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AU584122B2 - Metered dose aerosol of nifedipin - Google Patents

Metered dose aerosol of nifedipin

Info

Publication number
AU584122B2
AU584122B2 AU47732/85A AU4773285A AU584122B2 AU 584122 B2 AU584122 B2 AU 584122B2 AU 47732/85 A AU47732/85 A AU 47732/85A AU 4773285 A AU4773285 A AU 4773285A AU 584122 B2 AU584122 B2 AU 584122B2
Authority
AU
Australia
Prior art keywords
weight
glycol
polyethylene
nifedipine
nifedipin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47732/85A
Other versions
AU4773285A (en
Inventor
Kurt Burghart
Walter Burghart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuhlemann & Co
Original Assignee
Kuhlemann & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3539047&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU584122(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kuhlemann & Co filed Critical Kuhlemann & Co
Publication of AU4773285A publication Critical patent/AU4773285A/en
Application granted granted Critical
Publication of AU584122B2 publication Critical patent/AU584122B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The pharmaceutical preparation contains nifedipine as active agent and is conditioned as an aerosol by using a propelling gas or a spray. When using propelling gases, the preparation contains preferably from 2 to 5 % by weight of nifedipine, 25 to 40% by weight of polyethylene-glycol, 40 to 25% by weight of ethanol and 30 to 40% by weight, preferably 35% by weight of the propulsion agent, whereas in case of a spray, the preparation appropriately contains 19 mg of nifedipine, 70 to 100 mg of polyethylene-glycol, particularly a mixture of polyethylene-glycol 600 and polyethylene-glycol 400 in a ratio from 5:4 to 4:5, 30 to 40 mg of ethanol, 5 to 20 mg of water and optionally 2 to 5 mg of saccharine and 1 to 3 mg of flavouring agent like peppermint oil.
AU47732/85A 1984-08-23 1985-08-23 Metered dose aerosol of nifedipin Ceased AU584122B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT2708/84 1984-08-23
AT270884 1984-08-23

Publications (2)

Publication Number Publication Date
AU4773285A AU4773285A (en) 1986-03-24
AU584122B2 true AU584122B2 (en) 1989-05-18

Family

ID=3539047

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47732/85A Ceased AU584122B2 (en) 1984-08-23 1985-08-23 Metered dose aerosol of nifedipin

Country Status (9)

Country Link
EP (2) EP0175671A1 (en)
JP (1) JPH0657655B2 (en)
AT (1) ATE64093T1 (en)
AU (1) AU584122B2 (en)
DE (1) DE3583135D1 (en)
DK (1) DK184786A (en)
FI (1) FI861695A0 (en)
HU (1) HU201242B (en)
WO (1) WO1986001405A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU630399B2 (en) * 1988-12-30 1992-10-29 Kurt Burghart Pharmaceutical preparation

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3522550A1 (en) * 1985-06-24 1987-01-02 Klinge Co Chem Pharm Fab SPRAYABLE PHARMACEUTICAL PREPARATION FOR TOPICAL APPLICATION
DE3544692A1 (en) * 1985-12-18 1987-06-19 Bayer Ag DIHYDROPYRIDINE SPRAY, METHOD FOR THE PRODUCTION THEREOF AND ITS PHARMACEUTICAL USE
DE3775960D1 (en) * 1986-03-10 1992-02-27 Burghart Kurt PHARMACEUTICAL PREPARATION AND METHOD FOR THE PRODUCTION THEREOF.
DE3714402A1 (en) * 1987-04-30 1988-11-10 Kali Chemie Pharma Gmbh DRUG FORMULATION
HU199678B (en) * 1988-07-08 1990-03-28 Egyt Gyogyszervegyeszeti Gyar Process for producing aerosols containing nitroglicerol
TW247878B (en) * 1991-07-02 1995-05-21 Takeda Pharm Industry Co Ltd
IL103238A (en) 1991-09-25 1995-07-31 Fisons Plc Pressurised aerosol compositions
US6123924A (en) * 1991-09-25 2000-09-26 Fisons Plc Pressurized aerosol inhalation compositions
HU214582B (en) 1994-07-26 1998-04-28 EGIS Gyógyszergyár Rt. Spayable antihypertensive composition and process for it`s production
DE10142417A1 (en) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re drug
JP4644397B2 (en) * 2001-09-05 2011-03-02 信越化学工業株式会社 Method for producing pharmaceutical solid preparation containing poorly soluble drug
GB0215749D0 (en) * 2002-07-09 2002-08-14 3M Innovative Properties Co Medicinal suspension aerosol model systems

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784684A (en) * 1971-08-24 1974-01-08 Bayer Ag Coronary dilator in a pharmaceutical dosage unit form
AU532623B2 (en) * 1978-04-11 1983-10-06 Bayer Aktiengesellschaft Cerebral thereapeutic agent
AU546449B2 (en) * 1980-12-05 1985-09-05 Bayer Aktiengesellschaft Medicated elastic liquid plasters

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632504A (en) * 1962-05-24
JPS5446837A (en) * 1977-09-19 1979-04-13 Kanebo Ltd Easily absorbable nifedipin composition, its preparation, and anti-stenocardia containing the same
JPS5785316A (en) * 1980-11-14 1982-05-28 Kanebo Ltd Preparation of easily absorbable nifedipine preparation
JPS5846019A (en) * 1981-09-14 1983-03-17 Kanebo Ltd Nifedipine preparation with prolonged action
JPS58109412A (en) * 1981-12-23 1983-06-29 Toa Eiyou Kagaku Kogyo Kk Nifedipine solid preparation
DE3307422A1 (en) † 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen LIQUID PREPARATIONS OF DIHYDROPYRIDINES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE FIGHT AGAINST DISEASES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784684A (en) * 1971-08-24 1974-01-08 Bayer Ag Coronary dilator in a pharmaceutical dosage unit form
AU532623B2 (en) * 1978-04-11 1983-10-06 Bayer Aktiengesellschaft Cerebral thereapeutic agent
AU546449B2 (en) * 1980-12-05 1985-09-05 Bayer Aktiengesellschaft Medicated elastic liquid plasters

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU630399B2 (en) * 1988-12-30 1992-10-29 Kurt Burghart Pharmaceutical preparation

Also Published As

Publication number Publication date
FI861695A (en) 1986-04-22
EP0190292B2 (en) 1996-11-13
DK184786D0 (en) 1986-04-22
FI861695A0 (en) 1986-04-22
EP0175671A1 (en) 1986-03-26
EP0190292A1 (en) 1986-08-13
EP0190292B1 (en) 1991-06-05
DE3583135D1 (en) 1991-07-11
JPS62500031A (en) 1987-01-08
JPH0657655B2 (en) 1994-08-03
HU201242B (en) 1990-10-28
ATE64093T1 (en) 1991-06-15
HUT40757A (en) 1987-02-27
DK184786A (en) 1986-04-22
AU4773285A (en) 1986-03-24
WO1986001405A1 (en) 1986-03-13

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired