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BG105561A - Фенилфенантридини с pde - iv инхибираща активност - Google Patents

Фенилфенантридини с pde - iv инхибираща активност

Info

Publication number
BG105561A
BG105561A BG105561A BG10556101A BG105561A BG 105561 A BG105561 A BG 105561A BG 105561 A BG105561 A BG 105561A BG 10556101 A BG10556101 A BG 10556101A BG 105561 A BG105561 A BG 105561A
Authority
BG
Bulgaria
Prior art keywords
phenylphenanthridines
pde
inhibiting activity
compounds
formula
Prior art date
Application number
BG105561A
Other languages
English (en)
Other versions
BG65126B1 (bg
Inventor
Beate Gutterer
Dieter Flockerzi
Herrmann Amschler
Gerhard Grundler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans - Peter Kley
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of BG105561A publication Critical patent/BG105561A/bg
Publication of BG65126B1 publication Critical patent/BG65126B1/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P11/06—Antiasthmatics
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

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Abstract

Изобретението се отнася до съединения с формула, в която значенията на R1, R2, R3, R4, R5, R6, R13,R20, R31 и R51 са посочени в описанието. Те са нови активни бронхиални терапевтици.
BG105561A 1999-01-15 2001-06-04 Фенилфенантридини с pde-iv инхибираща активност BG65126B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99100694 1999-01-15

Publications (2)

Publication Number Publication Date
BG105561A true BG105561A (bg) 2001-12-29
BG65126B1 BG65126B1 (bg) 2007-03-30

Family

ID=8237351

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105561A BG65126B1 (bg) 1999-01-15 2001-06-04 Фенилфенантридини с pde-iv инхибираща активност

Country Status (32)

Country Link
US (1) US6476025B1 (bg)
EP (2) EP1650193A3 (bg)
JP (1) JP4653314B2 (bg)
KR (1) KR100720906B1 (bg)
CN (1) CN1152864C (bg)
AT (1) ATE312081T1 (bg)
AU (1) AU774868B2 (bg)
BG (1) BG65126B1 (bg)
BR (1) BR0007527B1 (bg)
CA (1) CA2359440C (bg)
CY (1) CY1106436T1 (bg)
CZ (1) CZ300366B6 (bg)
DE (1) DE60024581T2 (bg)
DK (1) DK1147089T3 (bg)
EA (1) EA003780B1 (bg)
EE (1) EE05105B1 (bg)
ES (1) ES2254132T3 (bg)
HK (1) HK1040997B (bg)
HR (1) HRP20010578A2 (bg)
HU (1) HU227624B1 (bg)
ID (1) ID29070A (bg)
IL (2) IL144026A0 (bg)
NO (1) NO320182B1 (bg)
NZ (1) NZ512872A (bg)
PL (1) PL205670B1 (bg)
RS (1) RS50297B (bg)
SI (1) SI1147089T1 (bg)
SK (1) SK286946B6 (bg)
TR (2) TR200501553T2 (bg)
UA (1) UA69436C2 (bg)
WO (1) WO2000042020A1 (bg)
ZA (1) ZA200104864B (bg)

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