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AU640560B2 - Closure for reagent container - Google Patents

Closure for reagent container Download PDF

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Publication number
AU640560B2
AU640560B2 AU12933/92A AU1293392A AU640560B2 AU 640560 B2 AU640560 B2 AU 640560B2 AU 12933/92 A AU12933/92 A AU 12933/92A AU 1293392 A AU1293392 A AU 1293392A AU 640560 B2 AU640560 B2 AU 640560B2
Authority
AU
Australia
Prior art keywords
closure
wall
angle
side wall
symmetry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU12933/92A
Other versions
AU1293392A (en
Inventor
Rudolf Bucheli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU1293392A publication Critical patent/AU1293392A/en
Application granted granted Critical
Publication of AU640560B2 publication Critical patent/AU640560B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00435—Refrigerated reagent storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/03—Medical

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Closures For Containers (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Description

A
840560
AUSTRALIA
PATENTS ACT 1990 COMPLETE SPECIFICATION S F Ref: 204183 FOR A STANDARD PATENT
ORIGINAL
*0 OS 00 S 0
S
0000 00 Name and Address of Applicant: Actual Inventor(s): Address for Service: Invention Title: F.Hoffmann-La Roche AG 124 Grenzacherstrasse CH-4002, Basel
SWITZERLAND
Rudolf Bucheli Spruson Ferguson, Patent Attorneys Level 33 St Martins Tower, 31 Market Street Sydney, New South Wales, 2000, Australia Closure for Reagent Container 6000 o* 0
O
0 5 00 0 The following statement is a full description of this invention, including the best method of performing it known to me/us:- 5845/8 RAN 4090/217 The invention relates to a closure for a reagent container for use in an analysis system in which an automatic pipetting device is used for transferring small quantities of reagent from the reagent container to reaction cells.
The invention also relates to a closure device containing a closure of the aforerinentioned kind.
In hitherto-known analysis systems, e.g. for clinical chemical analysis of biological specimens, open reagent containers are used.
An automatic pipetting device takes a small amount of a liquid 15 reagent from the container and supplies it to a reaction cell. In •each pipetting operation, an electromechanically driven arm guides the needle of the pipetting device to a reagent container, guides it o in the container so as to remove a volume of reagent, lifts the needle out of the container and guides it to the reaction vessel to 20 which the volume of reagent is to be supplied.
The capacity of a conventional reagent container is sufficient for a relatively large number (of the order of 20 to 2000) of such pipetting operations.
The use of open reagent containers has the following disadvantages: The laboratory staff have to take each new reagent container see* 30 out if its packaging, remove the closure and insert the open reagent container into the analysis system in place of an empty reagent container. Often a number of different reagents are needed at different times in the same analysis system. The use of open reagent containers therefore puts the laboratory staff to considerable trouble, because it demands from the staff a considerable amount of work.
When open reagent containers are used in rooms with relatively dry air, some of the reagent solution is lost through Ve/8.1.92 evaporation and consequently the concentration of the reagent increases with time. When open reagent containers are used in rooms with relatively moist air, on the other hand, or when water condenses during the use of cooled reagents, the volume of the reagent solution increases and thus its concentration decreases with time. When open reagent containers are used, there is also exchange of gas with the ambient air, and this exchange causes ageing, respectively changes of the reagent. All the aforementioned changes in the reagent, particularly in the concentration thereof, reduce the accuracy of the resulting analysis. In order to obviate this at least partly, the entire reagent container has hitherto been enclosed in relatively complicated packaging.
The object of the invention therefore is to provide a closure of the initiallymentioned kind for obviating the aforementioned disadvantages According to a first embodiment of the present invention there is provided a closure for a reagent container for use in an analysis system with an automatic pipetting device having a pipetting needle for transferring small quantities of reagent from the reagent i' container to a reaction cell, the closure being characterized in that it comprises: a) an outer cylindrical side wall having an inner and an outer surface and having an axis of symmetry parallel to the side wall; b) an annular top wall adjacent to the side wall and having a circular aperture; and c) an inner conical wall with an inner and outer surface adjacent to the top wall tapering inwardly from the aperture in the top wall and away from the side wall along the axis of symmetry, and ending at a pointed tip configured and proportioned to be piercable by the pipetting needle, the closure being formed as a single piece of plastic material.
The main advantages of the closure according to the invention are as follows: 2 For the purpose of pipetting a reagent from the container into the reaction cells, the 25 pipetting needle can be inserted through the closure into the reagent container, it is therefore unnecessary to remove the closure in order to use the container in an analysis system.
:"In each pipetting process, the conical inwardly extending wall in the central part of S: the closure guides the pipetting needle 00oo 0.10_ IPriv21\00099:KEH 2 of 4 -3through the same place in the closure, i.e. through a small slot in the perforated tip of the conical wall. This ensures that even after a large number of pipetting operations 200 to 1000) through the same closure, there is no danger of damage to the closure and no resulting blockage of the pipetting needle by fragments of the closure).
Apart from small venting slots, which are open only when the pipetting needle is inserted, the reagent container equipped with the closure according to the invention remains substantially sealed during its entire period of use in the analysis system. This effect of the closure according to the invention is obtained more particularly as a result of its conical wall, which has a shape and length so as to i prevent evaporation of the reagent solution, and exchange of gas 15 with the ambient air, and thereby prevents premature ageing of t' .the reagent. In addition, the closure surrounds and re-iliently abuts the pipetting needle at the place of penetration. As a result, the needle is wiped when inserted and pulled out, thus largely 60I6 preventing contamination by different reagents.
As a r;esult of the aforementioned advantages, by means of the closure /according to the invention the treatment of the reagent -container in the analysis system can be made automatic, i.e. the laboratory staff can be relieved from the hitherto necessary manual activity and the reliability of. treatment can also be increased.
The closure according to the invention is preferably a screw cap. This is a simple method of ensuring a efficient seal on the reagent container.
A preferred embodiment of the closure according to the invention is characterized in that the conical wall has a first part which is adjacent to the top wall and which forms a first angle with the axis of symmetry of the cylindrical side wall, and a second part which forms the tip of the conical wall and which forms a second angle with the axis of symmetry of the cylindrical side wall, said second angle being larger than the first angle. The first angle is preferably between 50 and 30° and the second angle is preferably between 20° and In a particularly preferred embodiment the first angle is about 10° and the second angle is about 30°. By this means the conical wall of the closure serves a double purpose in optimum manner, i.e. as a guide for inserting the pipetting needle and as an important part of the closure for tightly sealing the container.
Preferably, access to the conical wall of the closure according to the invention is sealed by a metal sealing foil. As a result the closure has sufficient sealing-tightness for storing freeze-dried or granulated reagents for a prolonged period.
A preferred embodiment of the closure according to the invention is characterized in that it has an annular sealing lip adjacent the top wall, the lip being concentric with the side wall and extending inwards and lying between the side wall and the conical wall.
This embodiment of the closure has the advantage that it obviates the need for an additional sealing ring between the closure and the container. This embodiment of the closure is particularly suitable for storing reagents in liquid form, because it provides sufficient sealing-tightness over a protracted period of time.
According to a second embodiment of the present invention there is provided a closure device for a reagent container for use in an analyfis system with an automatic pipetting device having a pipetting needle for transferring small quantities of at least one reagent from the reagent container to a reaction cell, the closure device being characterized in that it comprises: a) a closure comprising an outer cylindrical side wall having an inner and an outer surface and having an axis of symmetry parallel to the side wall, an annular top wall adjacent to the side wall and having a circular aperture, an inner conical wall with an :inner and outer surface adjacent to the top wall tapering inwardly from the aperture in the 25 op wall and away from the side wall along the axis of symmetry, and ending at a pointed lip configured and proportioned to be piercable by the pipetting needle, the closure being formed as a single piece of plastic material, and b) a plug configured and proportioned to be insertable between the cap and the container, said plug having a central orifice with an inner wall configured to abut the outer surface of the conical wall in a sealing manner.
*4 ••ooe ^I
F
nDO° 9 4 ot 4 when thp -ontain.r is sealed hy th, g- and the CIOnnr, the outer surface of the ccau aabuts in sealing-tight manner against the g othe orifice through the closure.
Since this closure device contains a closure according to the invention, it provides all the advantages described hereinbefore with reference to the closure. The plug provided in the closure means according to the invention increases the sealing-tightness.
This is particularly advantageous for containers holding reagents in granulated form. Preferably all the previously-mentioned embodiments of the closure according to the invention can be used in the closure device according to the invention, except for that embodiment of the closure according to the invention which has an annular sealing lip adjacent the top wall.
S
e* An embodiment of the invention will now be described with reference to the accompanying drawings, in which: @*ose: Fig. 1 is a view, partly in section, of a first embodiment of a closure 11 according to the invention; Fig. 2 is a partial top plan view of the closure 11 in Fig. 1; Fig. 3 is a cross-section of a plug 21 adapted to co-operate with the closure 11 in Fig. 1 to form a closure device according to the invention; Fig. 4 is a view, partly in cross-section, of a closure device 1. according to the invention; Fig. 5 is a view, partly in cross-section, of the closure device as per Fig. 1 and a spike 17 inserted therein; Fig. 6 is a view, partly in cross-section, of the closure device in Fig. 4 after removal of the spike 17 shown in Fig. Fig. 7 is a top plan view of the closure device in Fig. 6; v ii i 1 V:-2k u -6- Fig. 8 is a view, partly in cross-section, of the closure device in Fig. 4 and a pipetting needle 26 inserted thereinto, and Fig. 9 is a view, partly in cross-section, of a second embodiment of a closure 31 according to the invention.
A first embodiment of a closure 11 according to the invention will now be described with reference Figs. 1 and 2. The closures 11 is made in one piece from a plastic. It has a cylindrical side wall 13 and an annular top wall 14 adjacent the side wall and merging into a conical wall 15 which extends inwards from the inner circle of the top wall and ends in a piercable tip 16 which lies on the axis of symmetry of the cylindrical wall, said tip being apt to be pierced e.g. by the pipetting needle of an automatic pipetting device.
S
Preferal;i the closure 11 is a screw cap having a side wall 13 formed with an internal thread 19 which matches an outer thread in the neck of the reagent container (not shown) which is to be sealed by the closure.
The conical wall 15 has a first part which is adjacent to the top wall 14 and which forms a first angle with the axis of symmetry of the cylindrical side wall. This first angle is preferably about 100 but can be between 50 and 300.
The conical wall 15 has a second part which forms the tip 16 of the conical wall and which forms a second angle with the axis of symmetry of the cylindrical side wall 13. This second angle is greater than the first angle. The second angle is preferably about 30 300, but can be between 200 and 600.
Access to the conical wall 15 is preferably sealed by a metal sealing foil 28. An embodiment thereof is shown in Fig. 4.
Fig. 3 shows a cross-section through a plug 21 which, in cooperation with the closure 11 in Fig. 1, is adapted to form a closure device according to the invention as in Fig. 4, for providing a particularly good seal.
-7- As Fig. 4 shows, the closure device comprises the previouslydescribed closure 11 and the plug 21, which is insertable as a seal between the closure 11 and the container. The plug 21 has a central orifice 22 which is shaped to match the outer surface of the conical wall 15 of the closure so that when the container is sealed by the plug 21 and closure 11, the outer surface of the conical wall bears in sealing-tight manner against the inner wall of the orifice 22 through the plug 21.
All the embodiments of the closure 11 described with reference to Figs. 1 4 hereinbefore are suitable for constructing the closure device which has likewise been described.
The use of the closure 11 will be described hereinafter with reference to Figs. 5 8.
.I The tip 16 of the conical wall 15 in Fig. 1 is pierced by the tip of a spike 17, which has cutting fins 18, 19. The sharp bottom edges of the fins 18, 19 cut venting slots in the bottom part of the conical wall 15. After the spike 17 has been removed, the conical wall 15 remains in the state shown in Figs. 6 and 7. A Y-shaped slot 23 is left at the perforated tip of wall 15. and the bottom part of the wall now has venting slots 24 and As shown in Fig. 8, a pipetting needle can now be introduced through the Y-shaped slot at the tip of the conical wall 15 into the reagent container, e.g. in order to remove a given volume of liquid reagent therefrom.
Fig. 9 shows another embodiment of a closure 31 according to the invention which by itself, i.e. without an additional plug such as the plug 21 in Fig. 4, provides sufficient sealing-tightness for storing a realgent in a container. As before, the closure 31 is made in one piece from a plastic. It has a cylindrical side wall 33 and an annular wall 34 adjacent the side wall and merging into a conical wall 35. The wall 35 extends inwards from the inner circle of the top wall 34 and ends in a piercable tip 36 lying on the axis of -8symmetry of the cylindrical wall 33. The plug axis of symmetry of the cylindrical wall 33. The plug 31 also has an annular sealing lip adjacent the top wall 34, the lip being concentric with the side wall 33, extending inwards and lying between the side wall 33 and the conical wall 35. The embodiment in Fig. 9 is particularly suitable for storing a liquid gent, e.g. when the required degree of sealing-tightness is not very high.' Alternatively, the embodiment in Fig. 4 can be used to store a reagent in dry form granulated or freeze-dried), if the required degree of sealing-tightness is ensured by the construction of the closure and particularly by the thickness of its walls.
The use of the closure 11 described with reference to Fig. to 8 also applies to the closure 31 in Fig. 9.
The closure 11 or 31 is made by injection moulding, e.g. from LD-PE (low density polyethylene). The closure is given a suitable colour, e.g. white.
The plug 21 is made e.g. of bromobutyl rubber.
The sealing foil 28 is e.g. a sandwich foil, i.e. a laminated :structure comprisiag a layer of polyethylene terephthalate (PETP) having a thickness of f2 micrometres, an aluminium layer having a thickness of 12 micrometres and a layer of polyethylene (PE) ahaving a thickness of 100 micrometres.
0 o..

