AU5619400A - Statine-derived tetrapeptide inhibitors of beta-secretase - Google Patents
Statine-derived tetrapeptide inhibitors of beta-secretaseInfo
- Publication number
- AU5619400A AU5619400A AU56194/00A AU5619400A AU5619400A AU 5619400 A AU5619400 A AU 5619400A AU 56194/00 A AU56194/00 A AU 56194/00A AU 5619400 A AU5619400 A AU 5619400A AU 5619400 A AU5619400 A AU 5619400A
- Authority
- AU
- Australia
- Prior art keywords
- statine
- secretase
- beta
- tetrapeptide inhibitors
- derived tetrapeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13917399P | 1999-06-15 | 1999-06-15 | |
| US60139173 | 1999-06-15 | ||
| PCT/US2000/016643 WO2000077030A1 (en) | 1999-06-15 | 2000-06-15 | Statine-derived tetrapeptide inhibitors of beta-secretase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU5619400A true AU5619400A (en) | 2001-01-02 |
Family
ID=22485425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU56194/00A Abandoned AU5619400A (en) | 1999-06-15 | 2000-06-15 | Statine-derived tetrapeptide inhibitors of beta-secretase |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1192177A1 (en) |
| JP (1) | JP2003502342A (en) |
| AU (1) | AU5619400A (en) |
| CA (1) | CA2376420A1 (en) |
| WO (1) | WO2000077030A1 (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4484410B2 (en) | 1999-06-28 | 2010-06-16 | オクラホマ メディカル リサーチ ファウンデーション | Inhibitors of memapsin 2 and uses thereof |
| ATE343562T1 (en) | 2000-03-23 | 2006-11-15 | Elan Pharm Inc | COMPOUNDS AND METHODS FOR TREATING ALZHEIMER'S DISEASE |
| EP1666452A2 (en) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| PE20020276A1 (en) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | SUBSTITUTE AMINE COMPOUNDS AS ß-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER |
| EP1299352B1 (en) | 2000-06-30 | 2005-12-28 | Elan Pharmaceuticals, Inc. | Compounds to treat alzheimer's disease |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| EP1404671B1 (en) * | 2001-06-12 | 2006-04-12 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| BR0210721A (en) | 2001-06-27 | 2004-07-20 | Elan Pharm Inc | Pharmaceutically acceptable compound, salt or ester, method for making a compound, and method for treating a patient having, or preventing the patient from acquiring a disease or condition. |
| BR0211122A (en) | 2001-07-10 | 2004-10-26 | Elan Pharm Inc | Compound, methods for treating or preventing disease and for making a compound, intermediate, and use of a compound or salt |
| EP1448218A4 (en) | 2001-10-23 | 2009-01-14 | Oklahoma Med Res Found | BETA SECRETASE INHIBITORS AND METHOD OF USE |
| JP2005511735A (en) | 2001-12-06 | 2005-04-28 | イーラン ファーマスーティカルズ、インコーポレイテッド | Substituted hydroxyethylamine |
| AU2003206413A1 (en) * | 2002-01-04 | 2003-07-24 | Elan Pharmaceuticals, Inc. | Substituted amino carboxamides for the treatment of alzheimer's disease |
| AU2003229024A1 (en) | 2002-05-07 | 2003-11-11 | Elan Pharmaceuticals, Inc. | Succinoyl aminopyrazoles and related compounds |
| US7557137B2 (en) * | 2002-08-05 | 2009-07-07 | Bristol-Myers Squibb Company | Gamma-lactams as beta-secretase inhibitors |
| PE20040762A1 (en) | 2002-11-27 | 2004-11-06 | Elan Pharm Inc | SUBSTITUTED UREAS AND CARBAMATES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| WO2004076478A1 (en) * | 2003-02-28 | 2004-09-10 | Yoshiaki Kiso | PEPTIDE DERIVATIVES HAVING β-SECRETASE INHIBITORY ACTIVITY |
| US20050090449A1 (en) * | 2003-05-13 | 2005-04-28 | Boehringer Ingelheim International Gmbh | Novel statine derivatives for the treatment of Alzheimer's disease |
| AU2004258841B8 (en) | 2003-06-05 | 2010-01-07 | Elan Pharmaceuticals, Inc. | Acylated amino acid amidyl pyrazoles and related compounds |
| WO2006050861A2 (en) * | 2004-11-10 | 2006-05-18 | Boehringer Ingelheim International Gmbh | Statine derivatives for the treatment of alzheimer's disease |
| WO2006050862A1 (en) | 2004-11-10 | 2006-05-18 | Boehringer Ingelheim International Gmbh | Statine derivatives for the treatment of alzheimer's disease |
| TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
| CN101348456B (en) * | 2007-07-17 | 2011-05-11 | 中国科学院上海药物研究所 | Benzyl piperidine compound, and preparation and use thereof |
| TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
| EP2281824A1 (en) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders |
| EP2643299B1 (en) | 2010-11-22 | 2016-06-22 | Noscira, S.A. | Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions |
-
2000
- 2000-06-15 EP EP00941491A patent/EP1192177A1/en not_active Withdrawn
- 2000-06-15 JP JP2001503887A patent/JP2003502342A/en active Pending
- 2000-06-15 AU AU56194/00A patent/AU5619400A/en not_active Abandoned
- 2000-06-15 WO PCT/US2000/016643 patent/WO2000077030A1/en not_active Application Discontinuation
- 2000-06-15 CA CA002376420A patent/CA2376420A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000077030A1 (en) | 2000-12-21 |
| JP2003502342A (en) | 2003-01-21 |
| EP1192177A1 (en) | 2002-04-03 |
| CA2376420A1 (en) | 2000-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |