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AU6734296A - Bicyclic lactam derivatives as thrombin inhibitors - Google Patents

Bicyclic lactam derivatives as thrombin inhibitors

Info

Publication number
AU6734296A
AU6734296A AU67342/96A AU6734296A AU6734296A AU 6734296 A AU6734296 A AU 6734296A AU 67342/96 A AU67342/96 A AU 67342/96A AU 6734296 A AU6734296 A AU 6734296A AU 6734296 A AU6734296 A AU 6734296A
Authority
AU
Australia
Prior art keywords
thrombin inhibitors
lactam derivatives
bicyclic lactam
bicyclic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU67342/96A
Inventor
Marco Criscuoli
Fabio Paleari
Aldo Salimbeni
Carlo Scolastico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Menarini Industrie Farmaceutiche Riunite SRL
Original Assignee
A Menarini Industrie Farmaceutiche Riunite SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Menarini Industrie Farmaceutiche Riunite SRL filed Critical A Menarini Industrie Farmaceutiche Riunite SRL
Publication of AU6734296A publication Critical patent/AU6734296A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU67342/96A 1995-08-01 1996-07-18 Bicyclic lactam derivatives as thrombin inhibitors Abandoned AU6734296A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT95MI001688A IT1277405B1 (en) 1995-08-01 1995-08-01 BICYCLIC LACTAM DERIVATIVES AS THROMBIN INHIBITORS
ITMI95A1688 1995-08-01
PCT/EP1996/003167 WO1997005160A1 (en) 1995-08-01 1996-07-18 Bicyclic lactam derivatives as thrombin inhibitors

Publications (1)

Publication Number Publication Date
AU6734296A true AU6734296A (en) 1997-02-26

Family

ID=11372107

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67342/96A Abandoned AU6734296A (en) 1995-08-01 1996-07-18 Bicyclic lactam derivatives as thrombin inhibitors

Country Status (3)

Country Link
AU (1) AU6734296A (en)
IT (1) IT1277405B1 (en)
WO (1) WO1997005160A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
WO1998005333A1 (en) * 1996-08-05 1998-02-12 Molecumetics Ltd. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
WO1998046591A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
AU6896398A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
EP0975659A1 (en) * 1997-04-14 2000-02-02 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
WO1999007730A1 (en) * 1997-08-11 1999-02-18 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS CONTAINING A FUSED AZEPINONE STRUCTURE
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
ES2192764T3 (en) * 1998-02-12 2003-10-16 Molecumetics Ltd MIMETICS OF LAMINA BETA AND METHODS RELATED TO THE USE OF THE SAME.
US6235877B1 (en) * 1999-08-04 2001-05-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
AU3127900A (en) * 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
ITMI20031476A1 (en) * 2003-07-18 2005-01-19 Univ Degli Studi Milano PEPTIDO-MIMETIC COMPOUNDS WITH A AZABICICLOALCANIC STRUCTURE INCLUDING THE RGD SEQUENCE
KR100887045B1 (en) 2004-01-16 2009-03-04 더 리젠츠 오브 더 유니버시티 오브 미시간 Structurally Forced SMC Analogs and Their Uses
JP2007522116A (en) * 2004-01-16 2007-08-09 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Conformationally constrained Smac mimetics and uses thereof
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
TWI696620B (en) * 2014-12-10 2020-06-21 日商小野藥品工業股份有限公司 Dihydroindolizinone derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121947A1 (en) * 1991-07-03 1993-01-07 Basf Ag 2- (3- (4-AMIDINO-PHENYL)) - PROPIONIC ACID DERIVATIVES, THEIR PRODUCTION AND USE
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
AU4250596A (en) * 1994-12-22 1996-07-10 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors

Also Published As

Publication number Publication date
ITMI951688A0 (en) 1995-08-01
WO1997005160A1 (en) 1997-02-13
IT1277405B1 (en) 1997-11-10
ITMI951688A1 (en) 1997-02-01

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