AU5242486A - Novel derivative of `` -(2-oxo 2,4,5,6,7,7a-hexahydro thieno (3,2-c) 5-pyridyl) phenyl acetic acid, process for preparing them and their therapeutic use - Google Patents

Novel derivative of `` -(2-oxo 2,4,5,6,7,7a-hexahydro thieno (3,2-c) 5-pyridyl) phenyl acetic acid, process for preparing them and their therapeutic use

Info

Publication number: AU5242486A
Authority: AU; Australia
Prior art keywords: pyridyl; oxo; preparing; acetic acid; therapeutic use
Prior art date: 1985-01-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU52424/86A

Other versions

AU581487B2 (en

Inventor

Alain Badorc

Daniel Frehel

Jean-Pierre Maffrand

Eric Vallee

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi SA

Original Assignee

Sanofi SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-31

Filing date

1986-01-16

Publication date

1986-08-07

1986-01-16 Application filed by Sanofi SA filed Critical Sanofi SA

1986-08-07 Publication of AU5242486A publication Critical patent/AU5242486A/en

1989-02-23 Application granted granted Critical

1989-02-23 Publication of AU581487B2 publication Critical patent/AU581487B2/en

2006-01-16 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)

AU52424/86A 1985-01-31 1986-01-16 Novel derivative of `` -(2-oxo 2,4,5,6,7,7a-hexahydro thieno (3,2-c) 5-pyridyl) phenyl acetic acid, process for preparing them and their therapeutic use Ceased AU581487B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8501908A FR2576901B1 (en)	1985-01-31	1985-01-31	NOVEL DERIVATIVES OF A- (OXO-2 HEXAHYDRO-2,4,5,6,7,7A THIENO (3,2-C) PYRIDYL-5) ACETIC PHENYL, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR8501908		1985-01-31

Publications (2)

Publication Number	Publication Date
AU5242486A true AU5242486A (en)	1986-08-07
AU581487B2 AU581487B2 (en)	1989-02-23

Family

ID=9316132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU52424/86A Ceased AU581487B2 (en)	1985-01-31	1986-01-16	Novel derivative of `` -(2-oxo 2,4,5,6,7,7a-hexahydro thieno (3,2-c) 5-pyridyl) phenyl acetic acid, process for preparing them and their therapeutic use

Country Status (24)

Country	Link
US (1)	US4740510A (en)
EP (1)	EP0192535A1 (en)
JP (1)	JPS61246186A (en)
AU (1)	AU581487B2 (en)
CA (1)	CA1265517A (en)
CS (1)	CS253741B2 (en)
DD (1)	DD242229A5 (en)
DK (1)	DK157553C (en)
ES (1)	ES8703881A1 (en)
FI (1)	FI860473L (en)
FR (1)	FR2576901B1 (en)
GR (1)	GR860287B (en)
HU (1)	HU193625B (en)
IL (1)	IL77598A (en)
MA (1)	MA20619A1 (en)
NO (1)	NO162965C (en)
NZ (1)	NZ214982A (en)
OA (1)	OA08196A (en)
PL (1)	PL145159B1 (en)
PT (1)	PT81946B (en)
SU (1)	SU1389679A3 (en)
TN (1)	TNSN86012A1 (en)
YU (1)	YU11986A (en)
ZA (1)	ZA86407B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2652579B1 (en) *	1989-10-02	1992-01-24	Sanofi Sa	DERIVATIVES OF 2-HYDROXY THIOPHENE AND FURANNE CONDENSED WITH A NITROGEN CYCLE, ON THE PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION.
FI101150B (en) *	1991-09-09	1998-04-30	Sankyo Co	Process for the preparation of tetrahydrothione nopyridine derivatives useful as a drug
JP3840662B2 (en) *	1994-10-07	2006-11-01	宇部興産株式会社	2-silyloxy-tetrahydrothienopyridines, salts thereof and process for producing the same
NZ334389A (en) *	1996-08-28	2001-05-25	Ube Industries	Cyclic amine derivatives
RU2203887C2 (en) *	1998-02-27	2003-05-10	Санкио Компани, Лимитед	Cyclic amino-derivatives, pharmaceutical composition and method of disease prophylaxis
HU230762B1 (en)	2000-07-06	2018-03-28	Daiichi Sankyo Company, Limited	Maleate addition salts of hydropyridine derivates
NZ526540A (en) *	2000-12-25	2004-11-26	Sankyo Co	Medicinal compositions containing aspirin and 2-acetoxy-5-(alpha-cyclopropylcarbonyl-2-flurobenzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine useful in preventing thrombus or embolus diseases
GB0125708D0 (en) *	2001-10-26	2001-12-19	Generics Uk Ltd	Novel compounds and processes
CZ302135B6 (en) *	2007-07-09	2010-11-10	Zentiva, A. S.	Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]-pyridin-2-yl acetate (prasugrel)
WO2009062044A2 (en) *	2007-11-09	2009-05-14	Dr. Reddy's Laboratories Ltd.	Processes for the preparation of prasugrel, and its salts and polymorphs
WO2009066326A2 (en) *	2007-11-19	2009-05-28	Msn Laboratories Limited	Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
CN101289454B (en) *	2008-06-10	2011-02-16	上海医药工业研究院	Method for preparing 2-oxygen-2,4,5,6,7,7alpha-hexahydro thieno [3,2-c]pyridine
DE102008046630A1 (en) *	2008-09-10	2010-03-11	Emitec Gesellschaft Für Emissionstechnologie Mbh	Modular tank system for a liquid reducing agent with a sump element
CN101402643B (en) *	2008-11-11	2012-11-28	上海现代制药股份有限公司	Industrial production method for prasugrel
CN101402593A (en) *	2008-11-11	2009-04-08	上海现代制药股份有限公司	Midbody for preparing prasugrel and method of preparing the same
CZ2008748A3 (en)	2008-11-26	2010-06-02	Zentiva, A. S	Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7- tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel)
WO2011042918A2 (en) *	2009-10-07	2011-04-14	Msn Laboratories Limited	Novel and improved processes for the preparation of prasugrel, its intermediates and pharmaceutically acceptable salts
HU229035B1 (en)	2009-12-21	2013-07-29	Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag	Process for producing prasurgel
HU229031B1 (en)	2009-12-21	2013-07-29	Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag	Process for producing prasurgel and its intermediate
CN102863457B (en) *	2010-02-02	2013-10-09	江苏威凯尔医药科技有限公司	Optically active 2-hydroxytetrahydrothienopyridine derivative, its preparation method and its use in pharmacy
CN102869668A (en)	2010-03-09	2013-01-09	斯索恩有限公司	Process for making prasugrel
CN102212069A (en) *	2010-04-06	2011-10-12	刘桂坤	Naphthene derivatives and their preparation methods and their application in cardiovascular and cerebrovascular disease drugs
CN101845052B (en) *	2010-06-11	2012-01-11	天津药物研究院	Nitrogen-containing heterocyclic ring thienopyridine ketone derivative, preparation method and application thereof
AU2011294757B2 (en) *	2010-08-26	2015-11-05	Ipca Laboratories Limited	Methods for the treatment or prophylaxis of thrombosis or embolism
CN101948479B (en) *	2010-09-29	2013-01-30	横店集团家园化工有限公司	Prasugrel intermediate and preparation method thereof
CN101985451B (en) *	2010-11-02	2012-04-25	北京赛科药业有限责任公司	Preparation method of prasugrel intermediate
CN102002056B (en) *	2010-11-02	2012-04-25	北京赛科药业有限责任公司	Preparation method of prasugrel intermediate
CN102276623A (en) *	2011-06-13	2011-12-14	安徽省虹升生物科技有限公司	Novel method of preparing prasugrel with organosilicon protectant
US20120329762A1 (en) *	2011-06-27	2012-12-27	Ashok Kumar	Anti-thrombotic compounds
CN104341433B (en) *	2013-08-02	2017-12-15	鲁南制药集团股份有限公司	A kind of preparation method of prasugrel intermediate
CN104447867B (en) *	2013-09-17	2017-12-26	江苏天士力帝益药业有限公司	A kind of thieno piperidine derivative, preparation method and applications
CN107698620A (en)	2015-06-23	2018-02-16	江苏天士力帝益药业有限公司	A kind of deuterated thieno piperidine derivative, preparation method and applications
CN108570060A (en) *	2018-05-13	2018-09-25	日照市普达医药科技有限公司	A kind of 4,5,6,7- thiophanes simultaneously therapeutic effect of [3,2-c] pyridine derivatives to thrombus
WO2020102359A1 (en)	2018-11-13	2020-05-22	Rubicon Oilfield International, Inc.	Three axis vibrating device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2495157A1 (en) *	1980-11-28	1982-06-04	Sanofi Sa	NEW PROCESS FOR PREPARING TETRAHYDRO-5, 6, 7, 7A 4H-THIENO (3, 2-C) PYRIDINONES-2
FR2495156A1 (en) *	1980-11-28	1982-06-04	Sanofi Sa	THIENO-PYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2528848A1 (en) *	1982-06-16	1983-12-23	Sanofi Sa	NEW THIENO-PYRIDONE DERIVATIVE, PREPARATION METHOD AND THERAPEUTIC APPLICATION
FR2530247B1 (en) *	1982-07-13	1986-05-16	Sanofi Sa	NOVEL THIENO (3, 2-C) PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATION
DE3302125A1 (en) *	1983-01-22	1984-07-26	Boehringer Ingelheim KG, 6507 Ingelheim	AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF

1985
- 1985-01-31 FR FR8501908A patent/FR2576901B1/en not_active Expired
- 1985-12-27 DD DD85285569A patent/DD242229A5/en unknown
- 1985-12-27 ES ES550448A patent/ES8703881A1/en not_active Expired
1986
- 1986-01-14 IL IL77598A patent/IL77598A/en unknown
- 1986-01-16 AU AU52424/86A patent/AU581487B2/en not_active Ceased
- 1986-01-20 ZA ZA86407A patent/ZA86407B/en unknown
- 1986-01-22 SU SU864010535A patent/SU1389679A3/en active
- 1986-01-27 CA CA000500411A patent/CA1265517A/en not_active Expired - Fee Related
- 1986-01-27 MA MA20844A patent/MA20619A1/en unknown
- 1986-01-29 PL PL1986257691A patent/PL145159B1/en unknown
- 1986-01-29 YU YU00119/86A patent/YU11986A/en unknown
- 1986-01-30 NZ NZ214982A patent/NZ214982A/en unknown
- 1986-01-30 CS CS86675A patent/CS253741B2/en unknown
- 1986-01-30 OA OA58777A patent/OA08196A/en unknown
- 1986-01-30 PT PT81946A patent/PT81946B/en not_active IP Right Cessation
- 1986-01-30 DK DK047186A patent/DK157553C/en not_active IP Right Cessation
- 1986-01-30 NO NO860332A patent/NO162965C/en unknown
- 1986-01-30 GR GR860287A patent/GR860287B/en unknown
- 1986-01-31 JP JP61020006A patent/JPS61246186A/en active Pending
- 1986-01-31 FI FI860473A patent/FI860473L/en not_active Application Discontinuation
- 1986-01-31 TN TNTNSN86012A patent/TNSN86012A1/en unknown
- 1986-01-31 EP EP86400215A patent/EP0192535A1/en not_active Withdrawn
- 1986-01-31 US US06/825,068 patent/US4740510A/en not_active Expired - Fee Related
- 1986-01-31 HU HU86456A patent/HU193625B/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO860332L (en)	1986-08-01
FR2576901A1 (en)	1986-08-08
EP0192535A1 (en)	1986-08-27
YU11986A (en)	1987-08-31
MA20619A1 (en)	1986-10-01
CS253741B2 (en)	1987-12-17
PT81946A (en)	1986-02-01
PL145159B1 (en)	1988-08-31
FR2576901B1 (en)	1987-03-20
HUT40440A (en)	1986-12-28
DK47186A (en)	1986-08-01
PL257691A1 (en)	1986-11-04
ZA86407B (en)	1986-09-24
DK157553C (en)	1990-06-11
NO162965C (en)	1990-03-14
HU193625B (en)	1987-11-30
NO162965B (en)	1989-12-04
IL77598A (en)	1988-12-30
ES550448A0 (en)	1987-03-01
US4740510A (en)	1988-04-26
DK157553B (en)	1990-01-22
FI860473A0 (en)	1986-01-31
AU581487B2 (en)	1989-02-23
GR860287B (en)	1986-06-02
SU1389679A3 (en)	1988-04-15
NZ214982A (en)	1988-04-29
ES8703881A1 (en)	1987-03-01
DD242229A5 (en)	1987-01-21
DK47186D0 (en)	1986-01-30
FI860473A7 (en)	1986-08-01
TNSN86012A1 (en)	1990-01-01
JPS61246186A (en)	1986-11-01
OA08196A (en)	1987-10-30
CA1265517A (en)	1990-02-06
FI860473L (en)	1986-08-01
PT81946B (en)	1987-12-30

Publication	Publication Date	Title
AU581487B2 (en)	1989-02-23	Novel derivative of `` -(2-oxo 2,4,5,6,7,7a-hexahydro thieno (3,2-c) 5-pyridyl) phenyl acetic acid, process for preparing them and their therapeutic use
HUT44493A (en)	1988-03-28	Process for production of new derivatives of cycloalcane (1,2-b) indol-sulphinamid and medical preparatives containing these compounds
CS8605412A2 (en)	1991-03-12	Method of poly-4-aminopyrrole-2-amides' derivatives production
GB2235194B (en)	1992-01-29	Stereospecific process for the preparation of furo[3,4-c] pyridine enantiomers, compounds thus obtained and therapeutical compositions thereof
CS705788A2 (en)	1989-10-13	Method of purine's new derivatives production
CS412388A2 (en)	1990-11-14	Method of 7-piperazino-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxyl acid's derivatives production
HUT45256A (en)	1988-06-28	Process for producing 1,3,4,9-tetrahydropyrano/3,4-b/indol-1-acetic acid derivatives and pharmaceutical composition containing them
PT81501B (en)	1988-03-22	Process for producing 2h-imidazo(1',2':1,2)pyrrole(3,4-b)pyri dines and of herbicidal compositions therewith
HUT38636A (en)	1986-06-30	Process for production of derivatives of imidazo /1,2-a/ kynoline and medical preparatives containing there of
HU904872D0 (en)	1991-01-28	Process for producing derivatives of pyridine-carboxylic acid
GB8811032D0 (en)	1988-06-15	New process for preparation of 3-(4'-bromobiphenyl-4-yl)tetralin-1-one
HUT47588A (en)	1989-03-28	Process for production of /+/-3-/3-piridil/-1h,3h-pirrolo /1,2-c/-tiasole-7-carbonic acid
ZA862040B (en)	1986-11-26	Novel derivatives of 5-h pyrido(3',4':4,5)pyrrolo(3,2-c)pyridine,process for their preparation and their antitumoral activity
IL64148A0 (en)	1982-01-31	New process of preparing 5,6,7,7a-tetrahydro-4h-thieno(3,2-c)pyridin-2-one derivatives
AU2757288A (en)	1989-06-29	Process for preparation of sulfone derivatives
CS8703287A1 (en)	1989-09-12	Method of 2-benzothiazolsulphenic acid's sulphenamides preparation
PT86624A (en)	1988-02-01	PROCESS FOR THE PREPARATION OF CYCLOALKANE-] 1,2-C [4,3-c: DIPYRAZOLES
CS910288A2 (en)	1990-03-14	Method of dioxazocine's derivatives production
CS810187A2 (en)	1989-07-12	Method of 2-guanidinothiazole's derivative production
CS770887A1 (en)	1989-06-13	Method of 3,3-dimethyl-2-butanone's mannich bases production
HK47392A (en)	1992-07-10	Stereospecific process for the preparation of furo[3,4-c] pyridine enantiomers, compounds thus obtained and therapeutical compositions thereof
GB8814316D0 (en)	1988-07-20	Process for preparation of polymers
CS734688A1 (en)	1990-03-14	Method of (2-acetoxymethyl-5-halogen-3-hydroxycyclopent-1-yl)acetic acid's delta-lactone production
AU581027C (en)	1996-02-01	Process for treatment of rheumatic diseases using gamma interferon
AU581027B2 (en)	1989-02-09	Process for treatment of rheumatic diseases using gamma interferon