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BE862107A - Nouveaux derives de 1,4-dihydropyridine substitues en position 2, leur procede de preparation et medicament les contenant - Google Patents

Nouveaux derives de 1,4-dihydropyridine substitues en position 2, leur procede de preparation et medicament les contenant

Info

Publication number
BE862107A
BE862107A BE183669A BE183669A BE862107A BE 862107 A BE862107 A BE 862107A BE 183669 A BE183669 A BE 183669A BE 183669 A BE183669 A BE 183669A BE 862107 A BE862107 A BE 862107A
Authority
BE
Belgium
Prior art keywords
preparation process
product containing
medicinal product
new derivatives
dihydropyridine
Prior art date
Application number
BE183669A
Other languages
English (en)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BE862107A publication Critical patent/BE862107A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE183669A 1976-12-22 1977-12-21 Nouveaux derives de 1,4-dihydropyridine substitues en position 2, leur procede de preparation et medicament les contenant BE862107A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762658183 DE2658183A1 (de) 1976-12-22 1976-12-22 In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
BE862107A true BE862107A (fr) 1978-06-21

Family

ID=5996272

Family Applications (1)

Application Number Title Priority Date Filing Date
BE183669A BE862107A (fr) 1976-12-22 1977-12-21 Nouveaux derives de 1,4-dihydropyridine substitues en position 2, leur procede de preparation et medicament les contenant

Country Status (16)

Country Link
US (1) US4188395A (fr)
JP (1) JPS5379873A (fr)
AT (1) AT361477B (fr)
AU (1) AU516921B2 (fr)
BE (1) BE862107A (fr)
CA (1) CA1105934A (fr)
CH (1) CH635323A5 (fr)
DE (1) DE2658183A1 (fr)
DK (1) DK571677A (fr)
ES (1) ES465290A1 (fr)
FI (1) FI773867A (fr)
FR (1) FR2378763A1 (fr)
GB (1) GB1560280A (fr)
IL (1) IL53639A (fr)
NL (1) NL7714074A (fr)
SE (1) SE7714607L (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302460A (en) 1979-03-27 1981-11-24 The Boots Company Limited 4-Quinolinones having antihypertensive activity
US4430333A (en) 1981-03-14 1984-02-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
CA1117117A (fr) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. Derives de la 2-methyl-dihydropyridine, methodes de preparation, et composition pharmaceutique de ces derives
YU42386B (en) * 1981-03-13 1988-08-31 Krka Process for preparing 1,4-dihydro-pyridine derivatives
JPS57175166A (en) 1981-04-23 1982-10-28 Banyu Pharmaceut Co Ltd Carbamoyloxyalkyl-1,4-dihydropyridine derivative and its preparation
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
EP0100189B1 (fr) * 1982-07-22 1986-05-28 Pfizer Limited Agents anti-ischémiques et antihypertensifs dihydropyridines
HU192166B (en) * 1982-08-06 1987-05-28 Banyu Pharma Co Ltd Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives
EP0107293A3 (fr) * 1982-09-04 1984-06-06 Pfizer Limited Dihydropyridines
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
PL140573B1 (en) * 1982-12-21 1987-05-30 Pfizer Method of obtaining new dihydropyridine derivatives
US4515799A (en) * 1983-02-02 1985-05-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
FI852359L (fi) * 1984-06-27 1985-12-28 Hoffmann La Roche Dihydropyridinderivat.
GB8421039D0 (en) * 1984-08-17 1984-09-19 Wyeth John & Brother Ltd Heterocyclic compounds
GR851819B (fr) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
US4833150A (en) * 1985-03-14 1989-05-23 Nelson Research & Development Co. 1,4-dihydropyridines
FI862343A (fi) * 1985-06-17 1986-12-18 Warner Lambert Co Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar.
IT1215299B (it) * 1985-08-06 1990-01-31 Boehringer Biochemia Srl Diidropiridine 2-tiosostituite, metodo per la loro preparazione e composizione farmaceutiche che le contengono.
IT1215298B (it) * 1985-08-06 1990-01-31 Boehringer Biochemia Srl 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione.
KR930011486B1 (ko) * 1985-08-06 1993-12-08 베링거 만하임 이탈리아 에스.피.에이. 제약상 유효한 2-티오메틸-치환-1,4-디히드로피리딘
GB8526411D0 (en) * 1985-10-25 1985-11-27 Pfizer Ltd Dihydropyridines
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB8531625D0 (en) * 1985-12-23 1986-02-05 Shell Int Research Complex-forming polymers
US4849436A (en) * 1986-03-11 1989-07-18 Nelson Research & Development Co. 1,4-dihydropyridines
IT1197012B (it) * 1986-07-29 1988-11-25 Boehringer Biochemia Srl 2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono
US4983740A (en) * 1986-08-04 1991-01-08 Adir Et Compagnie Process for 1,4-dihydropyridine compounds
FR2602231B1 (fr) * 1986-08-04 1988-10-28 Adir Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
MX9701245A (es) * 1996-02-19 1998-04-30 Pfizer Compuestos de 1,4 dihidropiridina.
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
US3883543A (en) * 1969-05-10 1975-05-13 Bayer Ag N-alkyl-1,4-dihydropyridines
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3974278A (en) * 1973-07-12 1976-08-10 Bayer Aktiengesellschaft 1,4-Dihydropyridine esters
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302460A (en) 1979-03-27 1981-11-24 The Boots Company Limited 4-Quinolinones having antihypertensive activity
US4430333A (en) 1981-03-14 1984-02-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents

Also Published As

Publication number Publication date
US4188395A (en) 1980-02-12
NL7714074A (nl) 1978-06-26
FR2378763A1 (fr) 1978-08-25
GB1560280A (en) 1980-02-06
SE7714607L (sv) 1978-06-23
ATA912977A (de) 1980-08-15
ES465290A1 (es) 1978-09-16
IL53639A (en) 1981-11-30
AU3170877A (en) 1979-06-28
FR2378763B1 (fr) 1980-09-19
AU516921B2 (en) 1981-07-02
FI773867A (fi) 1978-06-23
CA1105934A (fr) 1981-07-28
AT361477B (de) 1981-03-10
JPS6131100B2 (fr) 1986-07-17
CH635323A5 (de) 1983-03-31
DE2658183A1 (de) 1978-07-06
JPS5379873A (en) 1978-07-14
DK571677A (da) 1978-06-23
IL53639A0 (en) 1978-03-10

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