Claims (14)

1. A closure for a reagent container for use in an analysis system with an automatic pipetting device having a pipetting needle for transferring small quantities of reagent from the reagent container to a reaction cell, the closure being characterized in that it comprises: a) an outer cylindrical side wall having an inner and an cuter surface and having an axis of symmetry parallel to the side wall; b) an annular top wall adjacent to the side wall and having a circular aperture; and c) an inner conical wall with an inner and outer surface adjacent to the top wall tapering inwardly from the aperture in the top wall and away from the side wall along the axis of symmetry, and ending at a pointed tip configured and proportioned to be piercable by the pipetting needle, the closure being formed as a single piece of plastic material.
2. A closure according to claim 1, characterized in that it is a screw cap.
3. A closure according to claim 1 or claim 2, characterized in that the conical wall has a first part which is adjacent to the top wall and which forms a first angle with the axis of symmetry of the cylindrical side wall, and a second part which forms the tip of the conical wall and which forms a second angle with the axis of symmetry of the cylindrical side wall, said second angle being greater than the first angle.
4. A closure according to claim 3, characterized in that the first angle is between and 30° and the second angle is between 20° and
5. A closure according to claim 4, characterized in that the first angle is about 100 and the second angle is about
6. A closure according to any one of claims 1 to 5, characterized in that access to the conical wall is sealed by a metal sealing foil.
7. A closure according to any one of claims 1 to 6, characterized in that it has an .i 25 annular sealing lip adjacent the top wall, the lip being concentric with the side wall and extending inwards and lying between the side wall and the conical wall.
8. A closure device for a reagent container for use in an analysis system with an .automatic pipetting device having a pipetting needle for transferring small quantities of at least one reagent from the reagent container to a reaction cell, the closure device being characterized in that it comprises: a) a closure comprising an outer cylindrical side wall having an inner and an S..outer surface and having an axis of symmetry parallel to the side wall, an annular top wall adjacent to the side wall and having a circular ancrture, an inner conical wall with an inner and outer surface adjacent to the top wall tapering inwardly from the aperture in the top wall and away from the side wall along the axis of symmetry, and ending at a pointed tip configured and proportioned to be piercable by the pipetting needle, the closure being formed as a single piece of plastic material, and b) a plug configured and proportioned to be insertable between the cap and the container, said plug having a central orifice with an inner wall configured to abut the outer Ii rIv2OO099B:KEH 9 of 4 Q Kt s 'r surface of the conical wall in a sealing manner.
9. A closure device according to claim 8, characterized in that the closure is a screw cap.
A closure device according to claim 8 or claim 9, characterized in that the conical wall of the closure has a first part which is adjacent to the top wall and which forms a first angle with the axis of symmetry of the cylindrical side wall, an a second part which forms the tip of the conical wall and which forms a second angle with the axis of symmetry of the cylindrical side wall, said second angle being greater than the first angle.
11. A closure device, according to claim 10, characterized in that the first angle is between 5° and 300 and the second angle is between 200 and
12. A closure device according to claim 11, characterized in that the first angle is about 100 and the second angle is about
13. A closure device according to claim 8, characterized in that access to the conical wall is sealedby a metal sealing foil.
14. A closure for a reagent container for use in an analysis system substantially as hereinbefore described with reference to the accompanying drawings. SDated 17 June, 1993 F. Hoffmann-La Roche AG Patent Attorneys for the Applicant/Nominated Person SPRUSON FERGUSON IPriv2\O049B:KEH 10 of 4 CLOSURE FOR REAGENT CONTAINER ABSTRACT A closure (11) for a reagent container for use in an analysis system in which an automatic pipetting device is used for transferring small quantities of reagent from the reagent container to reaction cells. In order to simplify the process of handling the reagent container in an automatic analysis system, the closure (11) is characterized in that it is formed in one piece from a plastic and it has a cylindrical side wall (13) and an annular top wall (14) adjacent the side wall (13) and merging into a conical wall which extends inwards from the inner circle of the top wall and ends in a piercable tip (16) situated on the axis of symmetry of the cylindrical wall (13). Fig. 1 *S 8 S*0 S* LHP:1529F
AU12933/92A 1991-03-19 1992-03-16 Closure for reagent container Ceased AU640560B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH82391 1991-03-19
CH823/91 1991-03-19

Publications (2)

Publication Number Publication Date
AU1293392A AU1293392A (en) 1992-10-15
AU640560B2 true AU640560B2 (en) 1993-08-26

Family

ID=4196034

Family Applications (1)

Application Number Title Priority Date Filing Date
AU12933/92A Ceased AU640560B2 (en) 1991-03-19 1992-03-16 Closure for reagent container

Country Status (8)

Country Link
US (1) US5297599A (en)
EP (1) EP0504697B1 (en)
JP (1) JP2519370B2 (en)
AU (1) AU640560B2 (en)
CA (1) CA2062238C (en)
DE (1) DE59207914D1 (en)
ES (1) ES2097228T3 (en)
SG (1) SG46491A1 (en)

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JP2519370B2 (en) 1996-07-31
DE59207914D1 (en) 1997-03-06
US5297599A (en) 1994-03-29
EP0504697A1 (en) 1992-09-23
ES2097228T3 (en) 1997-04-01
SG46491A1 (en) 1998-02-20
AU1293392A (en) 1992-10-15
CA2062238A1 (en) 1992-09-20
CA2062238C (en) 1996-06-25
EP0504697B1 (en) 1997-01-22

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