BE875652A - Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine - Google Patents

Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine

Info

Publication number: BE875652A
Authority: BE; Belgium
Prior art keywords: decarboxhydrazide; vincaleucoblastine; desacetyl; tumor; derivatives
Prior art date: 1978-04-20

Application number

BE1/9358A

Other languages

English (en)

French (fr)

Inventor

G J Cullinan

K Gerzon

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-18

Publication date

1979-10-18

1979-04-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1979-10-18 Publication of BE875652A publication Critical patent/BE875652A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

BE1/9358A 1978-04-20 1979-04-18 Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine BE875652A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
BE875652A true BE875652A (fr)	1979-10-18

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE1/9358A BE875652A (fr)	1978-04-20	1979-04-18	Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine

Country Status (32)

Country	Link
US (1)	US4166810A (bg)
EP (1)	EP0005051B1 (bg)
JP (1)	JPS54141798A (bg)
AR (1)	AR228940A1 (bg)
AT (1)	AT369010B (bg)
AU (1)	AU527109B2 (bg)
BE (1)	BE875652A (bg)
BG (3)	BG33296A3 (bg)
CA (1)	CA1097629A (bg)
CH (1)	CH643269A5 (bg)
CS (3)	CS218583B2 (bg)
DD (1)	DD143075A5 (bg)
DE (1)	DE2964130D1 (bg)
DK (1)	DK147484C (bg)
EG (1)	EG14867A (bg)
ES (2)	ES479754A1 (bg)
FI (1)	FI791286A (bg)
FR (1)	FR2423495A1 (bg)
GB (1)	GB2019396B (bg)
GR (1)	GR69987B (bg)
HU (1)	HU181431B (bg)
IE (1)	IE48213B1 (bg)
IL (1)	IL57168A (bg)
LU (1)	LU81166A1 (bg)
NZ (1)	NZ190213A (bg)
PH (1)	PH14163A (bg)
PL (3)	PL125470B1 (bg)
PT (1)	PT69496A (bg)
RO (3)	RO81037A (bg)
SU (3)	SU893135A3 (bg)
YU (1)	YU93179A (bg)
ZA (1)	ZA791856B (bg)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DE3483336D1 (de) *	1983-03-30	1990-11-08	Lilly Industries Ltd	Vincaleukoblastin-derivate.
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
DE60231868D1 (de) *	2001-04-24	2009-05-20	Purdue Research Foundation	Folat-mimetika und deren folatrezeptorbindende konjugate
EP2060272A3 (en) *	2002-05-15	2009-05-27	Endocyte, Inc.	Vitamin-mitomycin conjugates
NZ541846A (en)	2003-01-27	2008-12-24	Endocyte Inc	Vitamin receptor binding drug delivery conjugates
US8288557B2 (en)	2004-07-23	2012-10-16	Endocyte, Inc.	Bivalent linkers and conjugates thereof
JP5289935B2 (ja) *	2005-03-16	2013-09-11	エンドサイト，インコーポレイテッド	プテロイン酸およびその結合体の合成と精製
KR20130113543A (ko) *	2005-08-19	2013-10-15	엔도사이트, 인코포레이티드	복수-약제 리간드 공액체
US20080280937A1 (en) *	2005-08-19	2008-11-13	Christopher Paul Leamon	Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives
US20100087370A1 (en) *	2007-02-14	2010-04-08	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en)	2007-02-16	2008-08-21	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
CN104127878A (zh) *	2007-03-14	2014-11-05	恩多塞特公司	结合配体连接的微管溶素递药缀合物
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
CA2690943A1 (en)	2007-06-25	2008-12-31	Endocyte, Inc.	Conjugates containing hydrophilic spacer linkers
EP2209374B1 (en) *	2007-10-25	2014-12-03	Endocyte, Inc.	Tubulysins and processes for preparing
WO2011027786A1 (ja) *	2009-09-07	2011-03-10	ニプロパッチ株式会社	経皮吸収型製剤
US10080805B2 (en)	2012-02-24	2018-09-25	Purdue Research Foundation	Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
EA201590622A1 (ru)	2012-10-16	2015-10-30	Эндосайт, Инк.	Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 BG BG056469A patent/BG33296A3/bg unknown
- 1979-04-20 BG BG056470A patent/BG33297A3/bg unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 BG BG043323A patent/BG33294A3/bg unknown
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
JPS6245873B2 (bg)	1987-09-29
ES479753A1 (es)	1980-08-16
DK147484B (da)	1984-08-27
PL119416B1 (en)	1981-12-31
FR2423495B1 (bg)	1983-02-11
BG33294A3 (bg)	1983-01-14
DD143075A5 (de)	1980-07-30
CS218584B2 (en)	1983-02-25
AU4609779A (en)	1979-10-25
ES479754A1 (es)	1980-08-16
CS218585B2 (en)	1983-02-25
DK147484C (da)	1985-03-25
YU93179A (en)	1983-01-21
EP0005051A1 (en)	1979-10-31
RO80084A (ro)	1983-02-01
LU81166A1 (fr)	1979-09-07
IL57168A0 (en)	1979-07-25
CS218583B2 (en)	1983-02-25
IE790795L (en)	1979-10-20
AR228940A1 (es)	1983-05-13
US4166810A (en)	1979-09-04
GB2019396A (en)	1979-10-31
AT369010B (de)	1982-11-25
RO81114B (ro)	1983-01-30
DE2964130D1 (en)	1983-01-05
FR2423495A1 (fr)	1979-11-16
EP0005051B1 (en)	1982-12-01
HU181431B (en)	1983-07-28
ZA791856B (en)	1980-11-26
DK160679A (da)	1979-10-21
PT69496A (en)	1979-05-01
RO80084B (ro)	1983-01-30
AU527109B2 (en)	1983-02-17
GR69987B (bg)	1982-07-22
PH14163A (en)	1981-03-19
SU1225490A3 (ru)	1986-04-15
CH643269A5 (fr)	1984-05-30
RO81037A (ro)	1983-02-01
IL57168A (en)	1983-10-31
SU1061698A3 (ru)	1983-12-15
RO81114A (ro)	1983-02-01
JPS54141798A (en)	1979-11-05
EG14867A (en)	1986-09-30
CA1097629A (en)	1981-03-17
PL215911A1 (bg)	1980-03-24
GB2019396B (en)	1982-09-15
NZ190213A (en)	1982-12-21
ATA291279A (de)	1982-04-15
FI791286A (fi)	1979-10-21
RO81037B (ro)	1983-01-30
IE48213B1 (en)	1984-10-31
BG33297A3 (bg)	1983-01-14
BG33296A3 (bg)	1983-01-14
PL125470B1 (en)	1983-05-31
SU893135A3 (ru)	1981-12-23

