[go: up one dir, main page]

AU7879987A - Expression of heterologous proteins by transgenic lactating mammals - Google Patents

Expression of heterologous proteins by transgenic lactating mammals

Info

Publication number
AU7879987A
AU7879987A AU78799/87A AU7879987A AU7879987A AU 7879987 A AU7879987 A AU 7879987A AU 78799/87 A AU78799/87 A AU 78799/87A AU 7879987 A AU7879987 A AU 7879987A AU 7879987 A AU7879987 A AU 7879987A
Authority
AU
Australia
Prior art keywords
expression
heterologous proteins
lactating mammals
transgenic
transgenic lactating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU78799/87A
Inventor
Thomas Patrick Hopp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Publication of AU7879987A publication Critical patent/AU7879987A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU78799/87A 1986-08-28 1987-08-25 Expression of heterologous proteins by transgenic lactating mammals Abandoned AU7879987A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90149086A 1986-08-28 1986-08-28
US901490 1986-08-28

Publications (1)

Publication Number Publication Date
AU7879987A true AU7879987A (en) 1988-03-24

Family

ID=25414282

Family Applications (1)

Application Number Title Priority Date Filing Date
AU78799/87A Abandoned AU7879987A (en) 1986-08-28 1987-08-25 Expression of heterologous proteins by transgenic lactating mammals

Country Status (2)

Country Link
AU (1) AU7879987A (en)
WO (1) WO1988001648A1 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE141646T1 (en) 1986-04-09 1996-09-15 Genzyme Corp GENETICALLY TRANSFORMED ANIMALS THAT SECRETE A DESIRED PROTEIN IN MILK
EP0832981A1 (en) * 1987-02-17 1998-04-01 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
EP0365591A4 (en) * 1987-06-16 1992-01-22 Edison Animal Biotechnology Center Dietary and hormonal regulation of expression of exogenous genes in transgenic animals under control of the promoter of the gene for phosphoenolpyruvate carboxykinase
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
FR2627779B1 (en) * 1988-02-26 1991-03-15 Sodima Union Coop Agricoles PROCESS FOR THICKENING A FERMENTED MILK TYPE PRODUCT, ESPECIALLY YOGURT AND A NEW POLYSACCHARIDE USEFUL FOR THE IMPLEMENTATION OF THIS PROCESS
US6020015A (en) * 1988-09-22 2000-02-01 Gaull; Gerald E. Infant formula compositions and nutrition containing genetically engineered human milk proteins
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5650503A (en) * 1988-11-11 1997-07-22 Ppl Therapeutics (Scotland) Limited Genetic construct of which protein coding DNA comprises introns and is designed for protein production in transgenic animals
GB8826446D0 (en) * 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
US6689610B1 (en) 1989-08-22 2004-02-10 University Of Utah Research Foundation Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
CA2065866A1 (en) * 1989-09-11 1991-03-12 Vermuri B. Reddy Production of growth hormone in transgenic animal milk
AU649407B2 (en) * 1989-09-21 1994-05-26 Infigen, Inc. Enhanced gene expression in response to lactation signals
US5633076A (en) * 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
RU2095414C1 (en) * 1989-12-01 1997-11-10 Джен Фарминг Ойроп БВ Transgene for preparing the recombinant polypeptide in transgenic cow milk, a method of obtaining the transgenic cow (variants), milk from transgenic cow, food composition
JPH04365487A (en) * 1990-04-11 1992-12-17 Consortium Elektrochem Ind Gmbh Recombinant dna structure, recombinant vector, method for obtaining protein from milk of transgenic animal, method for producing transgenic animal and milk of transgenic animal
JPH06507307A (en) * 1991-01-11 1994-08-25 アメリカン・レツド・クロス Expression of active human protein C in mammary gland tissue of transgenic animals
US6984772B1 (en) 1994-02-18 2006-01-10 Virginia Tech Intellectual Properties, Inc. Transgenic non-human mammals producing fibrinogen in their milk
US5831141A (en) * 1991-01-11 1998-11-03 United States Of America As Represented By The Department Of Health And Human Services Expression of a heterologous polypeptide in mammary tissue of transgenic non-human mammals using a long whey acidic protein promoter
US6262336B1 (en) 1991-01-11 2001-07-17 American Red Cross Expression of a heterologous protein C in mammary tissue of transgenic animals using a long whey acidic protein promoter
US5965789A (en) * 1991-01-11 1999-10-12 American Red Cross Engineering protein posttranslational modification by PACE/furin in transgenic non-human mammals
AU663101B2 (en) * 1991-08-13 1995-09-28 Wisconsin Milk Marketing Board DNA sequence encoding bovine alpha-lactalbumin and methods of use
WO1993004171A1 (en) * 1991-08-19 1993-03-04 Symbicom Aktiebolag Human beta-casein, process for producing it and use thereof
GB9119338D0 (en) 1991-09-10 1991-10-23 Inst Of Animal Physiology And Control of gene expression
PT620849E (en) * 1992-01-07 2003-11-28 Elan Pharm Inc TRANSGENIC ANIMAL MODELS FOR ALZHEIMER'S DISEASE
DK8892D0 (en) 1992-01-23 1992-01-23 Symbicom Ab HUMANT PROTEING
AU4537393A (en) * 1992-06-15 1994-01-04 Gene Pharming Europe Bv Production of recombinant polypeptides by bovine species and transgenic methods
US5667839A (en) * 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals
US5856178A (en) * 1993-08-30 1999-01-05 Utah State University DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same
US6204431B1 (en) 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
WO1995024488A1 (en) * 1994-03-09 1995-09-14 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
US5750176A (en) * 1994-03-09 1998-05-12 Abbott Laboratories Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
AU694181B2 (en) * 1994-03-09 1998-07-16 Abbott Laboratories Humanized milk
GB9425326D0 (en) * 1994-12-15 1995-02-15 Ppl Therapeutics Scotland Ltd Gene constructs
SE9403613D0 (en) * 1994-10-21 1994-10-21 Pharmacia Ab Improvement of an expression vector for production of recombinant proteins
US6717031B2 (en) 1995-06-07 2004-04-06 Kate Dora Games Method for selecting a transgenic mouse model of alzheimer's disease
US6077697A (en) 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US7157615B2 (en) 1998-03-17 2007-01-02 Nexia Biotechnologies, Inc. Production of biofilaments in transgenic animals
CN100445379C (en) * 2005-04-21 2008-12-24 李宁 Human alpha-lacto albumin gene transgenic cloned macro domectic animal production method
BR112015019341A2 (en) 2013-02-13 2017-08-22 Lab Francais Du Fractionnement ANTI-TNF-ALPHA ANTIBODY, COMPOSITION COMPRISING THE ANTIBODY, METHOD FOR PRODUCING A POPULATION OF ANTIBODIES, MAMMARY GLAND EPITHELIAL CELLS, TRANSGENIC NON-HUMAN MAMMAL, AND, MONOCLONAL ANTI-TNF ANTIBODY COMPOSITION
AR094778A1 (en) 2013-02-13 2015-08-26 Laboratoire Français Du Fractionnement Et Des Biotechnologies PROTEINS WITH MODIFIED GLYCOSILATION AND METHODS FOR PRODUCERS

