BG105373A - 2-фенилпиран-4-онови производни - Google Patents
2-фенилпиран-4-онови производниInfo
- Publication number
- BG105373A BG105373A BG105373A BG10537301A BG105373A BG 105373 A BG105373 A BG 105373A BG 105373 A BG105373 A BG 105373A BG 10537301 A BG10537301 A BG 10537301A BG 105373 A BG105373 A BG 105373A
- Authority
- BG
- Bulgaria
- Prior art keywords
- group
- alkyl
- trifluoromethyl
- hydroxycarbonyl
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретението се отнася до производни с формула, в която R1 означава алкилова или NR4R5 група, където R4 и R5 независимо един от друг означават водороден атом или алкилова група; R2 означава алкил, С3-7 циклоалкил, пиридил, тиенил, нафтил, тетрахидронафтил или инданилова или фенилова група, която може да е незаместена или заместена с един или повече халогенни атоми или алкил, трифлуорометил, хидрокси, алкокси, метилтио, амино, моно- или диалкиламино, хидроксиалкил или хидроксикарбонилови групи;R3 означава метил, хидроксиметил, алкоксиметил, С3-7 циклоалкоксиметил, бензилоксиметил, хидроксикарбонил, нитрил, трифлуорометил или дифлуорометилова група, или CH2-R6 група, в която R6 означава алкилова група и Х означава единична връзка, кислороден, серен атом или метиленова група. Изобретението се отнася също до фармацевтично приемливи соли на съединенията, до методи за тяхното получаване, както и до синтетични междинни съединения, използвани при методите, до фармацевтични състави, които ги съдържат, и до използването им в медицината.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9802011A ES2154561B1 (es) | 1998-09-25 | 1998-09-25 | Derivados de 2-fenilpiran-4-ona. |
| ES009900619A ES2168895A1 (es) | 1999-03-26 | 1999-03-26 | Derivados de 2-fenilpiran-4-ona. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG105373A true BG105373A (bg) | 2001-11-30 |
| BG65308B1 BG65308B1 (bg) | 2008-01-31 |
Family
ID=26155180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG105373A BG65308B1 (bg) | 1998-09-25 | 2001-03-22 | 2-фенилпиран-4-онови производни |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6518303B2 (bg) |
| EP (1) | EP1115716B1 (bg) |
| JP (1) | JP4717211B2 (bg) |
| KR (1) | KR100806684B1 (bg) |
| CN (1) | CN1202104C (bg) |
| AR (1) | AR021826A1 (bg) |
| AT (1) | ATE230405T1 (bg) |
| AU (1) | AU765653B2 (bg) |
| BG (1) | BG65308B1 (bg) |
| BR (1) | BR9913939A (bg) |
| CA (1) | CA2345069C (bg) |
| CO (1) | CO5140127A1 (bg) |
| CZ (1) | CZ300357B6 (bg) |
| DE (1) | DE69904738T2 (bg) |
| DK (1) | DK1115716T3 (bg) |
| EE (1) | EE04812B1 (bg) |
| EG (1) | EG23802A (bg) |
| ES (1) | ES2190252T3 (bg) |
| HK (1) | HK1034961A1 (bg) |
| HU (1) | HUP0104620A3 (bg) |
| ID (1) | ID28624A (bg) |
| IL (1) | IL142087A0 (bg) |
| MX (1) | MXPA01003069A (bg) |
| MY (1) | MY121793A (bg) |
| NO (1) | NO327987B1 (bg) |
| NZ (1) | NZ510625A (bg) |
| PE (1) | PE20001067A1 (bg) |
| PL (1) | PL346895A1 (bg) |
| RU (1) | RU2232158C2 (bg) |
| SI (1) | SI1115716T1 (bg) |
| SK (1) | SK286471B6 (bg) |
| TR (1) | TR200100852T2 (bg) |
| TW (1) | TW587079B (bg) |
| WO (1) | WO2000018753A1 (bg) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20011333A1 (es) | 2000-03-16 | 2002-01-16 | Almirall Prodesfarma Ag | Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2 |
| US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
| ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| ES2214130B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
| ES2214129B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 3-fenilfuran-2-onas. |
