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BE903912A - Nouvelles alpha-acylaminoergolines, leur preparation, leur utilisation comme medicaments et les compositions pharmaceutiques les contenant. - Google Patents

Nouvelles alpha-acylaminoergolines, leur preparation, leur utilisation comme medicaments et les compositions pharmaceutiques les contenant.

Info

Publication number
BE903912A
BE903912A BE1/011403A BE1011403A BE903912A BE 903912 A BE903912 A BE 903912A BE 1/011403 A BE1/011403 A BE 1/011403A BE 1011403 A BE1011403 A BE 1011403A BE 903912 A BE903912 A BE 903912A
Authority
BE
Belgium
Prior art keywords
medicaments
acylaminoergolins
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
BE1/011403A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE903912A publication Critical patent/BE903912A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Les 8 alpha-acylaminoergolines de formule (I) dans laquelle R1 représente l'hydrogène ou un groupe alkyle, R2 représente l'hydrogène, le chlore, le brome ou un groupe méthyle, R3 représente un groupe alkyle, alcényle et R4 représente un groupe alkyle, cycloalkyle, adamantyle, phényle éventuellement substitué ou phényle condensé à un hétérocycle non aromatique à 5 ou 5 chainons comportant 1 ou 2 hétéroatomes choisis parmi l'oxygène et/ou le soufre. Ces composés peuvent etre utilisés comme médicaments, notamment comme agents neuroleptiques et agents inhibiteurs de la sécrétion de la prolactine.
BE1/011403A 1984-12-24 1985-12-20 Nouvelles alpha-acylaminoergolines, leur preparation, leur utilisation comme medicaments et les compositions pharmaceutiques les contenant. BE903912A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3447383 1984-12-24

Publications (1)

Publication Number Publication Date
BE903912A true BE903912A (fr) 1986-06-20

Family

ID=6253885

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/011403A BE903912A (fr) 1984-12-24 1985-12-20 Nouvelles alpha-acylaminoergolines, leur preparation, leur utilisation comme medicaments et les compositions pharmaceutiques les contenant.

Country Status (22)

Country Link
US (1) US4791115A (fr)
JP (1) JPS61158980A (fr)
AT (1) AT387776B (fr)
AU (1) AU589933B2 (fr)
BE (1) BE903912A (fr)
CH (1) CH666035A5 (fr)
DK (1) DK606385A (fr)
ES (1) ES8800220A1 (fr)
FI (1) FI855131A (fr)
FR (1) FR2575159B1 (fr)
GB (1) GB2169291B (fr)
GR (1) GR853098B (fr)
HU (1) HU195810B (fr)
IL (1) IL77426A (fr)
IT (1) IT1200163B (fr)
LU (1) LU86226A1 (fr)
NL (1) NL8503426A (fr)
NZ (1) NZ214699A (fr)
PH (1) PH23343A (fr)
PT (1) PT81759B (fr)
SE (1) SE8506125L (fr)
ZA (1) ZA859843B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
JP2779447B2 (ja) * 1988-03-20 1998-07-23 財団法人阪大微生物病研究会 弱毒マレック病ウイルス・ベクターを用いる組換え遺伝子作成法、及び該ウイルスの組換え体
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
CH415658A (de) * 1962-06-18 1966-06-30 Sandoz Ag Verfahren zur Herstellung von neuen Urethanen
GB1517972A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-cyanomethylergoline i
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
DE3063869D1 (en) * 1979-06-13 1983-07-28 Schering Ag (ergolin-yl)-n', n'-diethyl urea derivatives, their preparation and pharmaceutical compositions containing them
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3135305C2 (de) * 1981-09-03 1983-07-21 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 8-Ergolinyl-harnstoffen
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
US4448392A (en) * 1982-01-25 1984-05-15 Auto Specialties Manufacturing Company Thread stop for a screw jack

Also Published As

Publication number Publication date
FR2575159A1 (fr) 1986-06-27
LU86226A1 (fr) 1986-06-25
ES550351A0 (es) 1987-11-01
SE8506125D0 (sv) 1985-12-23
IL77426A (en) 1989-07-31
PH23343A (en) 1989-07-14
PT81759A (en) 1986-01-02
AU5156185A (en) 1986-07-03
NL8503426A (nl) 1986-07-16
ZA859843B (en) 1987-08-26
SE8506125L (sv) 1986-06-25
JPS61158980A (ja) 1986-07-18
IT1200163B (it) 1989-01-05
ATA372885A (de) 1988-08-15
NZ214699A (en) 1989-02-24
AT387776B (de) 1989-03-10
HUT40652A (en) 1987-01-28
GB2169291B (en) 1988-09-21
CH666035A5 (de) 1988-06-30
GB2169291A (en) 1986-07-09
DK606385D0 (da) 1985-12-23
IT8548964A0 (it) 1985-12-20
US4791115A (en) 1988-12-13
PT81759B (en) 1987-10-06
DK606385A (da) 1986-06-25
GR853098B (fr) 1986-04-18
HU195810B (en) 1988-07-28
GB8531420D0 (en) 1986-02-05
ES8800220A1 (es) 1987-11-01
FI855131A (fi) 1986-06-25
FI855131A0 (fi) 1985-12-20
FR2575159B1 (fr) 1988-09-09
AU589933B2 (en) 1989-10-26

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SANDOZ S.A.

Effective date: 19901231