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AU8798691A - New erythromycin derivatives, their preparation process, the new intermediates obtained and their use as medicaments - Google Patents

New erythromycin derivatives, their preparation process, the new intermediates obtained and their use as medicaments

Info

Publication number
AU8798691A
AU8798691A AU87986/91A AU8798691A AU8798691A AU 8798691 A AU8798691 A AU 8798691A AU 87986/91 A AU87986/91 A AU 87986/91A AU 8798691 A AU8798691 A AU 8798691A AU 8798691 A AU8798691 A AU 8798691A
Authority
AU
Australia
Prior art keywords
new
medicaments
image
preparation process
forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU87986/91A
Other versions
AU640290B2 (en
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Claude Fromentin
Odile Le Martret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9014499A external-priority patent/FR2669337B1/en
Priority claimed from FR9106333A external-priority patent/FR2677025B1/en
Priority claimed from FR9110728A external-priority patent/FR2680790B1/en
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of AU8798691A publication Critical patent/AU8798691A/en
Application granted granted Critical
Publication of AU640290B2 publication Critical patent/AU640290B2/en
Assigned to HOECHST MARION ROUSSEL reassignment HOECHST MARION ROUSSEL Alteration of Name(s) in Register under S187 Assignors: ROUSSEL-UCLAF
Assigned to AVENTIS PHARMA S.A. reassignment AVENTIS PHARMA S.A. Alteration of Name(s) in Register under S187 Assignors: HOECHST MARION ROUSSEL
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to the compounds (I): <IMAGE> in which, - either X and X' form C=O or C=NOR with R=H, heterocycle, alkyl, alkenyl, alkynyl, optionally substituted, or X represents a radical <IMAGE> R<a>, Rb representing H or hydrocarbon radical or forming a heterocycle with N or a 9-N, 11-O ring with A and X' = H, - Y and Y' have the same meaning as X and X', - B = H, OR4, R4 = H or forms a carbonate or a carbamate with A, - A forms a double bond with C, or - A = OR'4, R'4 = H or forms a carbonate with B <IMAGE> R2 = alk or CONH2, CONHCOR11 or CONHSO2R11, R11 = hydrocarbon up to 18 C, R3 = H, alkyl <IMAGE> Z = H or carboxylic acid residue, and their salts, their preparation and their application as medicaments.
AU87986/91A 1990-11-21 1991-11-20 New erythromycin derivatives, their preparation process, the new intermediates obtained and their use as medicaments Expired AU640290B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR9014499 1990-11-21
FR9014499A FR2669337B1 (en) 1990-11-21 1990-11-21 NOVEL DESCLADINOSYL DERIVATIVES OF ERYTHROMYCIN, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS.
FR9106333 1991-05-27
FR9106333A FR2677025B1 (en) 1991-05-27 1991-05-27 NOVEL DESCLADINOSYL DERIVATIVES OF ERYTHROMYCIN, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS.
FR9110728 1991-08-29
FR9110728A FR2680790B1 (en) 1991-08-29 1991-08-29 NOVEL DESCLADINOSYL DERIVATIVES OF ERYTHROMYCIN, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS.

Publications (2)

Publication Number Publication Date
AU8798691A true AU8798691A (en) 1992-05-28
AU640290B2 AU640290B2 (en) 1993-08-19

Family

ID=27252354

Family Applications (1)

Application Number Title Priority Date Filing Date
AU87986/91A Expired AU640290B2 (en) 1990-11-21 1991-11-20 New erythromycin derivatives, their preparation process, the new intermediates obtained and their use as medicaments

Country Status (26)

Country Link
US (3) US5444051A (en)
EP (1) EP0487411B1 (en)
JP (1) JP3130097B2 (en)
KR (1) KR100189597B1 (en)
CN (1) CN1033974C (en)
AT (1) ATE133683T1 (en)
AU (1) AU640290B2 (en)
BR (1) BR9105062A (en)
CA (1) CA2055912C (en)
CZ (1) CZ290651B6 (en)
DE (1) DE69116815T2 (en)
DK (1) DK0487411T3 (en)
ES (1) ES2082952T3 (en)
FI (1) FI102281B1 (en)
GR (1) GR3018848T3 (en)
HU (1) HU218787B (en)
IE (1) IE74713B1 (en)
IL (3) IL99995A (en)
MA (1) MA22344A1 (en)
MX (1) MX9102159A (en)
NZ (1) NZ240684A (en)
OA (1) OA09523A (en)
PL (2) PL169422B1 (en)
PT (1) PT99569B (en)
RU (1) RU2100367C1 (en)
SK (1) SK281550B6 (en)

Families Citing this family (137)

* Cited by examiner, † Cited by third party
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