| US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
| WO2005009342A2 (en) * | 2003-07-16 | 2005-02-03 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
| US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
| US20050113409A1 (en) * | 2003-09-03 | 2005-05-26 | Pharmacia Corporation | Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith |
| US11096924B2 (en) | 2016-09-07 | 2021-08-24 | Trustees Of Tufts College | Combination therapies using immuno-dash inhibitors and PGE2 antagonists |
| WO2022195579A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US304728A (en) * | 1884-09-09 | Maubice hellwig | ||
| CH524614A (de) * | 1969-12-31 | 1972-06-30 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Imidazolderivaten |
| US3901908A (en) * | 1970-12-28 | 1975-08-26 | Ciba Geigy Corp | 2-alkyl- and 2-cycloalkyl-4,5-bis-phenyl-imidazoles |
| IL59748A (en) | 1979-04-05 | 1983-11-30 | Lilly Industries Ltd | 5-substituted pyranone derivatives,their production and pharmaceutical compositions containing them |
| US4304728A (en) * | 1979-04-05 | 1981-12-08 | Lilly Industries Limited | 6-Substituted pyranone compounds and their use as pharmaceuticals |
| JPS5834446B2 (ja) * | 1979-05-22 | 1983-07-27 | 三省製薬株式会社 | 消炎剤 |
| JPH0768234B2 (ja) * | 1989-12-14 | 1995-07-26 | 久光製薬株式会社 | コウジ酸エステル誘導体 |
| ES2079068T3 (es) * | 1990-06-29 | 1996-01-01 | Upjohn Co | 2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas. |
| JPH04173391A (ja) * | 1990-11-07 | 1992-06-22 | Sanyo Chem Ind Ltd | 感熱記録用増感剤および感熱記録用材料 |
| DE4103904C2 (de) * | 1991-02-08 | 1995-06-14 | Analyticon Ges Fuer Chemische | Neue Arzneimittel aus Gamma-Pyronen, Gamma-Pyridonen sowie Gamma-Thiopyronen |
| US6048850A (en) | 1992-09-22 | 2000-04-11 | Young; Donald A. | Method of inhibiting prostaglandin synthesis in a human host |
| EE9600044A (et) * | 1993-11-19 | 1996-10-15 | Parke, Davis & Company | Püranooni derivaadid kui proteaasi inhibiitorid ja viirusevastased toimeained |
| US5521213A (en) * | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| US5541204A (en) | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
| CZ313397A3 (cs) | 1995-04-04 | 1998-03-18 | Glaxo Group Limited | Imidazo/1,2a/pyridinové deriváty, způsob jejich výroby a farmaceutický prostředek s jejich obsahem |
| US6136839A (en) * | 1995-06-12 | 2000-10-24 | G. D. Searle & Co. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor |
| NZ504045A (en) * | 1997-11-19 | 2001-06-29 | Kowa Co | Pyridazine derivatives with inhibitory action against interleukin-1-beta production |
-
1999
- 1999-09-15 TW TW088115924A patent/TW587079B/zh not_active IP Right Cessation
- 1999-09-16 KR KR1020017003835A patent/KR100806684B1/ko not_active IP Right Cessation
- 1999-09-16 CN CNB998125709A patent/CN1202104C/zh not_active Expired - Fee Related
- 1999-09-16 JP JP2000572213A patent/JP4717211B2/ja not_active Expired - Fee Related
- 1999-09-16 AU AU60847/99A patent/AU765653B2/en not_active Ceased
- 1999-09-16 RU RU2001111323/04A patent/RU2232158C2/ru not_active IP Right Cessation
- 1999-09-16 SK SK370-2001A patent/SK286471B6/sk not_active IP Right Cessation
- 1999-09-16 EP EP99947372A patent/EP1115716B1/en not_active Expired - Lifetime
- 1999-09-16 ID IDW20010685D patent/ID28624A/id unknown
- 1999-09-16 AT AT99947372T patent/ATE230405T1/de active
- 1999-09-16 DE DE69904738T patent/DE69904738T2/de not_active Expired - Lifetime
- 1999-09-16 SI SI9930232T patent/SI1115716T1/xx unknown
- 1999-09-16 BR BR9913939-1A patent/BR9913939A/pt not_active Application Discontinuation
- 1999-09-16 CZ CZ20011058A patent/CZ300357B6/cs not_active IP Right Cessation
- 1999-09-16 EE EEP200100173A patent/EE04812B1/xx not_active IP Right Cessation
- 1999-09-16 MX MXPA01003069A patent/MXPA01003069A/es not_active IP Right Cessation
- 1999-09-16 HU HU0104620A patent/HUP0104620A3/hu unknown
- 1999-09-16 ES ES99947372T patent/ES2190252T3/es not_active Expired - Lifetime
- 1999-09-16 TR TR2001/00852T patent/TR200100852T2/xx unknown
- 1999-09-16 CA CA002345069A patent/CA2345069C/en not_active Expired - Fee Related
- 1999-09-16 DK DK99947372T patent/DK1115716T3/da active
- 1999-09-16 WO PCT/EP1999/006873 patent/WO2000018753A1/en active IP Right Grant
- 1999-09-16 NZ NZ510625A patent/NZ510625A/xx not_active IP Right Cessation
- 1999-09-16 IL IL14208799A patent/IL142087A0/xx unknown
- 1999-09-16 PL PL99346895A patent/PL346895A1/xx not_active Application Discontinuation
- 1999-09-21 MY MYPI99004101A patent/MY121793A/en unknown
- 1999-09-23 PE PE1999000966A patent/PE20001067A1/es not_active Application Discontinuation
- 1999-09-23 CO CO99060536A patent/CO5140127A1/es unknown
- 1999-09-24 AR ARP990104836A patent/AR021826A1/es active IP Right Grant
- 1999-09-25 EG EG118999A patent/EG23802A/xx active
-
2001
- 2001-03-16 US US09/809,645 patent/US6518303B2/en not_active Expired - Fee Related
- 2001-03-22 BG BG105373A patent/BG65308B1/bg unknown
- 2001-03-23 NO NO20011512A patent/NO327987B1/no not_active IP Right Cessation
- 2001-08-08 HK HK01105498A patent/HK1034961A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AP1687A (en) | Therapeutic biaryl derivatives. | |
| DK0590919T3 (da) | Terapeutiske midler mod Parkinsons sygdom | |
| BG105373A (bg) | 2-фенилпиран-4-онови производни | |
| MXPA04005990A (es) | Derivados de 5,6-diaril-pirazina-2-amida como antagonistas de cb1. | |
| HUP9901115A2 (hu) | 5-HT receptor antagonista indolszármazékok | |
| EP1248612A4 (en) | NEW SUBSTANCES AND COMPOUNDS AS PROTEASE INHIBITORS | |
| SG128491A1 (en) | Heterocyclic sulfonamide inhibitors of beta amyloid production | |
| DK0773930T3 (da) | Aromatiske aminoethere som midler til lindring af smerte | |
| MXPA03005822A (es) | Compuestos heterociclicos que tienen actividad antibacteriana, proceso para su preparacion y composiciones farmaceuticas que los contienen. | |
| TR200201638T2 (tr) | Yeni imidazo[1,3,5]triazinonlar ve kullanımları | |
| WO2003029243A3 (de) | 2-aryloxy-6-pyrazolyl-pyridine | |
| NZ514037A (en) | 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of CNS disorders | |
| WO2002048122A3 (en) | Benzamidine derivatives | |
| TW200420292A (en) | Benzofuran derivative | |
| DE69914880D1 (de) | Substituierte 5-(2,2difluor-1,3-benzodioxol-5-yl) cyclopentenopyridinderivate | |
| AR030410A1 (es) | Derivados de 2-fenilpiran-4-ona, proceso para obtener dichos derivados, composiciones farmaceuticas que comprenden los derivados mencionados y el uso de los mismos en la manufactura de medicamentos | |
| ECSP993153A (es) | Derivados de 2- fenilpiran -4-ona | |
| WO2003027077A1 (fr) | Derives de phenylpyridazine solubles dans l'eau et medicaments contenant ceux-ci | |
| ES2154561A1 (es) | Derivados de 2-fenilpiran-4-ona. | |
| DK0974353T3 (da) | Anvendelse af homocysteinderivater til behandling af bakterielle infektioner | |
| ATE500241T1 (de) | Phenyl- und pyridyl-piperidine mit tnf-wirkung | |
| ES2168895A1 (es) | Derivados de 2-fenilpiran-4-ona. | |
| TW200612968A (en) | Oligosaccharide derivatives containing with heterocycle |