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AU6298798A - Formulation of stabilized cationic transfection agent(s)/nucleic acid particles - Google Patents

Formulation of stabilized cationic transfection agent(s)/nucleic acid particles

Info

Publication number
AU6298798A
AU6298798A AU62987/98A AU6298798A AU6298798A AU 6298798 A AU6298798 A AU 6298798A AU 62987/98 A AU62987/98 A AU 62987/98A AU 6298798 A AU6298798 A AU 6298798A AU 6298798 A AU6298798 A AU 6298798A
Authority
AU
Australia
Prior art keywords
nucleic acid
transfection agent
formulation
acid particles
cationic transfection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU62987/98A
Other versions
AU737720B2 (en
Inventor
Joel Crouzet
Bruno Pitard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9503492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU6298798(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of AU6298798A publication Critical patent/AU6298798A/en
Application granted granted Critical
Publication of AU737720B2 publication Critical patent/AU737720B2/en
Assigned to AVENTIS PHARMA S.A. reassignment AVENTIS PHARMA S.A. Amend patent request/document other than specification (104) Assignors: RHONE-POULENC RORER S.A.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention concerns a composition containing stabilised particles of cationic transfection agent(s)/nucleic acid complexes characterised in that it includes besides said transfection agent and nucleic acid at least a non-ionic surfactant in sufficient amount for preventing the aggregation of the particles in course of time. In a preferred embodiment, the surfactant is a polyoxyalkylene or a derivative thereof.
AU62987/98A 1997-02-10 1998-02-06 Formulation of stabilized cationic transfection agent(s)/nucleic acid particles Ceased AU737720B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR97/01467 1997-02-10
FR9701467A FR2759298B1 (en) 1997-02-10 1997-02-10 FORMULATION OF CATIONIC TRANSFECTING AGENT (S) / NUCLEIC ACID PARTICLES
PCT/FR1998/000222 WO1998034648A1 (en) 1997-02-10 1998-02-06 Formulation of stabilised cationic transfection agent(s)/nucleic acid particles

Publications (2)

Publication Number Publication Date
AU6298798A true AU6298798A (en) 1998-08-26
AU737720B2 AU737720B2 (en) 2001-08-30

Family

ID=9503492

Family Applications (1)

Application Number Title Priority Date Filing Date
AU62987/98A Ceased AU737720B2 (en) 1997-02-10 1998-02-06 Formulation of stabilized cationic transfection agent(s)/nucleic acid particles

Country Status (20)

Country Link
EP (1) EP1007097B1 (en)
JP (1) JP2001511171A (en)
KR (1) KR20000070914A (en)
AT (1) ATE206932T1 (en)
AU (1) AU737720B2 (en)
BR (1) BR9807563A (en)
CA (1) CA2278665A1 (en)
CZ (1) CZ282199A3 (en)
DE (1) DE69802102T2 (en)
DK (1) DK1007097T3 (en)
ES (1) ES2166146T3 (en)
FR (1) FR2759298B1 (en)
GR (1) GR3036919T3 (en)
HU (1) HUP0001720A3 (en)
IL (1) IL130765A0 (en)
NO (1) NO993825L (en)
PT (1) PT1007097E (en)
SK (1) SK282685B6 (en)
WO (1) WO1998034648A1 (en)
ZA (1) ZA981034B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6359054B1 (en) * 1994-11-18 2002-03-19 Supratek Pharma Inc. Polynucleotide compositions for intramuscular administration
EP1070047A2 (en) * 1998-04-08 2001-01-24 Celltech Chiroscience Limited Lipids
ATE237312T1 (en) * 1998-07-20 2003-05-15 Protiva Biotherapeutics Inc NUCLEIC ACID COMPLEXES ENCAPSULATED IN LIPOSOMES
CA2401239A1 (en) * 2000-03-03 2001-09-13 Valentis, Inc. Improved poloxamer and poloxamine compositions for nucleic acid delivery
GB0009201D0 (en) * 2000-04-14 2000-05-31 Univ Nottingham Cationic polymer - Nucleic acid complexes and methods of making them
US20020091242A1 (en) 2000-10-11 2002-07-11 Michel Bessodes Acid-sensitive compounds, their preparation and uses
CN1531422A (en) * 2000-10-20 2004-09-22 Gene delivery formulations and methods for treatment of ischemic conditions
EP1232758A1 (en) * 2001-02-19 2002-08-21 Aventis Pasteur Polynucleotide formulated for improved intracellular transfer
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
SG150570A1 (en) 2004-03-03 2009-03-30 Revance Therapeutics Inc Compositions and methods for topical diagnostic and therapeutic transport
BRPI0608249A2 (en) 2005-03-03 2009-12-08 Revance Therapeutics Inc formulation, method for topical application and kit for transdermal botulinum toxin delivery
JP4653242B1 (en) 2010-02-12 2011-03-16 ナノキャリア株式会社 Particulate pharmaceutical composition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1181937A3 (en) * 1994-08-09 2004-02-04 Cytrx Corporation Novel vaccine adjuvant and vaccine
WO1996030051A1 (en) * 1995-03-31 1996-10-03 Genetic Therapy, Inc. Use of surfactants for introducing genetic material into lung cells
US6120794A (en) * 1995-09-26 2000-09-19 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells

Also Published As

Publication number Publication date
FR2759298B1 (en) 1999-04-09
WO1998034648A1 (en) 1998-08-13
FR2759298A1 (en) 1998-08-14
DK1007097T3 (en) 2002-02-11
GR3036919T3 (en) 2002-01-31
ES2166146T3 (en) 2002-04-01
DE69802102D1 (en) 2001-11-22
HUP0001720A1 (en) 2000-09-28
ZA981034B (en) 1998-08-11
KR20000070914A (en) 2000-11-25
DE69802102T2 (en) 2002-03-14
SK282685B6 (en) 2002-11-06
NO993825D0 (en) 1999-08-09
AU737720B2 (en) 2001-08-30
ATE206932T1 (en) 2001-11-15
IL130765A0 (en) 2001-01-28
NO993825L (en) 1999-08-09
CA2278665A1 (en) 1998-08-13
CZ282199A3 (en) 1999-10-13
SK108299A3 (en) 2000-05-16
HUP0001720A3 (en) 2001-10-29
BR9807563A (en) 2000-02-01
EP1007097A1 (en) 2000-06-14
PT1007097E (en) 2002-04-29
JP2001511171A (en) 2001-08-07
EP1007097B1 (en) 2001-10-17

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Legal Events

Date Code Title Description
TC Change of applicant's name (sec. 104)

Owner name: AVENTIS PHARMA S.A.

Free format text: FORMER NAME: RHONE-POULENC RORER S.A.

FGA Letters patent sealed or granted (standard patent)