BE487301A - - Google Patents

Info

Publication number: BE487301A
Authority: BE; Belgium
Prior art keywords: aureomycin; fermentation; desc; page number; clms page
Prior art date: 1948-02-11

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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1948-02-11

Family has litigation

Publication of BE487301A publication Critical patent/BE487301A/fr

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34831437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE487301(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1948-02-11 Priority claimed from US7592A external-priority patent/US2482055A/en

1948-11-30 Priority claimed from US62765A external-priority patent/US2586766A/en

1958-11-21 Priority claimed from FR779703A external-priority patent/FR74539E/fr

Links

CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 95
CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 90
CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 89
229960004475 chlortetracycline Drugs 0.000 claims description 89
235000019365 chlortetracycline Nutrition 0.000 claims description 89
238000000855 fermentation Methods 0.000 claims description 62
230000004151 fermentation Effects 0.000 claims description 62
239000000126 substance Substances 0.000 claims description 52
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 48
239000002253 acid Substances 0.000 claims description 44
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 41
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 40
150000003839 salts Chemical class 0.000 claims description 40
239000002904 solvent Substances 0.000 claims description 40
238000000034 method Methods 0.000 claims description 39
239000007787 solid Substances 0.000 claims description 34
238000010521 absorption reaction Methods 0.000 claims description 29
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 22
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 18
229930006000 Sucrose Natural products 0.000 claims description 18
239000000706 filtrate Substances 0.000 claims description 18
239000005720 sucrose Substances 0.000 claims description 18
238000000605 extraction Methods 0.000 claims description 17
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
239000002245 particle Substances 0.000 claims description 16
230000003115 biocidal effect Effects 0.000 claims description 15
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235000015097 nutrients Nutrition 0.000 claims description 13
DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims description 12
229910052799 carbon Inorganic materials 0.000 claims description 12
150000001768 cations Chemical class 0.000 claims description 12
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 11
150000007513 acids Chemical class 0.000 claims description 11
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239000011575 calcium Substances 0.000 claims description 11
229910000019 calcium carbonate Inorganic materials 0.000 claims description 11
238000004519 manufacturing process Methods 0.000 claims description 11
CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 11
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 10
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 10
229910052791 calcium Inorganic materials 0.000 claims description 10
150000001720 carbohydrates Chemical class 0.000 claims description 10
235000005822 corn Nutrition 0.000 claims description 10
238000002803 maceration Methods 0.000 claims description 10
229910052749 magnesium Inorganic materials 0.000 claims description 10
239000011777 magnesium Substances 0.000 claims description 10
229910052712 strontium Inorganic materials 0.000 claims description 10
239000003513 alkali Substances 0.000 claims description 9
239000007788 liquid Substances 0.000 claims description 9
229910052757 nitrogen Inorganic materials 0.000 claims description 9
230000008569 process Effects 0.000 claims description 9
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 8
229910052921 ammonium sulfate Inorganic materials 0.000 claims description 8
235000011130 ammonium sulphate Nutrition 0.000 claims description 8
241000186984 Kitasatospora aureofaciens Species 0.000 claims description 7
239000007864 aqueous solution Substances 0.000 claims description 7
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 6
239000013078 crystal Substances 0.000 claims description 6
238000001914 filtration Methods 0.000 claims description 6
229910052739 hydrogen Inorganic materials 0.000 claims description 6
239000003960 organic solvent Substances 0.000 claims description 6
238000001228 spectrum Methods 0.000 claims description 6
229910052500 inorganic mineral Inorganic materials 0.000 claims description 5
239000011707 mineral Substances 0.000 claims description 5
239000003242 anti bacterial agent Substances 0.000 claims description 4
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims description 4
239000004137 magnesium phosphate Substances 0.000 claims description 4
229960002261 magnesium phosphate Drugs 0.000 claims description 4
229910000157 magnesium phosphate Inorganic materials 0.000 claims description 4
235000010994 magnesium phosphates Nutrition 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 4
238000001179 sorption measurement Methods 0.000 claims description 4
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
238000010564 aerobic fermentation Methods 0.000 claims description 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
239000000460 chlorine Substances 0.000 claims description 3
229910052801 chlorine Inorganic materials 0.000 claims description 3
239000001257 hydrogen Substances 0.000 claims description 3
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 3
239000001301 oxygen Substances 0.000 claims description 3
229910052760 oxygen Inorganic materials 0.000 claims description 3
230000020477 pH reduction Effects 0.000 claims description 3
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 3
239000001166 ammonium sulphate Substances 0.000 claims description 2
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238000000354 decomposition reaction Methods 0.000 claims description 2
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150000007530 organic bases Chemical class 0.000 claims 2
235000001674 Agaricus brunnescens Nutrition 0.000 claims 1
JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 1
229910001422 barium ion Inorganic materials 0.000 claims 1
238000010828 elution Methods 0.000 claims 1
229910001425 magnesium ion Inorganic materials 0.000 claims 1
230000001376 precipitating effect Effects 0.000 claims 1
230000003381 solubilizing effect Effects 0.000 claims 1
229910001427 strontium ion Inorganic materials 0.000 claims 1
239000002609 medium Substances 0.000 description 50
239000000047 product Substances 0.000 description 26
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
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235000010419 agar Nutrition 0.000 description 17
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 16
235000019441 ethanol Nutrition 0.000 description 16
238000000746 purification Methods 0.000 description 15
239000008272 agar Substances 0.000 description 14
239000000284 extract Substances 0.000 description 14
239000012071 phase Substances 0.000 description 14
239000002244 precipitate Substances 0.000 description 13
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 12
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
239000000463 material Substances 0.000 description 12
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FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
-1 tyrocidin Chemical compound 0.000 description 10
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
235000014633 carbohydrates Nutrition 0.000 description 9
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239000012535 impurity Substances 0.000 description 9
241000894007 species Species 0.000 description 9
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 8
238000004458 analytical method Methods 0.000 description 8
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 8
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QYAPHLRPFNSDNH-MRFRVZCGSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride Chemical compound Cl.C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O QYAPHLRPFNSDNH-MRFRVZCGSA-N 0.000 description 6
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AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 6
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OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 5
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 5
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GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 5
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239000005018 casein Substances 0.000 description 4
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
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QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
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XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 2
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WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
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TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
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239000010452 phosphate Substances 0.000 description 1
239000002574 poison Substances 0.000 description 1
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BYTCDABWEGFPLT-UHFFFAOYSA-L potassium;sodium;dihydroxide Chemical compound [OH-].[OH-].[Na+].[K+] BYTCDABWEGFPLT-UHFFFAOYSA-L 0.000 description 1
239000002243 precursor Substances 0.000 description 1
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OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
229940007042 proteus vulgaris Drugs 0.000 description 1
239000002994 raw material Substances 0.000 description 1
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150000003388 sodium compounds Chemical class 0.000 description 1
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239000004455 soybean meal Substances 0.000 description 1
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229960005322 streptomycin Drugs 0.000 description 1
NRAUADCLPJTGSF-VLSXYIQESA-N streptothricin F Chemical compound NCCC[C@H](N)CC(=O)N[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)O[C@H]1\N=C/1N[C@H](C(=O)NC[C@H]2O)[C@@H]2N\1 NRAUADCLPJTGSF-VLSXYIQESA-N 0.000 description 1
229910000018 strontium carbonate Inorganic materials 0.000 description 1
159000000008 strontium salts Chemical class 0.000 description 1
238000000859 sublimation Methods 0.000 description 1
230000008022 sublimation Effects 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
108010082567 subtilin Proteins 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
BZWKPZBXAMTXNQ-UHFFFAOYSA-N sulfurocyanidic acid Chemical class OS(=O)(=O)C#N BZWKPZBXAMTXNQ-UHFFFAOYSA-N 0.000 description 1
235000020275 sunflower milk Nutrition 0.000 description 1
FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 1
206010061393 typhus Diseases 0.000 description 1
238000005292 vacuum distillation Methods 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
238000012795 verification Methods 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/889—Streptomyces aureofaciens

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BE487301D 1948-02-11 BE487301A (es)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US7592A US2482055A (en)	1948-02-11	1948-02-11	Aureomycin and preparation of same
US1080407XA	1948-11-30	1948-11-30
US62765A US2586766A (en)	1948-02-11	1948-11-30	Purifying aureomycin by chromatographic adsorption
US65512A US2609329A (en)	1948-02-11	1948-12-15	Process for producing aureomycin
FR779703A FR74539E (fr)	1948-02-11	1958-11-21	Perfectionnements à la préparation de substances antibiotiques

Publications (1)

Publication Number	Publication Date
BE487301A true BE487301A (es)

Family

ID=34831437

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE487301D BE487301A (es)	1948-02-11

Country Status (2)

Country	Link
US (1)	US2609329A (es)
BE (1)	BE487301A (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2709672A (en) *	1952-04-04	1955-05-31	American Cyanamid Co	Production of chlortetracycline
US2763681A (en) *	1953-06-25	1956-09-18	American Cyanamid Co	Chlortetracycline, purification and alkaline earth salts
US2904473A (en) *	1953-08-12	1959-09-15	American Cyanamid Co	Selection of corn steep liquor by measurement of oxidation-reduction potential
US2793165A (en) *	1953-09-23	1957-05-21	American Cyanamid Co	Employment of peroxide formation inhibitor in nutrient media containing triglyceride oil
US2866738A (en) *	1955-01-12	1958-12-30	American Cyanamid Co	Deionized corn steep liquor in production of tetracycline
US2734018A (en) *	1953-09-28	1956-02-07		Ircso
US2699054A (en) *	1953-10-09	1955-01-11	Lloyd H Conover	Tetracycline
NL103776C (es) *	1953-12-04
US2712517A (en) *	1954-03-03	1955-07-05	Bristol Lab Inc	Production of tetracycline and substituted tetracyclines
US2847471A (en) *	1955-03-04	1958-08-12	Olin Mathieson	Method for purifying tetracycline
US2782975A (en) *	1955-04-20	1957-02-26	American Cyanamid Co	Sprayable amorphous antibiotic composition, pressurized container with same, and method of preparing
US3105016A (en) *	1956-04-25	1963-09-24	American Cyanamid Co	Process of producing bromo-tetracycline
CH365484A (fr) *	1956-05-28	1962-11-15	American Cyanamid Co	Procédé de préparation d'une substance antibiotique
US2871167A (en) *	1956-12-12	1959-01-27	American Cyanamid Co	Chlortetracycline fermentation
US2970947A (en) *	1958-06-20	1961-02-07	American Cyanamid Co	Process of producing an antibiotic of the tetracycline series
US2886595A (en) *	1958-09-30	1959-05-12	Bristol Lab Inc	Tetracycline recovery
US3050446A (en) *	1960-07-28	1962-08-21	American Cyanamid Co	Fermentation of chlortetracycline and demethylchlorotetracycline
US4402986A (en) *	1981-07-23	1983-09-06	Stauffer Chemical Company	Bulk starter media

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1849053A (en) *	1927-11-26	1932-03-15	Pfizer Charles & Co	Production of gluconic acid
US2448790A (en) *	1943-05-15	1948-09-07	Merck & Co Inc	Process for the production of penicillin
US2422230A (en) *	1943-09-11	1947-06-17	Merck & Co Inc	Production of streptothricin
US2424832A (en) *	1944-01-21	1947-07-29	Squibb & Sons Inc	Process for producing penicillin
NL68936C (es) *	1946-01-11
US2504067A (en) *	1946-02-18	1950-04-11	Upjohn Co	Process for production of streptomycin using fermentation solubles
US2482055A (en) *	1948-02-11	1949-09-13	American Cyanamid Co	Aureomycin and preparation of same

0
- BE BE487301D patent/BE487301A/fr unknown
1948
- 1948-12-15 US US65512A patent/US2609329A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US2609329A (en)	1952-09-02

Publication	Publication Date	Title
CH293562A (fr)	1953-09-30	Procédé de préparation d'une substance antibiotique.
BE487301A (es)
CH304875A (fr)	1955-01-31	Procédé de préparation d'une nouvelle substance antibiotique.
BE530983A (es)
DE2517316A1 (de)	1975-10-23	Clavulansaeure, deren salze und ester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR1465395A (fr)	1967-01-13	Composé nouveau, la décoyinine et son procédé de fabrication
CH298331A (fr)	1954-04-30	Procédé de préparation d'un nouvel antibiotique.
BE572450A (es)
US3718742A (en)	1973-02-27	Antibiotics yl 704 and preparation thereof
EP0023178A1 (fr)	1981-01-28	Procédé de préparation de solutions concentrées d'amygdaline sous sa forme naturelle
CH280317A (fr)	1952-01-15	Procédé de préparation d'un nouvel antibiotique.
BE558382A (es)
BE641209A (es)
BE538487A (es)
BE530635A (es)
BE517461A (es)
BE544035A (es)
BE493857A (es)
CH650785A5 (fr)	1985-08-15	Substance antibiotique et procede pour sa production.
CH318710A (fr)	1957-01-15	Procédé de préparation d'un nouvel antibiotique
BE522647A (es)
BE548510A (es)
CH314485A (fr)	1956-06-15	Procédé de préparation d'un nouvel antibiotique
BE553388A (es)
BE600096A (es)