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AU8973498A - Triiodine aromates containing perfluoroalkyl groups, method for the production and use thereof as contrast agents - Google Patents

Triiodine aromates containing perfluoroalkyl groups, method for the production and use thereof as contrast agents

Info

Publication number
AU8973498A
AU8973498A AU89734/98A AU8973498A AU8973498A AU 8973498 A AU8973498 A AU 8973498A AU 89734/98 A AU89734/98 A AU 89734/98A AU 8973498 A AU8973498 A AU 8973498A AU 8973498 A AU8973498 A AU 8973498A
Authority
AU
Australia
Prior art keywords
triiodine
aromates
production
contrast agents
perfluoroalkyl groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU89734/98A
Inventor
Michael Bauer
Thomas Frenzel
Werner Krause
Ulrich Niedballa
Johannes Dr. Platzek
Wolfgang Schlecker
Hanns-Joachim Weinmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU8973498A publication Critical patent/AU8973498A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU89734/98A 1997-07-11 1998-07-08 Triiodine aromates containing perfluoroalkyl groups, method for the production and use thereof as contrast agents Abandoned AU8973498A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19731300 1997-07-11
DE1997131300 DE19731300C1 (en) 1997-07-11 1997-07-11 Triiodoaromatics containing perfluoroalkyl groups, process for their preparation and their use as contrast agents
PCT/EP1998/004169 WO1999002193A2 (en) 1997-07-11 1998-07-08 Triiodine aromates containing perfluoroalkyl groups, method for the production and use thereof as contrast agents

Publications (1)

Publication Number Publication Date
AU8973498A true AU8973498A (en) 1999-02-08

Family

ID=7836420

Family Applications (1)

Application Number Title Priority Date Filing Date
AU89734/98A Abandoned AU8973498A (en) 1997-07-11 1998-07-08 Triiodine aromates containing perfluoroalkyl groups, method for the production and use thereof as contrast agents

Country Status (3)

Country Link
AU (1) AU8973498A (en)
DE (1) DE19731300C1 (en)
WO (1) WO1999002193A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19731591C2 (en) * 1997-07-17 1999-09-16 Schering Ag Pharmaceutical compositions containing triiodoaromatics containing perfluoroalkyl groups and their use in tumor therapy and interventional radiology
JP2003505519A (en) 1999-07-29 2003-02-12 エピックス メディカル， インコーポレイテッド Targeting multimeric imaging agents through multidentate binding
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
MXPA04001049A (en) 2001-08-03 2004-05-20 Glaxo Group Ltd Surfactant compounds and uses thereof.
DE10209018C1 (en) * 2002-02-28 2003-11-20 Schering Ag Perfluoroalkyl group-containing micelle-forming triiodine aromatics, processes for their production and their use as contrast media and diagnostic media containing them
CN113816868B (en) * 2021-09-28 2023-07-21 浙江海洲制药有限公司 Synthesis method of iohexol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55100312A (en) * 1979-01-25 1980-07-31 Toshiro Wada Contrast medium for blood vessel
US5250283A (en) * 1990-03-28 1993-10-05 Molecular Biosystems, Inc. Organic contrast agent analog and method of making same
FR2700696B1 (en) * 1993-01-28 1995-04-07 Atta Dispersions, emulsions, microemulsions, gels and compositions for biomedical use comprising an iodinated fluorinated organic compound, usable in particular as a contrast agent.
US5316755A (en) * 1993-02-02 1994-05-31 Sterling Winthrop Inc. Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract
US5326553A (en) * 1993-02-02 1994-07-05 Sterling Winthrop Inc. Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract
US5344638A (en) * 1993-03-11 1994-09-06 Sterling Winthrop Inc. Compositions of iodobenzoic acid derivatives for visualization of the gastrointestinal tract
US5401493A (en) * 1993-03-26 1995-03-28 Molecular Biosystems, Inc. Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same
US5318769A (en) * 1993-03-31 1994-06-07 Sterling Winthrop Inc. Compositions of iodophenyl esters for X-ray visualization of the gastrointestinal tract
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents

Also Published As

Publication number Publication date
DE19731300C1 (en) 1999-01-21
WO1999002193A2 (en) 1999-01-21
WO1999002193A3 (en) 1999-05-14

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase