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BG102064A - Състав за лечение на увреждания на зрителния нерви ретината - Google Patents

Състав за лечение на увреждания на зрителния нерви ретината

Info

Publication number
BG102064A
BG102064A BG102064A BG10206497A BG102064A BG 102064 A BG102064 A BG 102064A BG 102064 A BG102064 A BG 102064A BG 10206497 A BG10206497 A BG 10206497A BG 102064 A BG102064 A BG 102064A
Authority
BG
Bulgaria
Prior art keywords
increasing
blood circulation
retinal blood
retinal
bloodcirculation
Prior art date
Application number
BG102064A
Other languages
English (en)
Other versions
BG63148B1 (bg
Inventor
William Sponsel
Alon Harris
Original Assignee
Advanced Research And Technology Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Research And Technology Institute filed Critical Advanced Research And Technology Institute
Publication of BG102064A publication Critical patent/BG102064A/bg
Publication of BG63148B1 publication Critical patent/BG63148B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретението се отнася до състав, съдържащ ефективно количество инхибитор на карбонат дехидрогеназа и фармацевтично поносим носител за локално прилагане в окото, и до неговото използване за повишаване скоростта на ретиналния кръвен поток. Инхибиторът е избран от дорзоламид, ацетазоламид, метазоламид, по-специално дорзоламид и е в количество от 0,01 до 5% и 0,5 - 2%-ен разтвор в офталмологично приемлив носител.
BG102064A 1995-05-22 1997-11-21 Състав за лечение на увреждания на зрителния нерви ретината BG63148B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/445,839 US5789435A (en) 1995-05-22 1995-05-22 Method to increase retinal and optical nerve head blood flow velocity in order to preserve sight
PCT/US1996/007225 WO1996037203A1 (en) 1995-05-22 1996-05-17 Method to increase retinal blood flow

Publications (2)

Publication Number Publication Date
BG102064A true BG102064A (bg) 1998-07-31
BG63148B1 BG63148B1 (bg) 2001-05-31

Family

ID=23770397

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102064A BG63148B1 (bg) 1995-05-22 1997-11-21 Състав за лечение на увреждания на зрителния нерви ретината

Country Status (21)

Country Link
US (1) US5789435A (bg)
EP (1) EP0833632A1 (bg)
JP (1) JPH11503462A (bg)
KR (1) KR19990021853A (bg)
CN (1) CN1186019C (bg)
AU (1) AU703301B2 (bg)
BG (1) BG63148B1 (bg)
BR (1) BR9609297A (bg)
CA (1) CA2218549C (bg)
CZ (1) CZ289224B6 (bg)
EE (1) EE9700361A (bg)
HK (1) HK1020166A1 (bg)
HU (1) HUP9802553A3 (bg)
IS (1) IS4611A (bg)
NO (1) NO318600B1 (bg)
NZ (1) NZ308016A (bg)
RU (1) RU2181045C2 (bg)
SK (1) SK283960B6 (bg)
TR (1) TR199701406T1 (bg)
UA (1) UA48178C2 (bg)
WO (1) WO1996037203A1 (bg)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506461A (ja) * 1997-06-26 2002-02-26 メルク エンド カンパニー インコーポレーテッド 網膜及び視神経の健康の最適化方法
US6126037A (en) * 1997-09-09 2000-10-03 Merck & Co., Inc. Flow control orifice
AU1801299A (en) * 1997-12-12 1999-07-05 Alcon Laboratories, Inc. Use of brinzolamide for the manufacture of a medicament for improving ocular blood flow
DE69928771T2 (de) * 1998-01-23 2006-09-07 Einar Stefansson Carbonische anhydrase inhibitor zur steigerung des sauerstoffdrucks im sehnerv und retina
WO1999044603A1 (en) * 1998-03-06 1999-09-10 Sponsel William E Composition and method for treating macular disorders
WO2004073708A1 (en) 1998-12-17 2004-09-02 Dean Thomas R Brinzolamide and brimonidine for treating ocular conditions
JP4717996B2 (ja) * 2000-10-11 2011-07-06 サーパス工業株式会社 容器及びそれに用いるプラグ
US20040046934A1 (en) * 2002-02-14 2004-03-11 Board Of Regents, The University Of Texas System Oculokinetic offset acuity testing
US20040242457A1 (en) * 2003-05-27 2004-12-02 Ashby Charles R. Use of anti-glaucoma drugs to treat visual defects associated with the use of a GABAergic agent
GB2413282B (en) * 2004-04-23 2009-01-14 Henderson Morley Plc DNA Viral Infections
US20060073172A1 (en) * 2004-10-01 2006-04-06 Schneider L W Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure
MX2007011165A (es) * 2007-09-12 2009-03-11 Arturo Jimenez Bayardo Composición farmacéutica estable de timolol, dorzolamida y brimonidina.
US10363245B2 (en) 2017-02-22 2019-07-30 The Board Of Regents Of The University Of Texas System Methods for treating CNS lesions
AU2018374286B2 (en) 2017-12-03 2024-02-08 Natureworks Llc Polylactic resin compositions for paperboard coating and paperboard coating processes using the compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416890A (en) * 1981-07-13 1983-11-22 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4386098A (en) * 1981-11-03 1983-05-31 Merck & Co., Inc. 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4426388A (en) * 1982-04-02 1984-01-17 Merck & Co., Inc. 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
GB2203039B (en) * 1987-03-02 1990-10-24 American Cyanamid Co Stable ophthalmic preparations containing acetazolamide
US5494901A (en) * 1993-01-05 1996-02-27 Javitt; Jonathan C. Topical compositions for the eye comprising a β-cyclodextrin derivative and a therapeutic agent

Also Published As

Publication number Publication date
EE9700361A (et) 1998-06-15
NZ308016A (en) 2000-09-29
BR9609297A (pt) 1999-08-17
CN1186019C (zh) 2005-01-26
HK1020166A1 (en) 2000-03-31
SK283960B6 (sk) 2004-06-08
EP0833632A1 (en) 1998-04-08
AU703301B2 (en) 1999-03-25
BG63148B1 (bg) 2001-05-31
WO1996037203A1 (en) 1996-11-28
NO975330D0 (no) 1997-11-20
CN1199336A (zh) 1998-11-18
EP0833632A4 (bg) 1998-05-20
NO318600B1 (no) 2005-04-18
NO975330L (no) 1998-01-07
CZ289224B6 (cs) 2001-12-12
JPH11503462A (ja) 1999-03-26
RU2181045C2 (ru) 2002-04-10
HUP9802553A2 (hu) 1999-04-28
SK153597A3 (en) 1998-07-08
HUP9802553A3 (en) 2002-01-28
UA48178C2 (uk) 2002-08-15
CA2218549C (en) 2005-09-20
MX9709063A (es) 1998-10-31
IS4611A (is) 1997-11-10
CA2218549A1 (en) 1996-11-28
TR199701406T1 (xx) 1998-03-21
AU5754096A (en) 1996-12-11
KR19990021853A (ko) 1999-03-25
CZ369497A3 (cs) 1998-06-17
US5789435A (en) 1998-08-04

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