BG22831A3 - METHOD FOR OBTAINING AMIDE DERIVATIVES OF VINBLASTINE - Google Patents

METHOD FOR OBTAINING AMIDE DERIVATIVES OF VINBLASTINE

Info

Publication number: BG22831A3
Authority: BG; Bulgaria
Prior art keywords: vinblastine; amide derivatives; obtaining amide; obtaining; derivatives
Prior art date: 1973-04-02

Application number

BG026279A

Other languages

Bulgarian (bg)

Inventor

George Cullinan

Koert Gerzon

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-02

Filing date

1974-04-02

Publication date

1977-04-20

1974-04-02 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

1977-04-20 Publication of BG22831A3 publication Critical patent/BG22831A3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Fodder In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

BG026279A 1973-04-02 1974-04-02 METHOD FOR OBTAINING AMIDE DERIVATIVES OF VINBLASTINE BG22831A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34727573A	1973-04-02	1973-04-02

Publications (1)

Publication Number	Publication Date
BG22831A3 true BG22831A3 (en)	1977-04-20

Family

ID=23363051

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
BG028513A BG21612A3 (en)	1973-04-02	1974-04-02	METHOD FOR OBTAINING AMIDE DERIVATIVES OF LEVROCRISTIN
BG028514A BG21235A3 (en)	1973-04-02	1974-04-02	METHOD FOR PREPARING AMIDE DERIVATIVES OF LEVROSIDINE
BG026279A BG22831A3 (en)	1973-04-02	1974-04-02	METHOD FOR OBTAINING AMIDE DERIVATIVES OF VINBLASTINE

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
BG028513A BG21612A3 (en)	1973-04-02	1974-04-02	METHOD FOR OBTAINING AMIDE DERIVATIVES OF LEVROCRISTIN
BG028514A BG21235A3 (en)	1973-04-02	1974-04-02	METHOD FOR PREPARING AMIDE DERIVATIVES OF LEVROSIDINE

Country Status (28)

Country	Link
JP (2)	JPS5919117B2 (en)
AR (2)	AR204004A1 (en)
AT (1)	AT340605B (en)
BE (1)	BE813168A (en)
BG (3)	BG21612A3 (en)
CA (1)	CA1042428A (en)
CH (1)	CH603669A5 (en)
CS (1)	CS185223B2 (en)
CY (1)	CY1044A (en)
DD (1)	DD113538A5 (en)
DE (1)	DE2415980A1 (en)
DK (1)	DK141511B (en)
ES (2)	ES424882A1 (en)
FR (1)	FR2223044B1 (en)
GB (1)	GB1463575A (en)
HK (1)	HK20180A (en)
HU (1)	HU171572B (en)
IE (1)	IE39071B1 (en)
IL (1)	IL44415A (en)
KE (1)	KE3028A (en)
MY (1)	MY8100025A (en)
NL (1)	NL181079C (en)
PH (1)	PH13623A (en)
RO (2)	RO77533A (en)
SE (1)	SE416206B (en)
SU (4)	SU731900A3 (en)
YU (3)	YU39719B (en)
ZA (1)	ZA741674B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
GR69783B (en) *	1976-09-08	1982-07-07	Lilly Co Eli
US4096148A (en) *	1976-12-06	1978-06-20	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en)	1976-12-06	1981-03-31	Eli Lilly And Company	Vinca alkaloid intermediates
USRE30560E (en) *	1976-12-06	1981-03-31	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en)	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) *	1978-05-15	1980-04-22	Eli Lilly And Company	Bridged cathranthus alkaloid dimers
US4357334A (en)	1980-03-20	1982-11-02	Eli Lilly And Company	Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (en) *	1981-12-08	1983-09-01	Omnichem Sa	N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
OA06421A (en) *	1980-06-10	1981-09-30	Omnium Chimique Sa	Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.
FR2623504B1 (en) *	1987-11-25	1990-03-09	Adir	NOVEL N- (VINBLASTINOYL-23) DERIVATIVES OF 1-AMINO METHYLPHOSPHONIC ACID, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUT76925A (en) *	1995-04-04	1998-01-28	MTA Enzimológiai Intézet	Bis-indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US5948750A (en) *	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6326402B1 (en)	1998-08-12	2001-12-04	Octamer, Inc.	Methods for treating viral infections using a compound capable of inhibiting microtubules
JP5475234B2 (en)	2005-01-21	2014-04-16	アステックス・セラピューティクス・リミテッド	Pharmaceutical compounds
CN101242822B (en)	2005-07-18	2011-08-24	彼帕科学公司	Medicine of ovarian cancer
CN101534836B (en)	2006-09-05	2011-09-28	彼帕科学公司	Use of PARP inhibition in preparing medicine for obesity
US8143447B2 (en)	2006-09-05	2012-03-27	Bipar Sciences, Inc.	Treatment of cancer
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
EP2073803B1 (en)	2006-10-12	2018-09-19	Astex Therapeutics Limited	Pharmaceutical combinations
RU2480211C2 (en)	2007-11-12	2013-04-27	Байпар Сайенсиз, Инк.	Method of treating breast cancer with compound of 4-iodine-3-nitrobenzamine in combination with anticancer agents
US10377774B2 (en) *	2013-04-19	2019-08-13	Jinan University	Vinblastine derivatives, preparation method therefor and application thereof
CN113456797B (en) *	2021-06-18	2024-03-08	暨南大学	Application of vinblastine derivatives in preparation of medicines for treating osteosarcoma and/or soft tissue sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine

1974
- 1974-01-01 AR AR253105A patent/AR204004A1/en active
- 1974-03-13 IE IE532/74A patent/IE39071B1/en unknown
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/en unknown
- 1974-03-13 IL IL44415A patent/IL44415A/en unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 CY CY1044A patent/CY1044A/en unknown
- 1974-03-25 YU YU817/74A patent/YU39719B/en unknown
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-03-29 CH CH446374A patent/CH603669A5/xx not_active IP Right Cessation
- 1974-04-01 SU SU742013753A patent/SU731900A3/en active
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/en not_active IP Right Cessation
- 1974-04-01 DK DK178774AA patent/DK141511B/en not_active IP Right Cessation
- 1974-04-01 AT AT267974A patent/AT340605B/en not_active IP Right Cessation
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/en unknown
- 1974-04-01 SE SE7404380A patent/SE416206B/en not_active IP Right Cessation
- 1974-04-01 CS CS7400002335A patent/CS185223B2/en unknown
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
- 1974-04-02 BG BG028513A patent/BG21612A3/en unknown
- 1974-04-02 ES ES424882A patent/ES424882A1/en not_active Expired
- 1974-04-02 BG BG028514A patent/BG21235A3/en unknown
- 1974-04-02 RO RO7498695A patent/RO77533A/en unknown
- 1974-04-02 DE DE2415980A patent/DE2415980A1/en active Granted
- 1974-04-02 BG BG026279A patent/BG22831A3/en unknown
- 1974-04-02 BE BE1005847A patent/BE813168A/en not_active IP Right Cessation
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/en not_active Expired
- 1974-04-02 RO RO78274A patent/RO73524B/en unknown
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/en active
- 1975-07-04 SU SU752151512A patent/SU784783A3/en active
- 1975-07-09 SU SU752152020A patent/SU652896A3/en active
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/en not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/en active
1980
- 1980-02-27 KE KE3028A patent/KE3028A/en unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/en unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/en unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/en unknown
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/en unknown
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/en not_active Expired

Also Published As

Publication number	Publication date
IL44415A0 (en)	1974-06-30
KE3028A (en)	1980-03-28
ATA267974A (en)	1977-04-15
FR2223044B1 (en)	1978-06-30
SU623522A3 (en)	1978-09-05
NL181079C (en)	1987-06-16
SU784783A3 (en)	1980-11-30
AU6671974A (en)	1975-09-18
FR2223044A1 (en)	1974-10-25
YU113880A (en)	1982-05-31
SU731900A3 (en)	1980-04-30
YU39719B (en)	1985-04-30
YU39875B (en)	1985-04-30
JPS49128000A (en)	1974-12-07
DD113538A5 (en)	1975-06-12
JPS6033837B2 (en)	1985-08-05
DE2415980C2 (en)	1989-11-09
BE813168A (en)	1974-10-02
IE39071B1 (en)	1978-08-02
DK141511C (en)	1980-09-29
DK141511B (en)	1980-04-08
IL44415A (en)	1978-08-31
ZA741674B (en)	1975-10-29
CH603669A5 (en)	1978-08-31
CS185223B2 (en)	1978-09-15
HK20180A (en)	1980-04-25
BG21235A3 (en)	1976-03-20
RO73524A (en)	1984-10-31
YU113980A (en)	1982-05-31
CY1044A (en)	1980-08-01
AR204004A1 (en)	1975-11-12
SE416206B (en)	1980-12-08
RO77533A (en)	1982-02-01
JPS5919117B2 (en)	1984-05-02
PH13623A (en)	1980-08-07
RO73524B (en)	1984-11-30
YU39876B (en)	1985-04-30
YU81774A (en)	1982-05-31
JPS59193895A (en)	1984-11-02
ES446571A1 (en)	1977-06-16
BG21612A3 (en)	1976-07-20
SU652896A3 (en)	1979-03-15
IE39071L (en)	1974-10-02
CA1042428A (en)	1978-11-14
NL7404423A (en)	1974-10-04
AT340605B (en)	1977-12-27
NL181079B (en)	1987-01-16
MY8100025A (en)	1981-12-31
DE2415980A1 (en)	1974-10-10
ES424882A1 (en)	1976-12-16
HU171572B (en)	1978-02-28
GB1463575A (en)	1977-02-02
AR203882A1 (en)	1975-10-31

Publication	Publication Date	Title
BG22831A3 (en)	1977-04-20	METHOD FOR OBTAINING AMIDE DERIVATIVES OF VINBLASTINE
FR2276043A1 (en)	1976-01-23	NEW DERIVATIVES OF BENZOCYCLOAMIDE
BG26515A3 (en)	1979-04-12	METHOD FOR OBTAINING ACYLAMINO DERIVATIVES
BG26531A4 (en)	1979-04-12	METHOD FOR OBTAINING BENZOXAZOLE DERIVATIVES
BG26518A3 (en)	1979-04-12	METHOD FOR OBTAINING PHENYL-ALKANE DERIVATIVES
BG26669A4 (en)	1979-05-15	METHOD FOR OBTAINING OXAZOLE DERIVATIVES
BG22390A3 (en)	1977-02-20	METHOD FOR OBTAINING ISOQUINOLINE DERIVATIVES
BG26400A3 (en)	1979-03-15	METHOD FOR OBTAINING DIAMINOCYCLITOL DERIVATIVES
BG22820A3 (en)	1977-04-20	METHOD FOR OBTAINING PYRAZOLONES-5
BG26948A3 (en)	1979-07-12	METHOD OF OBTAINING TRIACETONAMINE
BG26527A3 (en)	1979-04-12	METHOD FOR PREPARATION OF 2-ARYLAMINO-2-IMIDAZOLINE DERIVATIVES
BG26396A3 (en)	1979-03-15	METHOD FOR PREPARATION OF POLY-N-ALKYLIMINOALANES
BG26529A3 (en)	1979-04-12	METHOD FOR OBTAINING BENZODIAZEPINE DERIVATIVES
BE822780A (en)	1975-05-29	DERIVATIVES OF CEPHEME
BG22832A3 (en)	1977-04-20	METHOD FOR OBTAINING LYSERGIC AMIDES
BG21849A3 (en)	1976-09-20	METHOD FOR OBTAINING SUBSTITUTED NITROBENZOPHENONE DERIVATIVES
BG27089A3 (en)	1979-08-15	METHOD FOR OBTAINING INDOQUINOLISIDINE DERIVATIVES
BG27076A3 (en)	1979-08-15	METHOD FOR OBTAINING ACETYLOCTENNITRILE DERIVATIVE
BE823197A (en)	1975-06-11	ORGANOSULPHIDE DERIVATIVES OF TETRACHLORODICYANOBENZENES
BG21033A3 (en)	1976-01-20	METHOD FOR OBTAINING DERIVATIVES OF 6-AMINOPENICILLIC ACID
BE828679A (en)	1975-09-01	NEW DERIVATIVES OF BENZIMIDAZOLE
BG26367A4 (en)	1979-03-15	METHOD FOR OBTAINING ARYLOXYAMINOBUTANOL AND ITS DERIVATIVES
BG25993A3 (en)	1979-01-12	METHOD FOR OBTAINING BENZOXAZOLE DERIVATIVES
SU457702A1 (en)	1975-01-25	The method of obtaining derivatives of 2-phenanthanopyrimidine
PL193421A1 (en)	1978-04-24	METHOD OF MAKING NEW DERIVATIVES OF CHINAZOLINE