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BE903376A - VITAMIN D DERIVATIVES AND PRECURSORS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME - Google Patents

VITAMIN D DERIVATIVES AND PRECURSORS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Info

Publication number
BE903376A
BE903376A BE0/215682A BE215682A BE903376A BE 903376 A BE903376 A BE 903376A BE 0/215682 A BE0/215682 A BE 0/215682A BE 215682 A BE215682 A BE 215682A BE 903376 A BE903376 A BE 903376A
Authority
BE
Belgium
Prior art keywords
vitamin
precursors
derivatives
pharmaceutical compositions
compositions containing
Prior art date
Application number
BE0/215682A
Other languages
French (fr)
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BE903376A publication Critical patent/BE903376A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Des procédés pour les préparer et de nouveaux composés intermédiaires utiles à cette fin de formule (I) où R1, R2 et R3 représentent un atome d'hydrogène ou radical acyle en C 1-4 ou benzoyle et R4 et R5 représentent chacun un atome d'hydrogène ou pris ensemble forment une liaison carbone-carbone. Ces composés ont une activité vitaminoide D semblable à celle de 1a 1 alph, 25-dihydroxyvitamine D3.Processes for preparing them and new intermediate compounds useful for this purpose of formula (I) where R1, R2 and R3 represent a hydrogen atom or C 1-4 acyl or benzoyl radical and R4 and R5 each represent a d atom hydrogen or taken together form a carbon-carbon bond. These compounds have a vitamin D activity similar to that of 1 alph, 25-dihydroxyvitamin D3.

BE0/215682A 1984-10-04 1985-10-04 VITAMIN D DERIVATIVES AND PRECURSORS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME BE903376A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65754984A 1984-10-04 1984-10-04

Publications (1)

Publication Number Publication Date
BE903376A true BE903376A (en) 1986-02-03

Family

ID=24637652

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215682A BE903376A (en) 1984-10-04 1985-10-04 VITAMIN D DERIVATIVES AND PRECURSORS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Country Status (13)

Country Link
EP (1) EP0197949A1 (en)
JP (3) JPS62500301A (en)
AU (2) AU582789B2 (en)
BE (1) BE903376A (en)
CH (1) CH672920A5 (en)
DE (2) DE3590488C2 (en)
DK (5) DK154290C (en)
FR (1) FR2571369B1 (en)
GB (2) GB2167070B (en)
IE (1) IE58104B1 (en)
IT (1) IT1190401B (en)
NL (1) NL8520265A (en)
WO (1) WO1986002078A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2711161B2 (en) * 1988-04-21 1998-02-10 レオ・ファーマシューティカル・プロダクツ・リミテッド・エイ／エス（レーベンス・ケミスケ・ファブリック・プロデュクチオンスアクチーセルスカブ） Novel vitamin D analog
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
KR940003360B1 (en) * 1988-04-29 1994-04-21 위스콘신 알럼나이 리써취 파운데이션 1α-hydroxyvitamin D Homolog with Unsaturated Side Chains
US5063221A (en) * 1989-04-05 1991-11-05 Chugai Seiyaku Kabushiki Kaisha Treatment for hyperparathyroidism with use of vitamin d derivatives
DE3933034A1 (en) * 1989-10-02 1991-04-11 Schering Ag 24-HOMO-VITAMIN-D DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5891865A (en) * 1996-10-04 1999-04-06 Wisconsin Alumni Research Foundation Treatment of arthritic disease induced by infectious agents
WO2006051106A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
AU527805B2 (en) * 1978-07-27 1983-03-24 Research Institute For Medicine And Chemistry Inc. 1alpha, 1beta dihydroxy steroid-5-enes
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
DE3448360C2 (en) * 1983-05-09 1991-10-02 Wisconsin Alumni Res Found

Also Published As

Publication number Publication date
IT1190401B (en) 1988-02-16
AU4776185A (en) 1986-04-17
JPH05178887A (en) 1993-07-20
GB8524479D0 (en) 1985-11-06
DK15290D0 (en) 1990-01-19
DK158990C (en) 1991-01-21
DK177489A (en) 1989-04-13
GB2188932A (en) 1987-10-14
DK15390A (en) 1990-01-19
DK158990B (en) 1990-08-13
DK15290A (en) 1990-01-19
WO1986002078A1 (en) 1986-04-10
DE3590488T (en) 1986-10-09
JPH0635475B2 (en) 1994-05-11
GB8709579D0 (en) 1987-05-28
DK158989B (en) 1990-08-13
AU605007B2 (en) 1991-01-03
JPH0569103B2 (en) 1993-09-30
JPH0689022B2 (en) 1994-11-09
DK159389B (en) 1990-10-08
JPH05222089A (en) 1993-08-31
FR2571369A1 (en) 1986-04-11
DK158989C (en) 1991-01-21
GB2167070B (en) 1988-09-01
DK15390D0 (en) 1990-01-19
GB2188932B (en) 1988-09-01
DK158991B (en) 1990-08-13
DK154290B (en) 1988-10-31
DK158991C (en) 1991-01-21
DE3590488C2 (en) 1992-10-01
NL8520265A (en) 1986-09-01
IE58104B1 (en) 1993-06-30
JPS62500301A (en) 1987-02-05
DK260086D0 (en) 1986-06-03
DK111188A (en) 1988-03-02
EP0197949A1 (en) 1986-10-22
GB2167070A (en) 1986-05-21
DK159389C (en) 1991-03-11
DK154290C (en) 1989-03-28
IE852443L (en) 1986-04-04
CH672920A5 (en) 1990-01-15
IT8522359A0 (en) 1985-10-04
AU2761488A (en) 1989-06-08
DK177489D0 (en) 1989-04-13
AU582789B2 (en) 1989-04-13
DK260086A (en) 1986-06-03
DK111188D0 (en) 1988-03-02
FR2571369B1 (en) 1987-12-04

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION

Effective date: 19981031