[go: up one dir, main page]

AU540505B2 - Di alkylamines - Google Patents

Di alkylamines

Info

Publication number
AU540505B2
AU540505B2 AU69497/81A AU6949781A AU540505B2 AU 540505 B2 AU540505 B2 AU 540505B2 AU 69497/81 A AU69497/81 A AU 69497/81A AU 6949781 A AU6949781 A AU 6949781A AU 540505 B2 AU540505 B2 AU 540505B2
Authority
AU
Australia
Prior art keywords
fluorophenacyl
formula
tertiobutylamino
fluorophenyl
ethanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU69497/81A
Other versions
AU6949781A (en
Inventor
Louis Lafon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of AU6949781A publication Critical patent/AU6949781A/en
Application granted granted Critical
Publication of AU540505B2 publication Critical patent/AU540505B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/06—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and acyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treating Waste Gases (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1. Claims (for the Contracting States : BE, CH, DE, GB, IT, LI, LU, NL, SE) A new compound belonging to the family of fluorophenacyl-amine derivatives of the formula see diagramm : EP0060954,P11,F1 [wherein A is CO or CHOH and R is CH(CH3 )2 or C(CH3 )3 ] said compound being characterized in that it is selected from the group consisting of N-(4-fluorophenacyl)-isopropylamine, N-(2-fluorophenacyl)-tertiobutylamine, 1-(2-fluorophenyl)-2-tertiobutylamino-1-ethanol, 1-(4-fluorophenyl)-2-tertiobutylamino-1-ethanol and their addition salts. 1. Claim (for the Contracting State AT) Process for the preparation of a derivative belonging to the family of fluorophenacylamine derivatives of the formula see diagramm : EP0060954,P11,F2 wherein A is CO or CHOH and R is CH(CH3 )2 or C(CH3 )3 selected from the group consisting of N-(4-fluorophenacyl)-isopropylamine, N-(2-fluorophenacyl)-tertiobutylamine, 1-(2-fluorophenyl)-2-tertiobutylamino-1-ethanol, 1-(4-fluorophenyl)-2-tertiobutylamino-1-ethanol and their addition salts, said process being characterized in that 1. a fluorophenacyl halide of formula see diagramm : EP0060954,P11,F3 wherein X1 is Cl or Br, is reacted with an amine of formula H2 NR wherein R is defined as above in an alcohol, for at least one hour at the reflux temperature of the reaction medium, to obtain a derivative of formula I wherein A is CO, and 2. the carbonyl derivative wherein A is CO thus obtained is reduced by means of NaBH4 to obtain a derivative of formula I wherein A is CHOH.
AU69497/81A 1981-03-23 1981-04-14 Di alkylamines Ceased AU540505B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP81400451A EP0060954B1 (en) 1981-03-23 1981-03-23 Derivatives of fluorophenacyl amines and their therapeutic use

Publications (2)

Publication Number Publication Date
AU6949781A AU6949781A (en) 1982-10-21
AU540505B2 true AU540505B2 (en) 1984-11-22

Family

ID=8188505

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69497/81A Ceased AU540505B2 (en) 1981-03-23 1981-04-14 Di alkylamines

Country Status (4)

Country Link
EP (1) EP0060954B1 (en)
AT (1) ATE8987T1 (en)
AU (1) AU540505B2 (en)
DE (1) DE3165495D1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2554811B2 (en) * 1979-12-14 1987-02-13 Lafon Labor (-) - 1- (2-FLUOROPHENYL) -2-TERTIOBUTYLAMINO-1-ETHANOL, THERAPEUTIC USE
FR2555576B1 (en) * 1983-11-25 1986-06-13 Lafon Labor N- (METHOXYPHENACYL) -AMINE DERIVATIVES, USE IN PARTICULAR IN THERAPEUTICS AND METHOD OF PREPARATION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759838A (en) * 1969-12-04 1971-06-03 Wellcome Found KETONES WITH BIOLOGICAL ACTIVITY

Also Published As

Publication number Publication date
EP0060954B1 (en) 1984-08-15
AU6949781A (en) 1982-10-21
EP0060954A1 (en) 1982-09-29
ATE8987T1 (en) 1984-09-15
DE3165495D1 (en) 1984-09-20

Similar Documents

Publication Publication Date Title
IE821872L (en) Amine derivatives.
RO82359B (en) Process for preparing 4-thiazolidinones
ES8507484A1 (en) PROCEDURE FOR PRODUCING BETA-LACTAMIC AND SIMILAR COMPOUNDS
IE800449L (en) Pyrazoline derivatives.
AU576886B2 (en) 1-aminophenyl-2-aminopropanone derivatives
AU540505B2 (en) Di alkylamines
RO84586B (en) Process for preparing some pyranone derivatives
AU8212582A (en) Azolyl-gamma-butyrolactone
ES8304971A1 (en) Process for the preparation of azabicyclo(3.2.0)-hept-2-ene derivatives.
GB1421554A (en) Process for the stereoselective production of intermediates in the synthesis of pgea and derivatives
GB1417322A (en) Acylamines of bicyclic hydrocarbons for the regulation of plant growth
ES448594A1 (en) Diarylbutanolamines
KR920701107A (en) Method for preparing α, β-unsaturated ketone
ES487712A1 (en) Imidazo and pyrimido-pyrido indoles, their preparation and medicines containing them.
ATE2528T1 (en) PHTHALIDISOCHINOLINE DERIVATIVES, THEIR PRODUCTION AND USE IN PHARMACEUTICALS.
IE40887L (en) Alkylsulphonylphenoxypropanolamine pharmaceuticals
GB1499193A (en) Indolino-spiropyran compounds useful as colour formers
GB1104323A (en) 3-phenylpyrrole derivatives and process for preparing the same
ES437041A1 (en) A procedure for preparing 1-ftalazone derivatives. (Machine-translation by Google Translate, not legally binding)
ES427333A1 (en) Dihalobenzyl ethers
GB1472527A (en) Additives for functional fluids
GB1490060A (en) 2-(3-substituted-4h-1,2,4-triazol-4-yl)benzo-phenones
ES479532A1 (en) Procedure for the preparation of amino acids and their silil-derivatives. (Machine-translation by Google Translate, not legally binding)
GB1336101A (en) Norbornyl compounds
ES429697A1 (en) A PROCEDURE FOR THE PREPARATION OF AN AZE-TIDINOL DERIVATIVE.