AU6728781A - Microbiologically prepared polypeptide with the aminoacid sequence of human interferon - Google Patents
Microbiologically prepared polypeptide with the aminoacid sequence of human interferonInfo
- Publication number
- AU6728781A AU6728781A AU67287/81A AU6728781A AU6728781A AU 6728781 A AU6728781 A AU 6728781A AU 67287/81 A AU67287/81 A AU 67287/81A AU 6728781 A AU6728781 A AU 6728781A AU 6728781 A AU6728781 A AU 6728781A
- Authority
- AU
- Australia
- Prior art keywords
- polypeptide
- interferon
- human interferon
- aminoacid sequence
- cdna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000014150 Interferons Human genes 0.000 title abstract 4
- 108010050904 Interferons Proteins 0.000 title abstract 4
- 229940079322 interferon Drugs 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 125000003275 alpha amino acid group Chemical group 0.000 title abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 2
- 239000002299 complementary DNA Substances 0.000 abstract 2
- 210000002950 fibroblast Anatomy 0.000 abstract 2
- 239000013612 plasmid Substances 0.000 abstract 2
- 241001646716 Escherichia coli K-12 Species 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
There is utilised recombinant DNA technology in the production of interferon, which provides a microbiologically produced polypeptide, all or part of which comprises the amino acid sequence of human interferon, especially fibroblast (???) interferon. There is also provided CDNA which codes for such a polypeptide; a plasmid, especially plasmid pBR 322, which comprises the cDNA; and a microorganism, for example Escherichia coli, especially E. coli K12 or E. coli X1776, which comprises the genetic information required for the production of such a polypeptide. The cDNA is preferably prepared using mRNA obtained from human fibroblasts.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803005843 DE3005843A1 (en) | 1980-02-16 | 1980-02-16 | GENERAL PRODUCT OF A HIGHER ORGANISM FROM A MICROORGANISM CONTAINING THIS GENE |
| DE30058436 | 1980-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU6728781A true AU6728781A (en) | 1981-08-27 |
Family
ID=6094790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU67287/81A Abandoned AU6728781A (en) | 1980-02-16 | 1981-02-13 | Microbiologically prepared polypeptide with the aminoacid sequence of human interferon |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0034306B1 (en) |
| JP (1) | JPS56131522A (en) |
| AT (1) | ATE26999T1 (en) |
| AU (1) | AU6728781A (en) |
| BE (1) | BE887530A (en) |
| DE (2) | DE3005843A1 (en) |
| ES (3) | ES8205430A1 (en) |
| FR (1) | FR2482132A1 (en) |
| GB (1) | GB2069504A (en) |
| IT (1) | IT1141976B (en) |
| NL (1) | NL8100719A (en) |
| SE (1) | SE8101004L (en) |
| ZA (1) | ZA81973B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK33181A (en) * | 1980-02-06 | 1981-08-07 | Searle & Co | PROCEDURE FOR THE PREPARATION OF AN INTERFERONOUS PROTEIN |
| AU564690B2 (en) * | 1980-04-03 | 1987-08-20 | Biogen Idec Ma Inc. | Process for producing human fibroblast interferon-like polypeptides using recombinant dna |
| DE3176011D1 (en) * | 1980-06-12 | 1987-04-23 | Japan Found Cancer | Plasmid |
| IT1139487B (en) * | 1980-09-25 | 1986-09-24 | Genentech Inc | MICROBIAL PRODUCTION OF HUMAN FIBROBLAST INTERFERON |
| WO1983002461A1 (en) * | 1982-01-19 | 1983-07-21 | Cetus Corp | Multiclass hybrid interferons |
| IE54592B1 (en) * | 1982-03-08 | 1989-12-06 | Genentech Inc | Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby |
| US5827694A (en) * | 1982-03-08 | 1998-10-27 | Genentech, Inc. | DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides |
| US6432677B1 (en) | 1982-03-08 | 2002-08-13 | Genentech, Inc. | Non-human animal interferons |
| DE3220116A1 (en) * | 1982-05-28 | 1983-12-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | MICROBIOLOGICALLY MANUFACTURED (ALPHA) AND SS INTERFERONES, DNA SEQUENCES CODING FOR THESE INTERFERONES, MICROORGANISMS CONTAINING THIS GENETIC INFORMATION, AND METHOD FOR THE PRODUCTION THEREOF |
| US5831023A (en) * | 1982-11-01 | 1998-11-03 | Genentech, Inc. | Recombinant animal interferon polypeptides |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI77877C (en) * | 1979-04-20 | 1989-05-10 | Technobiotic Ltd | Process for the preparation and purification of human Le-shaped interferon protein. |
| AU538665B2 (en) * | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
| IL58765A (en) * | 1979-11-21 | 1986-09-30 | Yeda Res & Dev | Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta |
| NO164037C (en) * | 1980-01-08 | 1990-08-22 | Biogen Inc | PROCEDURE FOR PREPARING A POLYPEPTIDE OF INTERFERON ALFA (IFNALFA) TYPE. |
| DK33181A (en) * | 1980-02-06 | 1981-08-07 | Searle & Co | PROCEDURE FOR THE PREPARATION OF AN INTERFERONOUS PROTEIN |
| AU545912B2 (en) * | 1980-03-10 | 1985-08-08 | Cetus Corporation | Cloned heterologous jive products in bacillies |
| AU564690B2 (en) * | 1980-04-03 | 1987-08-20 | Biogen Idec Ma Inc. | Process for producing human fibroblast interferon-like polypeptides using recombinant dna |
-
1980
- 1980-02-16 DE DE19803005843 patent/DE3005843A1/en not_active Withdrawn
-
1981
- 1981-02-05 EP EP81100802A patent/EP0034306B1/en not_active Expired
- 1981-02-05 DE DE8181100802T patent/DE3176161D1/en not_active Expired
- 1981-02-05 AT AT81100802T patent/ATE26999T1/en not_active IP Right Cessation
- 1981-02-10 ES ES499290A patent/ES8205430A1/en not_active Expired
- 1981-02-10 ES ES499285A patent/ES8302089A1/en not_active Expired
- 1981-02-10 ES ES499289A patent/ES499289A0/en active Granted
- 1981-02-13 SE SE8101004A patent/SE8101004L/en not_active Application Discontinuation
- 1981-02-13 AU AU67287/81A patent/AU6728781A/en not_active Abandoned
- 1981-02-13 NL NL8100719A patent/NL8100719A/en not_active Application Discontinuation
- 1981-02-13 IT IT19759/81A patent/IT1141976B/en active
- 1981-02-13 ZA ZA00810973A patent/ZA81973B/en unknown
- 1981-02-16 GB GB8104763A patent/GB2069504A/en not_active Withdrawn
- 1981-02-16 FR FR8102963A patent/FR2482132A1/en active Pending
- 1981-02-16 BE BE0/203804A patent/BE887530A/en not_active IP Right Cessation
- 1981-02-16 JP JP2130781A patent/JPS56131522A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES8205429A1 (en) | 1982-06-01 |
| ES499290A0 (en) | 1982-06-01 |
| ATE26999T1 (en) | 1987-05-15 |
| ES499285A0 (en) | 1983-01-01 |
| ZA81973B (en) | 1982-03-31 |
| BE887530A (en) | 1981-08-17 |
| GB2069504A (en) | 1981-08-26 |
| EP0034306B1 (en) | 1987-05-06 |
| JPS56131522A (en) | 1981-10-15 |
| FR2482132A1 (en) | 1981-11-13 |
| EP0034306A3 (en) | 1981-11-04 |
| DE3176161D1 (en) | 1987-06-11 |
| DE3005843A1 (en) | 1981-09-10 |
| NL8100719A (en) | 1981-09-16 |
| ES499289A0 (en) | 1982-06-01 |
| ES8205430A1 (en) | 1982-06-01 |
| EP0034306A2 (en) | 1981-08-26 |
| IT1141976B (en) | 1986-10-08 |
| SE8101004L (en) | 1981-08-17 |
| IT8119759A0 (en) | 1981-02-13 |
| ES8302089A1 (en) | 1983-01-01 |
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