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AU582380B2 - Derivatised nucleic acid sequences - Google Patents

Derivatised nucleic acid sequences

Info

Publication number
AU582380B2
AU582380B2 AU46484/85A AU4648485A AU582380B2 AU 582380 B2 AU582380 B2 AU 582380B2 AU 46484/85 A AU46484/85 A AU 46484/85A AU 4648485 A AU4648485 A AU 4648485A AU 582380 B2 AU582380 B2 AU 582380B2
Authority
AU
Australia
Prior art keywords
nucleic acid
cytosine
acid sequences
nuclein
derivatised
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU46484/85A
Other versions
AU4648485A (en
Inventor
Hermann Graf
Helmut Lenz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU4648485A publication Critical patent/AU4648485A/en
Application granted granted Critical
Publication of AU582380B2 publication Critical patent/AU582380B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1. Derivatised nucleic acid sequence with one or more structural elements of the general formula : X-A-M in which X signifies the group see diagramm : EP0173251,P7,F2 or see diagramm : EP0173251,P7,F3 whereby the N-atom represents the amine nitrogen atom of a nuclein base and R a straight-chained or branched lower alkylene radical which can be interrupted by heteroatoms, whereby in the case of the nuclein bases, it is a question of the bases adenine, guanine, cytosine, uracil, thymine, orotic acid, xanthine, hypoxanthine, 5-hydroxymethyl-cytosine or 5-hydroxymethyluracil of the nucleic acid, A a bifunctional bridge member and M an antigen, hapten or antibody.
AU46484/85A 1984-08-28 1985-08-21 Derivatised nucleic acid sequences Expired AU582380B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843431536 DE3431536A1 (en) 1984-08-28 1984-08-28 DERIVATIZED NUCLEIC ACID SEQUENCE, METHOD FOR THE PRODUCTION THEREOF AND THE USE THEREOF FOR DETECTING NUCLEIC ACIDS
DE3431536 1984-08-28

Publications (2)

Publication Number Publication Date
AU4648485A AU4648485A (en) 1986-03-06
AU582380B2 true AU582380B2 (en) 1989-03-23

Family

ID=6244044

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46484/85A Expired AU582380B2 (en) 1984-08-28 1985-08-21 Derivatised nucleic acid sequences

Country Status (6)

Country Link
EP (1) EP0173251B1 (en)
JP (1) JPS6160697A (en)
AT (1) ATE48141T1 (en)
AU (1) AU582380B2 (en)
CA (1) CA1242657A (en)
DE (2) DE3431536A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU621572B2 (en) * 1987-10-28 1992-03-19 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0365595A4 (en) * 1987-06-26 1990-06-05 Du Pont Affinity removal of contaminating sequences from recombinant cloned na using capture beads.
JP2597698B2 (en) * 1987-10-28 1997-04-09 ハワード・フローレイ・インスティテュト・オブ・イクスペリメンタル・フィジオロジー・アンド・メディシン Oligonucleotide-polyamide conjugate
US5525465A (en) * 1987-10-28 1996-06-11 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates and methods of production and applications of the same
US5354657A (en) * 1988-01-12 1994-10-11 Boehringer Mannheim Gmbh Process for the highly specific detection of nucleic acids in solid
DE3813278A1 (en) * 1988-01-12 1989-07-20 Boehringer Mannheim Gmbh METHOD FOR DETECTING NUCLEIC ACIDS
DE3800644A1 (en) * 1988-01-12 1989-07-20 Boehringer Mannheim Gmbh PROCESS FOR HIGHLY SPECIFIC DETECTION OF NUCLEIC ACIDS IN SOLUTION
FR2627590A1 (en) * 1988-02-24 1989-08-25 Ire Celltarg Sa NUCLEIC ACID PROBE COMPRISING A CHEMICALLY MODIFIED 5 (PREMIUM) (OH) TERMINAL NUCLEOTIDE FOR NON-RADIOACTIVE MARKING AND METHODS OF PREPARATION
FR2634211B1 (en) * 1988-07-13 1992-06-26 Lebacq Philippe METHOD OF MARKING A NUCLEIC PROBE AND KIT OF REAGENTS FOR CARRYING OUT SAID METHOD
FR2644163B2 (en) * 1988-07-13 1994-09-30 Bioprobe Systems Sa METHOD OF MARKING A NUCLEIC PROBE AND KIT OF REAGENTS FOR CARRYING OUT SAID METHOD
DE3836656A1 (en) * 1988-10-27 1990-05-03 Boehringer Mannheim Gmbh NEW DIGOXIGENINE DERIVATIVES AND THEIR USE
US5356773A (en) * 1989-05-16 1994-10-18 Kinetic Investments Limited Generation of unidirectional deletion mutants
DE3916595A1 (en) * 1989-05-22 1990-11-29 Boehringer Mannheim Gmbh METHOD FOR NON-RADIOACTIVE MEASURING OF NUCLEIC ACID SYNTHESIS IN EUKARYONTIC CELLS
DE3916871A1 (en) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh MODIFIED PHOSPHORAMIDITE PROCESS FOR THE PREPARATION OF MODIFIED NUCLEIC ACIDS
EP0422861B1 (en) * 1989-10-13 2000-05-17 Zeneca Limited Probes
US5677440A (en) * 1990-07-16 1997-10-14 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
EP0752474A1 (en) 1995-07-07 1997-01-08 Boehringer Mannheim Gmbh Nucleic acid coding for CMP-N-acetyl-neuraminic acid hydroxylase and its use for the production of modified glycoproteins
AU718183B2 (en) * 1995-07-13 2000-04-06 Applied Biosystems, Llc Self-contained device integrating nucleic acid extraction, amplification and detection
US20020146728A1 (en) 1998-12-03 2002-10-10 Tanja Ligensa IGF-1 receptor interacting proteins
EP1006184A1 (en) 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
EP1099757B1 (en) 1999-11-11 2010-02-24 F. Hoffmann-La Roche Ag Process for the determination of CTp11 and for determining whether a tumor sample has metatastic potential
JP2004500852A (en) 2000-05-19 2004-01-15 エフ．　ホフマン−ラ　ロシュ　アーゲー Process for determining the tumoricidal potential of a sample by using nucleic acids that are down-regulated in human tumor cells
JP4808634B2 (en) 2004-11-19 2011-11-02 パナソニック株式会社 Moving picture coding method, moving picture decoding method, moving picture coding apparatus, moving picture decoding apparatus, program, and integrated circuit
DE602006014106D1 (en) 2005-03-14 2010-06-17 Link Genomics Inc METHOD FOR DIAGNOSIS OF PROSTATE CANCER

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1820883A (en) * 1982-06-17 1984-01-16 Imreg Inc. Sensitive tests for malignancies based on dna detection
AU2379884A (en) * 1983-01-27 1984-08-02 Enzo Biochem Inc. Methods and structures employing non-radioactive chemically labelled polynucleotide probes
AU3048384A (en) * 1983-07-14 1985-01-17 Molecular Diagnostics, Inc. Labelled nucleic acid probes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (en) * 1978-04-13 1979-11-09 Pasteur Institut METHOD OF DETECTION AND CHARACTERIZATION OF A NUCLEIC ACID OR OF A SEQUENCE OF THE SAME, AND ENZYMATIC REAGENT FOR THE IMPLEMENTATION OF THIS PROCESS
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
FR2519005B1 (en) * 1981-12-29 1985-10-25 Pasteur Institut DNA FRAGMENTS MARKED WITH AT LEAST ONE OF THEIR ENDS ENDANGERED BY MODIFIED RIBONUCLEOTIDES RECOGNIZABLE BY AFFINOUS MOLECULES AND METHOD FOR CARRYING OUT ANALYSIS OF SUCH DNA FRAGMENTS
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
EP0135587B2 (en) * 1983-02-22 2002-12-18 Syngene, Inc. Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis
US4626501A (en) * 1983-09-02 1986-12-02 Integrated Genetics, Inc. Labeled DNA
FR2558172B1 (en) * 1984-01-16 1986-06-13 Inst Nat Sante Rech Med PROBE CONTAINING MODIFIED NUCLEIC ACID AND RECOGNITION BY SPECIFIC ANTIBODIES AND USE OF SUCH PROBE AND THESE SPECIFIC ANTIBODIES TO DETECT AND CHARACTERIZE A HOMOLOGATED DNA SEQUENCE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1820883A (en) * 1982-06-17 1984-01-16 Imreg Inc. Sensitive tests for malignancies based on dna detection
AU2379884A (en) * 1983-01-27 1984-08-02 Enzo Biochem Inc. Methods and structures employing non-radioactive chemically labelled polynucleotide probes
AU3048384A (en) * 1983-07-14 1985-01-17 Molecular Diagnostics, Inc. Labelled nucleic acid probes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU621572B2 (en) * 1987-10-28 1992-03-19 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates

Also Published As

Publication number Publication date
EP0173251A3 (en) 1986-10-29
DE3431536A1 (en) 1986-03-13
AU4648485A (en) 1986-03-06
EP0173251A2 (en) 1986-03-05
DE3574383D1 (en) 1989-12-28
CA1242657A (en) 1988-10-04
EP0173251B1 (en) 1989-11-23
ATE48141T1 (en) 1989-12-15
JPH0578320B2 (en) 1993-10-28
JPS6160697A (en) 1986-03-28

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