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AU6505294A - New carboxylic-acid esters of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, the preparation of such esters and their use - Google Patents

New carboxylic-acid esters of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, the preparation of such esters and their use

Info

Publication number
AU6505294A
AU6505294A AU65052/94A AU6505294A AU6505294A AU 6505294 A AU6505294 A AU 6505294A AU 65052/94 A AU65052/94 A AU 65052/94A AU 6505294 A AU6505294 A AU 6505294A AU 6505294 A AU6505294 A AU 6505294A
Authority
AU
Australia
Prior art keywords
esters
propoxymethyl
purine
dihydroxy
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU65052/94A
Inventor
Gerhard Gross
Matthias Helsberg
Gerhard Jahne
Thomas Scholl
Irvin Winkler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU6505294A publication Critical patent/AU6505294A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention concerns compounds of formula (1) in which the substituents R<1> and R<2> are as defined in the description. Such compounds exhibit an antiviral action and high bio-availability following oral administration.
AU65052/94A 1993-04-09 1994-03-24 New carboxylic-acid esters of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, the preparation of such esters and their use Abandoned AU6505294A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4311801A DE4311801A1 (en) 1993-04-09 1993-04-09 New carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use
DE4311801 1993-04-09
PCT/EP1994/000951 WO1994024134A1 (en) 1993-04-09 1994-03-24 New carboxylic-acid esters of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, the preparation of such esters and their use

Publications (1)

Publication Number Publication Date
AU6505294A true AU6505294A (en) 1994-11-08

Family

ID=6485206

Family Applications (1)

Application Number Title Priority Date Filing Date
AU65052/94A Abandoned AU6505294A (en) 1993-04-09 1994-03-24 New carboxylic-acid esters of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, the preparation of such esters and their use

Country Status (9)

Country Link
EP (1) EP0693071B1 (en)
JP (1) JPH08508508A (en)
AT (1) ATE161011T1 (en)
AU (1) AU6505294A (en)
DE (2) DE4311801A1 (en)
DK (1) DK0693071T3 (en)
ES (1) ES2111297T3 (en)
GR (1) GR3025797T3 (en)
WO (1) WO1994024134A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9800452D0 (en) * 1998-02-13 1998-02-13 Medivir Ab antivirals
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
CA2271135A1 (en) * 1996-11-12 1998-05-22 Medivir Ab Nucleosides
CN1130362C (en) * 1997-08-15 2003-12-10 美迪维尔公司 Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the DNA polymerase of hepatitis B virus (HBV)
WO1999032490A1 (en) * 1997-12-19 1999-07-01 Bristol-Myers Squibb Company Prodrugs of lobucavir and methods of use
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4008858A1 (en) * 1990-03-20 1991-09-26 Hoechst Ag New substd. purine antiviral cpds.
DE4210221A1 (en) * 1992-03-28 1993-09-30 Hoechst Ag Carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use

Also Published As

Publication number Publication date
GR3025797T3 (en) 1998-03-31
DE4311801A1 (en) 1994-10-13
WO1994024134A1 (en) 1994-10-27
DE59404784D1 (en) 1998-01-22
JPH08508508A (en) 1996-09-10
ES2111297T3 (en) 1998-03-01
EP0693071A1 (en) 1996-01-24
DK0693071T3 (en) 1998-08-10
EP0693071B1 (en) 1997-12-10
ATE161011T1 (en) 1997-12-15

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