[go: up one dir, main page]

BG102145A - Хетероциклилкарбоксамидни производни, метод за получаването и използването им като терапевтични средства - Google Patents

Хетероциклилкарбоксамидни производни, метод за получаването и използването им като терапевтични средства

Info

Publication number
BG102145A
BG102145A BG102145A BG10214597A BG102145A BG 102145 A BG102145 A BG 102145A BG 102145 A BG102145 A BG 102145A BG 10214597 A BG10214597 A BG 10214597A BG 102145 A BG102145 A BG 102145A
Authority
BG
Bulgaria
Prior art keywords
methylene
diseases
heterocyclylcarboxamide
optionally
derivatives
Prior art date
Application number
BG102145A
Other languages
English (en)
Other versions
BG62771B1 (bg
Inventor
Alan BIRCH
David Heal
Frank Kerrigan
Keith Martin
Patricia Needham
Bruce Sargent
Original Assignee
Knoll Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Gmbh filed Critical Knoll Gmbh
Publication of BG102145A publication Critical patent/BG102145A/bg
Publication of BG62771B1 publication Critical patent/BG62771B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

Хетероциклилкарбоксамидните производни намират приложение за лечение на заболявания на централната нервна система, например депресия, тревога, психози, като шизофрения, тардивна дискинезия, болестта на Паркинсон, пълнота, хипертензия, синдром на Tourette, сексуални нарушения, наркотична зависимост,злоупотреба с лекарства, наследствени заболявания, болестта на Алцхаймер, сенилна деменция, маниакално-натрапчиви състояния, панически страх, социални фобии, нарушения в храненето и безапетитие, кардио- и цереброваскуларни нарушения, независещ от инсулин диабетис мелитус, хипергликемия, запек, аритмия, нарушения на невроендокринната система, стрес, хипертрофия на простатата и спазми. Съединениятаимат формула, в която А е метилен или -О-, В е метилен или -О-, g има стойност 0, 1, 2, 3 или 4, R1е в даден случай наличен заместител, U - алкиленова верига, в даден случай заместена с една или повече алкилови групи, Q - дивалентна група, съдържаща азотни атоми и Т е групатаСО.НЕТ. Изобретението се отнася и до фармацевтично приемливите соли на посочените съединения.
BG102145A 1995-07-13 1997-12-23 Хетероциклилкарбоксамидни производни, метод за получаването и използването им като терапевтични средства BG62771B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9514380.6A GB9514380D0 (en) 1995-07-13 1995-07-13 Therapeutic agents
PCT/EP1996/002890 WO1997003071A1 (en) 1995-07-13 1996-07-02 Heterocyclylcarboxamide derivatives and their use as therapeutic agents

Publications (2)

Publication Number Publication Date
BG102145A true BG102145A (bg) 1998-11-30
BG62771B1 BG62771B1 (bg) 2000-07-31

Family

ID=10777626

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102145A BG62771B1 (bg) 1995-07-13 1997-12-23 Хетероциклилкарбоксамидни производни, метод за получаването и използването им като терапевтични средства

Country Status (26)

Country Link
US (1) US5935973A (bg)
EP (1) EP0839145B1 (bg)
JP (1) JPH11508599A (bg)
KR (1) KR19990028918A (bg)
CN (1) CN1071755C (bg)
AT (1) ATE253573T1 (bg)
AU (1) AU708890B2 (bg)
BG (1) BG62771B1 (bg)
BR (1) BR9609506A (bg)
CA (1) CA2223472A1 (bg)
CZ (1) CZ388497A3 (bg)
DE (1) DE69630604T2 (bg)
GB (1) GB9514380D0 (bg)
HR (1) HRP960348A2 (bg)
HU (1) HUP9901485A3 (bg)
IL (1) IL122540A (bg)
MX (1) MX9800084A (bg)
NO (1) NO980129L (bg)
NZ (1) NZ313164A (bg)
PL (1) PL324529A1 (bg)
RU (1) RU2169147C2 (bg)
SK (1) SK2498A3 (bg)
TR (1) TR199800041T1 (bg)
TW (1) TW454006B (bg)
WO (1) WO1997003071A1 (bg)
ZA (1) ZA965921B (bg)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9811879D0 (en) * 1998-06-03 1998-07-29 Knoll Ag Therapeutic agents
GB9915616D0 (en) * 1999-07-05 1999-09-01 Knoll Ag Therapeutic agents
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
US6608058B2 (en) 2000-04-17 2003-08-19 Dong Wha Pharm. Ind. Co., Ltd. 6-methylnicotinamide derivatives as antiviral agents
JP2004513915A (ja) * 2000-11-14 2004-05-13 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 複合的な選択的ドーパミンｄ２レセプターアンタゴニストおよび５−ｈｔ１ａレセプターアゴニストの新規な使用
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
JP2004538289A (ja) * 2001-07-26 2004-12-24 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング ２−［５−（４−フルオロフェニル）−３−ピリジルメチルアミノメチル］−クロマンおよびその生理学的に許容し得る塩の新規な使用
EP1651612B9 (en) 2003-07-22 2012-09-05 Astex Therapeutics Limited 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
JP2007523202A (ja) * 2004-02-24 2007-08-16 ビオアクソン・テラプティーク・インコーポレーテッド ４置換ピペリジン誘導体
JP4604583B2 (ja) * 2004-07-20 2011-01-05 ダイソー株式会社 １−アミド−３−（２−ヒドロキシフェノキシ）−２−プロパノール誘導体、ならびに２−アミドメチル−１，４−ベンゾジオキサン誘導体の製造法
JP5475234B2 (ja) 2005-01-21 2014-04-16 アステックス・セラピューティクス・リミテッド 医薬化合物
US20090036435A1 (en) 2005-01-21 2009-02-05 Astex Therapeutics Limited Pharmaceutical Compounds
TWI457122B (zh) * 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
EP2271634B1 (en) * 2008-04-29 2014-02-12 Integrative Research Laboratories Sweden AB Modulators of dopamine neurotransmission
EP2858987B1 (en) * 2012-06-11 2018-04-25 Bristol-Myers Squibb Company Phosphoramidic acid prodrugs of 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8302622D0 (en) * 1983-01-31 1983-03-02 Celltech Ltd Immunoassay
EP0200960A1 (en) * 1985-05-08 1986-11-12 Abbott Laboratories Total estriol fluorescence polarization immunoassay
JPH05505599A (ja) * 1990-03-15 1993-08-19 ジ・アップジョン・カンパニー 治療上有用な複素環インドール化合物類
US5240943A (en) * 1991-12-19 1993-08-31 G. D. Searle & Co. Benzopyran class iii antiarrhythmic agents
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
IL122540A (en) 2001-10-31
BR9609506A (pt) 1999-06-01
NO980129D0 (no) 1998-01-12
HRP960348A2 (en) 1998-04-30
PL324529A1 (en) 1998-06-08
EP0839145B1 (en) 2003-11-05
KR19990028918A (ko) 1999-04-15
BG62771B1 (bg) 2000-07-31
MX9800084A (es) 1998-03-29
AU6517296A (en) 1997-02-10
SK2498A3 (en) 1998-09-09
NZ313164A (en) 1999-07-29
CN1071755C (zh) 2001-09-26
HUP9901485A2 (en) 2000-07-28
US5935973A (en) 1999-08-10
CN1190967A (zh) 1998-08-19
GB9514380D0 (en) 1995-09-13
HUP9901485A3 (en) 2001-03-28
AU708890B2 (en) 1999-08-12
IL122540A0 (en) 1998-06-15
ATE253573T1 (de) 2003-11-15
NO980129L (no) 1998-01-12
CA2223472A1 (en) 1997-01-30
TW454006B (en) 2001-09-11
ZA965921B (en) 1998-01-12
DE69630604T2 (de) 2004-09-23
JPH11508599A (ja) 1999-07-27
DE69630604D1 (de) 2003-12-11
WO1997003071A1 (en) 1997-01-30
CZ388497A3 (cs) 1998-06-17
TR199800041T1 (xx) 1998-05-21
EP0839145A1 (en) 1998-05-06
RU2169147C2 (ru) 2001-06-20

Similar Documents

Publication Publication Date Title
BG102145A (bg) Хетероциклилкарбоксамидни производни, метод за получаването и използването им като терапевтични средства
ATE210652T1 (de) Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
DE69907210D1 (de) Glucocorticoid- und thyroidhormonrezeptor-liganden zur behandlung von stoffwechselkrankheiten
DK0723540T3 (da) Tricykliske amid- og urinstofderivater til inhibering af funktion af G-protein og til behandling af proliferative sygdomme
NO974608L (no) Nye mellomprodukter og fremgangsmåte for fremstilling av camptothecinderivater (CPT-11) og beslektede forbindelser
ATE205475T1 (de) Verfahren zur herstellung von azetidinonen
BR9407413A (pt) Compostos uso dos mesmos e processo para a sua preparação composições farmacêuticas e processo para o tratamento de doenças
Jones et al. A new route to homochiral piperidines
PT87294A (pt) Process for the preparation of 17beta-(cyclopropylamino)-androst-5-en-3beta-ol and related compounds useful as c17-20 lyase inhibitors and of pharmaceutical compositions containing the same
FI904035A0 (fi) Menetelmä valmistaa terapeuttisesti aktiivisia 4-substituoituja 17 -(syklopropyyliamino)androst-5-eenijohdannaisia, jotka ovat hyödyllisiä C17-20-lyaasi-inhibiittoreina
UA49801C2 (uk) Похідні тропан-2-альдоксиму, спосіб їх отримання, фармацевтична композиція, спосіб лікування
DE69404306D1 (de) Verfahren zur herstellung und optischen auflösung von 2-phenyl-3-aminopiperidine
HUP0003273A2 (hu) Eljárás izoxazolidin-dion-származékok előállítására
Berg et al. The first colchicine analogue with an eight membered B-ring. Structure, optical resolution and inhibition of microtubule assembly
ATE36318T1 (de) Verfahren zur herstellung von azetidinderivaten und zwischenprodukte.
ATE159021T1 (de) Verfahren zur herstellung von penem derivaten und zwischenprodukte zu dieser herstellung
DE69619868D1 (de) Piperazinylalkylthiopyrimidin derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu deren herstellung
Bringmann A first biosynthetic proposal for the in vivo formation of naturally occurring diazepam-like 1, 4-benzodiazepines
NO975961L (no) Fremgangsmåte for fremstilling av 1-(3-trialkylsilylfenyl)-2,2,2-trifluorometyl-ethanonderivater