AU664212B2 - Quinoxaline derivates with affinity for quisqualate-receptors - Google Patents

Quinoxaline derivates with affinity for quisqualate-receptors

Info

Publication number: AU664212B2
Authority: AU; Australia
Prior art keywords: quisqualate; receptors; affinity; derivates; quinoxaline
Prior art date: 1991-10-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU28894/92A

Other languages

English (en)

Other versions

AU2889492A (en

Inventor

Ilse Beetz

Peter Holscher

Andreas Huth

Martin Kruger

Peter Andreas Loschmann

Dieter Rahtz

Ralph Schmiechen

Ingrid Schumann

Dieter Seidelmann

David Norman Stephens

Lechoslaw Turski

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-26

Filing date

1992-10-25

Publication date

1995-11-09

1991-10-26 Priority claimed from DE4135871A external-priority patent/DE4135871A1/de

1992-10-25 Application filed by Schering AG filed Critical Schering AG

1993-05-21 Publication of AU2889492A publication Critical patent/AU2889492A/en

1995-11-09 Application granted granted Critical

1995-11-09 Publication of AU664212B2 publication Critical patent/AU664212B2/en

2012-10-25 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Emergency Medicine (AREA)
Psychology (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AU28894/92A 1991-10-26 1992-10-25 Quinoxaline derivates with affinity for quisqualate-receptors Ceased AU664212B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DE4135871A DE4135871A1 (de)	1991-10-26	1991-10-26	Chinoxalinderivate, deren herstellung und verwendung in arzneimitteln
DE4135871		1991-10-26
DE4224200		1992-07-17
DE4224200		1992-07-17
PCT/DE1992/000895 WO1993008173A1 (de)	1991-10-26	1992-10-25	Chinoxalin-derivate, mit affinität an die quisqualat-rezeptoren

Publications (2)

Publication Number	Publication Date
AU2889492A AU2889492A (en)	1993-05-21
AU664212B2 true AU664212B2 (en)	1995-11-09

Family

ID=25908683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU28894/92A Ceased AU664212B2 (en)	1991-10-26	1992-10-25	Quinoxaline derivates with affinity for quisqualate-receptors

Country Status (17)

Country	Link
EP (1)	EP0565683A1 (zh)
JP (1)	JP3258008B2 (zh)
KR (1)	KR100262371B1 (zh)
CN (1)	CN1038840C (zh)
AU (1)	AU664212B2 (zh)
CA (1)	CA2099270A1 (zh)
CZ (1)	CZ286351B6 (zh)
FI (1)	FI932959A0 (zh)
HU (1)	HUT64756A (zh)
IL (1)	IL103538A (zh)
NO (1)	NO304693B1 (zh)
NZ (1)	NZ244896A (zh)
PL (1)	PL171125B1 (zh)
PT (1)	PT101004B (zh)
RU (1)	RU2117663C1 (zh)
SK (1)	SK281518B6 (zh)
WO (1)	WO1993008173A1 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK162491D0 (da) *	1991-09-20	1991-09-20	Novo Nordisk As	Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne
DK0647137T3 (da) *	1992-06-22	2008-12-08	State Of Oregon Through Oregon	Glycinreceptorantagonister og anvendelse deraf
DE4314592A1 (de) *	1993-04-28	1994-11-03	Schering Ag	Benzo(f)chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
IL109397A0 (en) *	1993-04-28	1994-07-31	Schering Ag	Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE4428152A1 (de) *	1994-06-22	1996-01-04	Basf Ag	Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung
GB9419318D0 (en) *	1994-09-24	1994-11-09	Pfizer Ltd	Therapeutic agents
CN1067387C (zh) *	1994-09-27	2001-06-20	山之内制药株式会社	1,2,3,4－四氢喹喔啉二酮衍生物
DE4439493A1 (de) *	1994-10-25	1996-05-02	Schering Ag	Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE4439492A1 (de) *	1994-10-25	1996-05-02	Schering Ag	Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
US6110911A (en) *	1995-06-07	2000-08-29	Warner-Lambert Company	Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
DE19521058A1 (de) *	1995-06-09	1996-12-12	Basf Ag	Verfahren zur Herstellung von Aromaten enthaltenden Polyetherpolyolen
DE19545251A1 (de) *	1995-11-24	1997-05-28	Schering Ag	Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
TW448171B (en) *	1996-06-06	2001-08-01	Yamanouchi Pharma Co Ltd	Imidazole-substituted quinoxalinedione derivatives
DE19624808A1 (de)	1996-06-21	1998-01-02	Basf Ag	Pyrrolylchinoxalindione, ihre Herstellung und Verwendung
DE19728326A1 (de) *	1997-06-27	1999-01-07	Schering Ag	Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
US6015800A (en) *	1997-09-03	2000-01-18	Warner-Lambert Company	Substituted quinoxaline-2-ones as glutamate receptor antagonists
IL125950A0 (en) *	1997-09-05	1999-04-11	Pfizer Prod Inc	Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
EP0900567A3 (en) *	1997-09-05	2001-05-02	Pfizer Products Inc.	Quinazoline-4-one AMPA antagonists for the treatment of dyskinesias associated with dopamine agonist therapy
FR2769309B1 (fr)	1997-10-08	2001-06-15	Oreal	Composition de teinture d'oxydation des fibres keratiniques comprenant un derive d'aminoacide en tant que base d'oxydation et nouveaux derives d'aminoacides
GB0311406D0 (en) *	2003-05-17	2003-06-25	Queen Mary & Westfield College	Substituted phosphonate fluorescent sensors,and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7576791A (en) *	1990-03-16	1991-10-10	Novo Nordisk A/S	Quinoxaline compounds and their preparation and use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0118982A1 (en) *	1983-02-01	1984-09-19	Sumitomo Chemical Company, Limited	Organic phosphorous quinoxalinone and their production and use
NO179551C (no) *	1987-11-10	1996-10-30	Novo Nordisk As	Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser

1992
- 1992-10-23 PT PT101004A patent/PT101004B/pt not_active IP Right Cessation
- 1992-10-25 RU RU93044489A patent/RU2117663C1/ru active
- 1992-10-25 IL IL10353892A patent/IL103538A/en not_active IP Right Cessation
- 1992-10-25 JP JP50735393A patent/JP3258008B2/ja not_active Expired - Fee Related
- 1992-10-25 WO PCT/DE1992/000895 patent/WO1993008173A1/de not_active Application Discontinuation
- 1992-10-25 AU AU28894/92A patent/AU664212B2/en not_active Ceased
- 1992-10-25 PL PL92299929A patent/PL171125B1/pl unknown
- 1992-10-25 CA CA002099270A patent/CA2099270A1/en not_active Abandoned
- 1992-10-25 KR KR1019930701948A patent/KR100262371B1/ko not_active IP Right Cessation
- 1992-10-25 HU HU9301877A patent/HUT64756A/hu unknown
- 1992-10-25 SK SK727-93A patent/SK281518B6/sk unknown
- 1992-10-25 CZ CZ19931387A patent/CZ286351B6/cs not_active IP Right Cessation
- 1992-10-25 EP EP92922676A patent/EP0565683A1/de not_active Withdrawn
- 1992-10-26 CN CN92113338A patent/CN1038840C/zh not_active Expired - Fee Related
- 1992-10-27 NZ NZ244896A patent/NZ244896A/en unknown
1993
- 1993-06-24 FI FI932959A patent/FI932959A0/fi unknown
- 1993-06-25 NO NO932116A patent/NO304693B1/no not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7576791A (en) *	1990-03-16	1991-10-10	Novo Nordisk A/S	Quinoxaline compounds and their preparation and use

Also Published As

Publication number	Publication date
CZ286351B6 (cs)	2000-03-15
NO304693B1 (no)	1999-02-01
KR100262371B1 (ko)	2000-08-01
HUT64756A (en)	1994-02-28
WO1993008173A1 (de)	1993-04-29
RU2117663C1 (ru)	1998-08-20
NO932344D0 (no)	1993-06-25
PL299929A1 (en)	1994-04-05
PL171125B1 (pl)	1997-03-28
NZ244896A (en)	1995-07-26
FI932959A (fi)	1993-06-24
CN1072929A (zh)	1993-06-09
FI932959A0 (fi)	1993-06-24
JP3258008B2 (ja)	2002-02-18
CN1038840C (zh)	1998-06-24
SK72793A3 (en)	1993-10-06
SK281518B6 (sk)	2001-04-09
IL103538A (en)	2001-07-24
AU2889492A (en)	1993-05-21
IL103538A0 (en)	1993-03-15
HU9301877D0 (en)	1993-09-28
CA2099270A1 (en)	1993-04-27
CZ138793A3 (en)	1994-01-19
JPH06503583A (ja)	1994-04-21
KR930703271A (ko)	1993-11-29
NO932344L (no)	1993-06-25
PT101004A (pt)	1994-01-31
EP0565683A1 (de)	1993-10-20
PT101004B (pt)	1999-10-29

Publication	Publication Date	Title
AU664212B2 (en)	1995-11-09	Quinoxaline derivates with affinity for quisqualate-receptors
AU2248992A (en)	1993-01-25	Connector block assembly
AU2454992A (en)	1993-04-08	Dispersions
AU2447492A (en)	1993-03-02	User-propelled vehicle
AU1823492A (en)	1992-12-24	Imidazodiazepines
AU1062792A (en)	1992-08-06	Turntable
AU1782292A (en)	1992-10-21	Gridbeam
AU1556892A (en)	1992-09-15	2-substituted-2-imidazolines
AU1908892A (en)	1993-02-11	Assembly apparatus
AU4760193A (en)	1994-03-03	Antioxidant
AU1080292A (en)	1992-08-13	Ige-receptor-antibodies
AU1432092A (en)	1992-09-15	Quinoxaline phosphono-amino acids
AU657142B2 (en)	1995-03-02	Dithianes
AU3712589A (en)	1991-02-07	Polyethyleneimine matrixes for affinity chromatography
AU1752492A (en)	1992-11-17	Diamino-alpha-alkylstilbenes
AU1732692A (en)	1992-12-10	Substituted imidazolinylpyrimidines
AU7138791A (en)	1991-08-29	Skip
AU1116692A (en)	1992-08-27	Lampholder
AU1624092A (en)	1992-11-19	Mopheads
AU1588892A (en)	1992-11-02	Watch-strap
AU1669792A (en)	1992-11-17	Azabicycloheptanone
AU3033592A (en)	1993-06-24	Shuttlecar equaliser
AU1581092A (en)	1992-11-17	Nystagmograph
AU1130292A (en)	1992-09-03	Peptid-analoga
AU3092492A (en)	1993-07-19	Slide assembly

Legal Events

Date	Code	Title	Description
2003-05-29	MK14	Patent ceased section 143(a) (annual fees not paid) or expired