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AU9336098A - The use of steroid saponin compounds to prevent senility, and novel steroid saponin compounds - Google Patents

The use of steroid saponin compounds to prevent senility, and novel steroid saponin compounds

Info

Publication number
AU9336098A
AU9336098A AU93360/98A AU9336098A AU9336098A AU 9336098 A AU9336098 A AU 9336098A AU 93360/98 A AU93360/98 A AU 93360/98A AU 9336098 A AU9336098 A AU 9336098A AU 9336098 A AU9336098 A AU 9336098A
Authority
AU
Australia
Prior art keywords
steroid saponin
saponin compounds
novel
compounds
senility
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU93360/98A
Other languages
English (en)
Inventor
Junxing Dong
Beiping Ma
Bingji Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Radiation Medicine of CAMMS
Original Assignee
Institute of Radiation Medicine of CAMMS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Radiation Medicine of CAMMS filed Critical Institute of Radiation Medicine of CAMMS
Publication of AU9336098A publication Critical patent/AU9336098A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU93360/98A 1997-09-26 1998-09-28 The use of steroid saponin compounds to prevent senility, and novel steroid saponin compounds Abandoned AU9336098A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN97119680A CN1131237C (zh) 1997-09-26 1997-09-26 甾体皂甙防治老年性痴呆的用途及新的甾体皂甙
CN97119680 1997-09-26
PCT/CN1998/000204 WO1999016786A1 (fr) 1997-09-26 1998-09-28 Utilisation de composes de saponine et de steroides pour prevenir la senilite et nouveaux composes de saponine steroide

Publications (1)

Publication Number Publication Date
AU9336098A true AU9336098A (en) 1999-04-23

Family

ID=5175496

Family Applications (1)

Application Number Title Priority Date Filing Date
AU93360/98A Abandoned AU9336098A (en) 1997-09-26 1998-09-28 The use of steroid saponin compounds to prevent senility, and novel steroid saponin compounds

Country Status (9)

Country Link
US (1) US6593301B1 (zh)
EP (1) EP1024146B1 (zh)
JP (1) JP4338306B2 (zh)
KR (1) KR100354826B1 (zh)
CN (1) CN1131237C (zh)
AU (1) AU9336098A (zh)
CA (1) CA2304770C (zh)
DE (1) DE69841421D1 (zh)
WO (1) WO1999016786A1 (zh)

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GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
DE69929177T2 (de) * 1998-03-26 2006-08-24 Phytopharm Plc, Godmanchester Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit
GB9905275D0 (en) 1999-03-08 1999-04-28 Phytopharm Ltd Treatment of conditions associated with membrane-bound receptors and their function
US20030118673A1 (en) * 1998-03-26 2003-06-26 Zongqin Xia Smilagenin and anzurogenin-D for the treatment of alzheimer's disease
GB2347676A (en) 1999-03-08 2000-09-13 Phytopharm Plc Screening method
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
CN1422861A (zh) * 2001-12-03 2003-06-11 张晓� 皂甙化合物的用途
WO2003077869A2 (en) * 2002-03-15 2003-09-25 Samaritan Pharmaceuticals, Inc Neuroprotective spirostenol pharmaceutical compositions
US20050130948A1 (en) * 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives
KR101130212B1 (ko) * 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법
BR0308788A (pt) * 2002-03-27 2005-01-11 Phytopharm Plc Processos terapêuticos e usos de sapogeninas e seus derivados
NZ547897A (en) * 2002-03-27 2008-02-29 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
ES2323363T3 (es) * 2002-03-27 2009-07-14 Phytopharm Plc Usos terapeuticos de sapogeninas.
US20060009433A1 (en) * 2003-03-14 2006-01-12 Zhi-Xing Yao Neuroprotective spirostenol pharmaceutical compositions
GB0513881D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
US20080182801A1 (en) * 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
CN1692914B (zh) * 2004-04-29 2010-05-26 中国人民解放军军事医学科学院放射医学研究所 知母皂苷bⅱ在制备用于防治脑卒中药物或产品中的用途
CN100427500C (zh) * 2004-04-29 2008-10-22 中国人民解放军军事医学科学院放射医学研究所 知母皂苷bⅱ的制备方法
CN1315866C (zh) * 2004-05-09 2007-05-16 上海正祥天然药物科技有限公司 天冬总甾体皂苷提取物及其制备方法与应用
CN1732955B (zh) * 2004-08-03 2011-02-09 山东绿叶制药有限公司 以知母总皂苷元为活性成分的药物组合物及其制备方法和用途
CN1754541A (zh) * 2004-09-30 2006-04-05 成都地奥制药集团有限公司 甾体皂苷药物组合物及其制备方法和用途
AU2005295617A1 (en) * 2004-10-14 2006-04-27 Georgetown University Neuroprotective spirostenol pharmaceutical compositions
CN103122019A (zh) * 2005-05-17 2013-05-29 萨托里医药公司 用于治疗神经变性障碍的化合物
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513888D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
HUE035328T2 (en) * 2005-10-28 2018-05-02 Univ Industry Cooperation Group Kyung Hee Univ Extract from Dioscoreaceae Family Plants and Composition Containing it for Prevention or Treatment of Peripheral Neuropathy
JP2011518846A (ja) * 2008-04-30 2011-06-30 インスティテュート オブ ラジエーション メディシン，アカデミー オブ ミリタリー メディカル サイエンシズ，ピーエルエー チモサポニンｂｉｉの合成
US20120034193A1 (en) 2009-01-24 2012-02-09 Daryl Rees Treatment of neurotrophic factor mediated disorders
CN102311481B (zh) * 2010-07-01 2012-12-05 中国科学院上海药物研究所 毛红椿酸甲酯及其制备方法和用途
WO2012010896A1 (en) 2010-07-20 2012-01-26 Phytopharm Plc Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
KR101341693B1 (ko) * 2011-03-16 2013-12-16 동아에스티 주식회사 생약추출물을 함유하는 퇴행성 신경질환의 치료 및 예방을 위한 조성물
US11319338B2 (en) 2012-04-03 2022-05-03 Goldporp Pharma Limited Timosaponin compounds
KR101777920B1 (ko) * 2015-07-27 2017-09-14 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물
CN105153266B (zh) * 2015-07-30 2017-03-22 中国人民解放军第四军医大学 一种甾体皂苷类化合物及其在制备抗肿瘤药物中的应用
MX2018004489A (es) * 2015-10-16 2019-01-21 Inst Tecnologico Estudios Superiores Monterrey Extracto de agavaceae que comprende saponinas esteroidales y su uso para tratar y/o prevenir patologías relacionadas con desórdenes metabólicos.
CN105440098B (zh) * 2015-12-31 2017-04-19 南京中医药大学 一种制备知母皂苷n的方法
CN107488204A (zh) * 2017-08-17 2017-12-19 烟台大学 达玛烷型人参皂苷（元）及其ocotillol型衍生物的抗炎用途
CN114642677A (zh) * 2020-12-21 2022-06-21 上海凯屹医药科技有限公司 一种稳定的含有苦丁皂苷类化合物的液体药物组合物

