10
ES553603A0 (es) 1987-11-01
CS819286A3 (en) 1992-03-18
IL76608A (en) 1991-03-10
IE58655B1 (en) 1993-11-03
FI853910A0 (fi) 1985-10-08
PT81265B (pt) 1988-02-17
DD238068A5 (de) 1986-08-06
AU5375290A (en) 1990-11-01
DK165416C (da) 1993-04-05
SU1452484A3 (ru) 1989-01-15
KR860003335A (ko) 1986-05-23
ATE67788T1 (de) 1991-10-15
JPS6192588A (ja) 1986-05-10
JPH0787796B2 (ja) 1995-09-27
PT81265A (en) 1985-11-01
PL152359B1 (en) 1990-12-31
DK165757B (da) 1993-01-11
EP0178152A2 (en) 1986-04-16
PH21217A (en) 1987-08-21
PL255683A1 (en) 1986-07-29
ZA857759B (en) 1987-05-27
EP0178152A3 (en) 1988-11-02
CN1051200A (zh) 1991-05-08
AU4837785A (en) 1986-04-17
GR852432B (bg) 1986-02-10
CS276978B6 (en) 1992-11-18
ES8800362A1 (es) 1987-11-01
EP0178152B1 (en) 1991-09-25
SG3292G (en) 1992-03-20
HK24292A (en) 1992-04-10
ES547689A0 (es) 1986-11-16

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