Also Published As

Publication number Publication date
WO1988001648A1 (en) 1988-03-10

Similar Documents

Publication Publication Date Title
AU7879987A (en) Expression of heterologous proteins by transgenic lactating mammals
AU557540B2 (en) Preparation of oligomeric aluminoxanes
AU7400391A (en) Method of using bar1 for secreting foreign proteins
AU7486887A (en) Novel procoagulant proteins
AU568540B2 (en) Methods of bonding
AU1482488A (en) Leader sequences for the production of recombinant proteins
AU7873187A (en) Method of culturing leukocytes
AU1491283A (en) Cloning vectors for expression of exogenous protein
AU7474787A (en) Secretion of heterologous proteins from yeast
AU7421787A (en) Production of tertiary olefins
IL74661A0 (en) Preparation of proteins
AU5763686A (en) Hydroformylation of olefins
AU2721884A (en) Yeast homologous signal to secrete heterologous proteins
AU4749685A (en) Mutual separation of proteins
AU536391B2 (en) Fish protein fibres
AU561152B2 (en) Microbially produced rennet using recombinant techniques
AU1168483A (en) Process for the preparation of protein for hydrolysis
NZ216756A (en) Tertiary olefins from alkyl-tertiary alkyl ethers
AU3672984A (en) Ether of n-propanolamine derivative
AU7574187A (en) Induction welding of plastic components
AU1994088A (en) Preparation of novel protein sweeteners-monellin type
PT79853A (en) Process for the preparation of an highly solubilized protein
AU3470189A (en) Antigenic polypeptides of taenia ovis
AU6385886A (en) Production of ige-binding protein by recombinant methods
AU1939788A (en) Preparation of novel protein sweeteners - monellin type