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IT1144136B (it) * 1980-03-05 1986-10-29 Zenyaku Kogyo Kk Glucosidi di condurango agenti antitumorali che li comprendono e procedimento per la loro preparazione
JP2631686B2 (ja) * 1988-03-01 1997-07-16 湧永製薬株式会社 新規ステロイドサポニンおよびその製造法ならびにこれらの誘導体の新規用途
JPH02243631A (ja) * 1989-03-15 1990-09-27 Wakunaga Pharmaceut Co Ltd 抗発癌プロモーター
JPH0454194A (ja) * 1990-06-19 1992-02-21 Wakunaga Pharmaceut Co Ltd 新規ステロイド配糖体およびこの製造法ならびにこれを有効成分とする血糖降下剤
CN1088748A (zh) * 1993-01-01 1994-07-06 赵广才 荞麦保健食品
DE4303214A1 (de) * 1993-02-04 1994-08-11 Wolfgang Marks Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone
US5502038A (en) * 1993-06-21 1996-03-26 Medical Research Foundation Of Oregon Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption
CN1102186A (zh) * 1993-10-29 1995-05-03 沈阳医学院 中药薤白新成分的鉴定及用途
JPH07267864A (ja) * 1994-03-28 1995-10-17 Tsumura & Co 体温降下剤
JPH0859476A (ja) * 1994-08-22 1996-03-05 Shiratori Seiyaku Kk 肝炎治療剤
CN1138984A (zh) * 1995-06-26 1997-01-01 军事医学科学院放射医学研究所 新型甙类抗血栓药物
KR0169536B1 (ko) * 1996-02-27 1999-01-15 손경식 신규한 인삼 사포닌, 그의 제조방법 및 이를 유효성분으로 하는 항종양제

Also Published As

Publication number Publication date
KR100354826B1 (ko) 2002-10-05
EP1024146A1 (en) 2000-08-02
EP1024146B1 (en) 2009-12-30
CN1131237C (zh) 2003-12-17
JP4338306B2 (ja) 2009-10-07
JP2001518477A (ja) 2001-10-16
CA2304770A1 (en) 1999-04-08
DE69841421D1 (de) 2010-02-11
WO1999016786A1 (fr) 1999-04-08
CA2304770C (en) 2009-01-20
US6593301B1 (en) 2003-07-15
EP1024146A4 (en) 2006-02-08
CN1212966A (zh) 1999-04-07
KR20010030746A (ko) 2001-04-16

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase