AU7894991A - Method of preparation of vaccines, and the use of the vaccines thus prepared - Google Patents
Method of preparation of vaccines, and the use of the vaccines thus preparedInfo
- Publication number
- AU7894991A AU7894991A AU78949/91A AU7894991A AU7894991A AU 7894991 A AU7894991 A AU 7894991A AU 78949/91 A AU78949/91 A AU 78949/91A AU 7894991 A AU7894991 A AU 7894991A AU 7894991 A AU7894991 A AU 7894991A
- Authority
- AU
- Australia
- Prior art keywords
- lytic
- gene
- vaccines
- proteins
- partial sequences
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 7
- 230000002101 lytic effect Effects 0.000 abstract 5
- 241000894006 Bacteria Species 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 101710204837 Envelope small membrane protein Proteins 0.000 abstract 1
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 abstract 1
- 101710145006 Lysis protein Proteins 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- 241001515965 unidentified phage Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Modified bacteria, obtd. by (1) transforming a Gram negative bacterium with (a) the gene of a lytic membrane protein of a bacteriophage, (b) a lytic toxin-release gene or (c) their partial sequences which code for lytic proteins; (2) culturing the bacteria, (3) expressing the lytic genes and (4) isolation from the culture broth, are used as vaccines or adjuvants. - Pref. during culture, activation of the gene is inhibited or expression is repressed, and lifted only at selected times. The lytic gene is the DNA sequence for the E or L proteins (or their membrane-penetrating domains) or the EL-hybrid protein, or their active partial sequences.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4023721A DE4023721A1 (en) | 1990-07-26 | 1990-07-26 | Modified Gram negative bacteria for use as vaccine and adjuvant - are transformed to express lytic protein or toxin, forming ghost(s) which present many cell wall epitope(s) |
| DE4023721 | 1990-07-26 | ||
| PCT/EP1991/000967 WO1992001791A1 (en) | 1990-07-26 | 1991-05-24 | Method of preparation of vaccines, and the use of the vaccines thus prepared |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7894991A true AU7894991A (en) | 1992-02-18 |
| AU656525B2 AU656525B2 (en) | 1995-02-09 |
Family
ID=6411039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU78949/91A Ceased AU656525B2 (en) | 1990-07-26 | 1991-05-24 | Method of preparation of vaccines, and the use of the vaccines thus prepared |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0540525B1 (en) |
| JP (1) | JP3329451B2 (en) |
| AT (1) | ATE184915T1 (en) |
| AU (1) | AU656525B2 (en) |
| DE (2) | DE4023721A1 (en) |
| DK (1) | DK0540525T3 (en) |
| IE (1) | IE911843A1 (en) |
| NZ (1) | NZ238303A (en) |
| WO (1) | WO1992001791A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| DE60232071D1 (en) | 2001-06-11 | 2009-06-04 | Applied Nanosystems Bv | METHOD OF BINDING ACMA-TYPE PROTEIN ANCHOR FUSIONS ON MICRO-ORGANISMS OF CELL WALL MATERIALS |
| DK1524993T3 (en) | 2002-08-02 | 2013-06-03 | Glaxosmithkline Biolog Sa | Neisseria vaccine composition comprising a combination of antigens |
| DE602007003596D1 (en) | 2006-06-12 | 2010-01-14 | Glaxosmithkline Biolog Sa | VACCINE |
| UA99659C2 (en) | 2008-05-30 | 2012-09-10 | Дзе Ю.Ес.Ей., Ес Репрезентед Бай Дзе Секретарі Оф Дзе Армі, Он Бехаф Оф Уолтер Рід Армі | Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof |
| GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
| KR101825439B1 (en) * | 2016-04-15 | 2018-02-05 | 배재대학교 산학협력단 | Method for preparing Gram positive bacteria ghosts by the treatment with hydrochloric acid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2143238A (en) * | 1983-03-31 | 1985-02-06 | Dr Anthony Stuart Breeze | A method for enzyme liberation from bacterial cells |
| US4637980A (en) * | 1983-08-09 | 1987-01-20 | Smithkline Beckman Corporation | Externalization of products of bacteria |
| DE3715840A1 (en) * | 1987-05-12 | 1988-12-01 | Boehringer Mannheim Gmbh | FOR A LYTICALLY EFFECTIVE, CHIMERAL PROTEIN-ENCODING RECOMBINANT DNA AND THEIR USE |
| DE4005874A1 (en) * | 1990-02-24 | 1991-11-07 | Boehringer Mannheim Gmbh | CARRIER-TIED RECOMBINANT PROTEINS, METHOD FOR THE PRODUCTION AND USE AS IMMUNOGENIC AND VACCINE |
-
1990
- 1990-07-26 DE DE4023721A patent/DE4023721A1/en not_active Withdrawn
-
1991
- 1991-05-24 WO PCT/EP1991/000967 patent/WO1992001791A1/en active IP Right Grant
- 1991-05-24 AT AT91909986T patent/ATE184915T1/en not_active IP Right Cessation
- 1991-05-24 DE DE59109155T patent/DE59109155D1/en not_active Expired - Fee Related
- 1991-05-24 JP JP50926591A patent/JP3329451B2/en not_active Expired - Fee Related
- 1991-05-24 EP EP91909986A patent/EP0540525B1/en not_active Expired - Lifetime
- 1991-05-24 DK DK91909986T patent/DK0540525T3/en active
- 1991-05-24 AU AU78949/91A patent/AU656525B2/en not_active Ceased
- 1991-05-29 NZ NZ238303A patent/NZ238303A/en not_active IP Right Cessation
- 1991-05-30 IE IE184391A patent/IE911843A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ238303A (en) | 1993-07-27 |
| WO1992001791A1 (en) | 1992-02-06 |
| AU656525B2 (en) | 1995-02-09 |
| DK0540525T3 (en) | 2000-04-03 |
| EP0540525A1 (en) | 1993-05-12 |
| IE911843A1 (en) | 1992-01-29 |
| JPH06501378A (en) | 1994-02-17 |
| ATE184915T1 (en) | 1999-10-15 |
| JP3329451B2 (en) | 2002-09-30 |
| DE59109155D1 (en) | 1999-10-28 |
| DE4023721A1 (en) | 1992-01-30 |
| EP0540525B1 (en) | 1999-09-22 |
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