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BE899875A - 1-PHENOXY-3-HYDROXYINDOLYLALKYLAMINO-3-PROPANOLS AND THEIR PREPARATION. - Google Patents

1-PHENOXY-3-HYDROXYINDOLYLALKYLAMINO-3-PROPANOLS AND THEIR PREPARATION.

Info

Publication number
BE899875A
BE899875A BE0/213109A BE213109A BE899875A BE 899875 A BE899875 A BE 899875A BE 0/213109 A BE0/213109 A BE 0/213109A BE 213109 A BE213109 A BE 213109A BE 899875 A BE899875 A BE 899875A
Authority
BE
Belgium
Prior art keywords
hydrogen
alkyl
hydroxyindolylalkylamino
propanols
phenoxy
Prior art date
Application number
BE0/213109A
Other languages
French (fr)
Inventor
W E Kreighbaum
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE899875A publication Critical patent/BE899875A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composé ayant la formule (I) et ses sels d'addition d'acides, dans laquelle : l'un des radicaux R1 et R2 représente un hydrogène et l'autre représente un hydrogène ou un alkyle en C1 à C4; R3 et R4 indépendamment, sont choisis entre hydrogène ou alkyle en C1-C4; R5 représente halogène, hydrogène, hydroxy ou alkyle en C1-C4; la chaine latérale phénoxypropanolaminoalkyle est attachée au cycle indolique soit en position 2, soit en position 3; et le groupe substituant hydroxyle occupe soit les positions 4,5,6 ou 7 du cycle de l'indole.A compound having the formula (I) and its acid addition salts, wherein: one of the radicals R1 and R2 represents hydrogen and the other represents hydrogen or C1-C4 alkyl; R3 and R4 independently, are chosen between hydrogen or C1-C4 alkyl; R5 represents halogen, hydrogen, hydroxy or C1-C4 alkyl; the phenoxypropanolaminoalkyl side chain is attached to the indolic ring either in position 2 or in position 3; and the hydroxyl substituent group occupies either the 4,5,6 or 7 positions of the indole ring.

BE0/213109A 1983-06-10 1984-06-08 1-PHENOXY-3-HYDROXYINDOLYLALKYLAMINO-3-PROPANOLS AND THEIR PREPARATION. BE899875A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50290183A 1983-06-10 1983-06-10

Publications (1)

Publication Number Publication Date
BE899875A true BE899875A (en) 1984-12-10

Family

ID=23999880

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213109A BE899875A (en) 1983-06-10 1984-06-08 1-PHENOXY-3-HYDROXYINDOLYLALKYLAMINO-3-PROPANOLS AND THEIR PREPARATION.

Country Status (29)

Country Link
JP (1) JPS608262A (en)
KR (1) KR900005021B1 (en)
AT (1) AT381492B (en)
AU (1) AU569303B2 (en)
BE (1) BE899875A (en)
CA (1) CA1217496A (en)
CH (1) CH662561A5 (en)
CY (1) CY1518A (en)
DE (1) DE3421252A1 (en)
DK (1) DK162089C (en)
ES (1) ES533185A0 (en)
FI (1) FI78291C (en)
FR (1) FR2549054B1 (en)
GB (1) GB2141121B (en)
GR (1) GR82208B (en)
HK (1) HK14690A (en)
HU (1) HU191670B (en)
IE (1) IE57682B1 (en)
IL (1) IL72008A (en)
IT (1) IT1206705B (en)
LU (1) LU85410A1 (en)
MY (1) MY102077A (en)
NL (1) NL8401840A (en)
NO (1) NO164471C (en)
NZ (1) NZ208337A (en)
SE (1) SE455865B (en)
SG (1) SG1090G (en)
YU (1) YU44873B (en)
ZA (1) ZA844277B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601008B1 (en) * 1986-07-03 1990-03-30 Sanofi Sa PROCESS FOR THE STEREOSPECIFIC SYNTHESIS OF INDOLE DERIVATIVES
KR101986648B1 (en) 2018-04-06 2019-06-07 (유)로뎀건설 Excavating device for steel pipe access hole

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB962793A (en) * 1959-07-13 1964-07-01 Philips Nv Improvements in or relating to pharmacologically active compounds being substituted tryptamines
NL300886A (en) * 1962-11-23
US4314943A (en) * 1977-07-13 1982-02-09 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
CA1116598A (en) * 1977-07-13 1982-01-19 William T. Comer 3-indolyl-tertiary butylaminopropanols
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
FR2463765A1 (en) * 1979-08-17 1981-02-27 Clin Midy NEW ACTIVE INDOLE DERIVATIVES ON THE CARDIOVASCULAR SYSTEM

Also Published As

Publication number Publication date
FI842316A0 (en) 1984-06-07
ZA844277B (en) 1985-03-27
SE8403112L (en) 1984-12-11
SG1090G (en) 1990-07-06
CA1217496A (en) 1987-02-03
NL8401840A (en) 1985-01-02
HK14690A (en) 1990-03-02
JPH0587503B2 (en) 1993-12-16
NO164471B (en) 1990-07-02
FR2549054B1 (en) 1988-03-04
GB2141121B (en) 1987-01-07
NO842279L (en) 1984-12-11
DE3421252A1 (en) 1984-12-13
NZ208337A (en) 1988-10-28
ES8507490A1 (en) 1985-09-16
FI78291C (en) 1989-07-10
LU85410A1 (en) 1985-03-26
AU2923884A (en) 1984-12-13
DK162089B (en) 1991-09-16
IL72008A0 (en) 1984-10-31
AT381492B (en) 1986-10-27
KR850000396A (en) 1985-02-27
IE57682B1 (en) 1993-02-24
HUT34445A (en) 1985-03-28
DK284184A (en) 1984-12-11
AU569303B2 (en) 1988-01-28
ATA186784A (en) 1986-03-15
HU191670B (en) 1987-03-30
MY102077A (en) 1992-03-31
KR900005021B1 (en) 1990-07-18
FR2549054A1 (en) 1985-01-18
SE8403112D0 (en) 1984-06-08
GR82208B (en) 1984-12-13
FI78291B (en) 1989-03-31
JPS608262A (en) 1985-01-17
ES533185A0 (en) 1985-09-16
IL72008A (en) 1988-05-31
YU44873B (en) 1991-04-30
DK162089C (en) 1992-02-24
GB2141121A (en) 1984-12-12
IT1206705B (en) 1989-04-27
NO164471C (en) 1990-10-10
SE455865B (en) 1988-08-15
IE841441L (en) 1984-12-10
CH662561A5 (en) 1987-10-15
GB8414652D0 (en) 1984-07-11
CY1518A (en) 1990-11-16
IT8421330A0 (en) 1984-06-08
DK284184D0 (en) 1984-06-08
YU99784A (en) 1986-10-31
FI842316L (en) 1984-12-11

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Legal Events

Date Code Title Description
RE Patent lapsed

Effective date: 20030630