Publication	Publication Date	Title
LU81166A1 (fr)	1979-09-07	Derives anti-tumoraux de carboxyhydrazide en c-3 de la 4-desacetyl vincaleucoblastine
LU80925A1 (fr)	1979-06-18	Derives de dehydrocyclicimino-acides
BE867269A (fr)	1978-11-20	Derives de thiopropanoylamino-acides
ES494635A0 (es)	1981-08-16	Procedimiento de preparacion de derivados de tiadiazol
FR2510108B1 (fr)	1986-02-14	Derives de pyridine
MC1252A1 (fr)	1980-01-14	Derives de piperazine
BE863314A (fr)	1978-07-25	Derives enti-paludeens de la pyrimidine
DE2964681D1 (de)	1983-03-17	4-amino-3-sulfonamido pyridine derivatives
FI790281A (fi)	1979-08-01	Prostaglandin-derivat
FR2301253A1 (fr)	1976-09-17	Derives de la
MC1338A1 (fr)	1981-04-21	Derives de sucres
PL204616A1 (pl)	1979-04-23	Sposob wytwarzania pochodnych 1-oksadetiacefamowych
MC1258A1 (fr)	1980-01-14	Derives pyrrolidiniques
BE853578A (fr)	1977-10-14	Derives de thiouree
MC1422A1 (fr)	1982-10-18	Derives acyles
BE877694A (fr)	1979-11-05	Derives de 1-phenyl-1-propanol.
BE859567A (fr)	1978-04-11	Derives piperidylideniques de benzo-xanthenes
DK152979A (da)	1979-10-13	Pyridinderivater
BE874488A (fr)	1979-08-27	Derives benzylideniques
MC1275A1 (fr)	1980-05-23	Derives de carbazole
MC1347A1 (fr)	1981-06-22	Derives de pyridazopyridazine
BE875592A (fr)	1979-10-15	Derives de pyrrolidinecarboxaldehyde et de piperidinecarboxaldehyde et leur preparation
BE866933A (fr)	1978-11-10	Nouveaux derives de fortmicine
MC1195A1 (fr)	1979-02-23	Derives acyles
DK320479A (da)	1980-02-01	Pyridoxinderivater